Phytoestrogens in cancer prevention and therapy - Mechanisms of their biological activity

Anticancer Research

Volumn 25, Issue 3 C, 2005, Pages 2357-2366

  Wietrzyk, Joanna ^a   Grynkiewicz, Grzegorz ^b   Opolski, Adam ^a,c  

^a INSTITUTE OF IMMUNOLOGY AND EXPERIMENTAL THERAPY   (Poland)

^b INDUSTRIAL CHEMISTRY RESEARCH INSTITUTE   (Poland)

^c JAN DLUGOSZ UNIVERSITY   (Poland)

Author keywords

Breast cancer; Cancer prevention; Isoflavones; Phytoestrogens; Review

Indexed keywords

CYCLOPHOSPHAMIDE; DAIDZEIN; DIETHYLSTILBESTROL; ESTRADIOL; GENISTEIN; GENISTIN; IPRIFLAVONE; ISOFLAVONE DERIVATIVE; KAEMPFEROL; LIGNAN DERIVATIVE; PHYTOESTROGEN; POLYPHENOL DERIVATIVE; PROSTATE SPECIFIC ANTIGEN; PROTEIN ISOLATE; QUERCETIN; RESVERATROL; RUTOSIDE; SOYBEAN PROTEIN; TAMOXIFEN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; BONE METASTASIS; BREAST CANCER; CANCER RISK; CANCER THERAPY; CANCER TRANSPLANTATION; CELL GROWTH; CHEMICAL CARCINOGENESIS; CHEMOPROPHYLAXIS; CLINICAL TRIAL; CONCENTRATION RESPONSE; DIET SUPPLEMENTATION; DRUG EFFECT; DRUG MECHANISM; DRUG POTENTIATION; ENDOMETRIUM CARCINOMA; FOOD INTAKE; GRAIN; HORMONE ACTION; HUMAN; IN VITRO STUDY; IN VIVO STUDY; LUNG CANCER; MELANOMA; NONHUMAN; PRIORITY JOURNAL; PROSTATE CANCER; REVIEW; SOYBEAN; TUMOR GROWTH;

ANIMALS; HUMANS; NEOPLASMS; PHYTOESTROGENS;

EID: 22944482178     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (57)

1. Peeters PH, Keinan-Boker L, van der Schouw YT and Grobbee DEL: Phytoestrogens and breast cancer risk. Review of the epidemiological evidence. Breast Cancer Res Treat 77: 171-183, 2003.
2. Lee MM, Gomez SL, Chang JS, Wey M, Wang RT and Hsing AW: Soy and isoflavone consumption in relation to prostate cancer risk in China. Cancer Epidemiol Biomarkers Prev 12: 665-668, 2003.
3. Wu AH, Wan P, Hankin J, Tseng CC, Yu MC and Pike MC: Adolescent and adult soy intake and risk of breast cancer in Asian-Americans. Carcinogenesis 23: 1491-1496, 2002.
4. Jakes RW, Duffy SW, Ng FC, Gao F, Ng EH, Seow A, Lee HP and Yu MC: Mammographic parenchymal patterns and self-reported soy intake in Singapore Chinese women. Cancer Epidemiol Biomarkers Prev 11: 608-613, 2002.
5. Maskarinec G, Takata Y, Franke AA, Williams AE and Murphy SP: A 2-year soy intervention in premenopausal women does not change mammographic densities. J Nutr 134: 3089-3094, 2004.
6. Yamamoto S, Sobue T, Kobayashi M, Sasaki S and Tsugane S: Soy, isoflavones, and breast cancer risk in Japan. J Natl Cancer Inst 95: 906-913, 2003.
7. Dai Q, Franke AA, Yu H, Shu X-O, Jin F, Hebert JR, Custer L J, Gao Y-T and Zheng W: Urinary phytoestrogen excretion and breast cancer risk. Evaluating potential effect modifiers, endogenous estrogens and anthropometries. Cancer Epidemiol Biomarkers Prevent 12: 497-502, 2003.
8. Hsieh C-Y, Santell RC, Haslam SZ and Helferich WG: Estrogenic effects of genistein on the growth of estrogen receptor-positive human breast cancer (MCF-7) cells in vitro and in vivo. Anticancer Res 58: 3833-3838, 1998.
9. Dampier K, Hudson EA, Howells LM, Manson MM, Walker RA and Gescher A: Differences between human breast cell lines in susceptibility towards growth inhibition by genistein. Br J Cancer 85: 618-624, 2001.
10. Schwarz JA, Liu G and Brooks SC: Genistein-mediated attenuation of tamoxifen-induced antagonism from estrogen receptor-regulated genes. Biochem Biophys Res Commun 253: 38-43, 1998.
11. Shao Z-M, Wu J, Shen Z-Z and Barsky SH: Genistein exerts multiple suppressive effects on human breast carcinoma cells. Cancer Res 55: 4851-4857, 1998.
12. Maggiolini M, Bonofiglio D, Marsico S, Panno ML, Cenni B, Picard D and Ando S: Estrogen receptor alpha mediates the proliferative but not the cytotoxic dose-dependent effects of two major phytoestrogens on human breast cancer cells. Mol Pharmacol 60: 595-602, 2001.
13. Lu LJ, Anderson KE, Grady JJ, Kohen F and Nagamani M: Decreased ovarian hormones during a soya diet: implications for breast cancer prevention. Cancer Res 60: 4112-4121, 2000.
14. Lamartiniere CA: Protection against breast cancer with genistein: a component of soy. Am J Clin Nutr Suppl 71: 1705S-1707S, 2000.
15. Cabanes A, Wang M, Olivo S, DeAssis S, Gustafsson JA, Khan G and Hilakivi-Clarke L: Prepubertal estradiol and genistein exposures up-regulate BRCA1 mRNA and reduce mammary tumorigenesis. Carcinogenesis 25: 741-748, 2004.
16. Lamartiniere CA, Zhang J-X and Cotroneo MS: Genistein studies in rats: potential for breast cancer prevention and reproductive and developmental toxicity. Am J Clin Nutr Suppl 68: 1400S-1405S, 1998.
17. Ju YH, Doerge DR, Allred KF, Allred CD and Helferich WG: Dietary genistein negates the inhibitory effect of tamoxifen on growth of estrogen-dependent human breast cancer (MCF-7) cells implanted in athymic mice. Cancer Res 62: 2474-2477, 2002.
18. Wietrzyk J, Mazurkiewicz M, Madej J, Dzimira S, Grynkiewicz G, Radzikowski C and Opolski A: Genistein alone or combined with cyclophosphamide in the treatment of 16/C transplantable mouse mammary cancer. Med Sci Monitor 10: 414-419, 2004.
19. Silvestrini R: Cell kinetics: prognostic and therapeutic implications in human tumors: Cell Prolif 27: 579-585, 1994.
20. Wenger CR, Beardslee S, Owens MA, Pounds G, Oldaker T, Vendely P, Pandian MR, Harrington D, Clark GM and McGuire WL: DNA ploidy, S-phase and steroid receptors in more than 124,000 breast cancer patients. Breast Cancer Res Treat 28: 9-15, 1993.
21. Constantinou AI, Lantvit D, Hawthorne M, Xu X, van Breemen RB and Pezzuto JM: Chemopreventive effects of soy protein and purified soy isoflavones on DMBA-induced mammary tumors in female Sprague-Dawley rats. Nutr Cancer 47: 75-81,2001.
22. Jin Z and MacDonald RS: Soy isoflavones increase latency of spontaneous mammary tumors in mice. J Nutr 132: 3186-3190, 2002.
23. Day JK, Bésch-Williford C, McMann TR, Hufford MG, Lubahn D and MacDonald RS: Dietary genistein increased DMBA-induced mammary adenocarcinoma in wild-type, but not ER alpha KO, mice. Nutr Cancer 39: 226-232, 2001.
24. Kim H, Hall P, Smith M, Kirk M, Prasain JK, Barnes S and Grubbs C: Chemoprevention by grape seed extract and genistein in carcinogen-induced mammary cancer in rats is diet dependent. J Nutr 134: 3445S-3452S, 2004.
25. Allred CD, Ju YH, Allred KF, Chang J and Helferich WG: Dietary genistin stimulates growth of estrogen-dependent breast cancer tumors similar to that observed with genistein. Carcinogenesis 22: 1667-1673, 2001.
26. Brownson DM, Azios NG, Fuqua BK, Dharmawardhane SF and Mabry TJ: Flavonoid effects relevant to cancer. J Nutr 132(11 Suppl): 3482S-3489S, 2002.
27. Sarkar FH and Li Y: Mechanisms of cancer chemoprevention by soy isoflavone genistein. Cancer Metastasis Rev 21: 265-280, 2002.
28. Gong L, Li Y, Nedeljkovic-Kurepa A and Sarkar FH: Inactivation of NF-kappaB by genistein is mediated via Akt signaling pathway in breast cancer cells. Oncogene 22: 4702-4709, 2003.
29. Frey RS and Singletary KW: Genistein activates p38 mitogen-activated protein kinase, inactivates ERK1/ERK2 and decreases Cdc25C expression in immortalized human mammary epithelial cells. J Nutr 133: 226-231, 2003.
30. Belenky M, Prasain J, Kim H and Barnes S: DING, a genistein target in human breast cancer: a protein without a gene. J Nutr 133: 2497S-2501S, 2003.
31. Li Y, Bhuiyan M and Sarkar FH: Induction of apoptosis and inhibition of c-erbB-2 in MDA-MB-435 cells by genistein. Int J Oncol 15: 525-533, 1999.
32. Day JK, Bauer AM, DesBordes C, Zhuang Y, Kim BE, Newton LG, Nehra V, Forsee KM, MacDonald RS, Besch-Williford C, Huang TH and Lubahn DB: Genistein alters methylation patterns in mice. J Nutr 132(Suppl 8): 2419S-2423S, 2002.
33. Iwasaki T, Mukai M, Tsujimura T, Tatsuta M, Nakamura H, Terada N and Akedo H: Ipriflavone inhibits osteolytic bone metastasis of human breast cancer cells in a nude mouse model. Int J Cancer 100: 381-387, 2002.
34. Kurzer MS: Phytoestrogen supplement use by women. J Nutr 133: 1983S-1986S, 2003.
35. Lian, F, Li Y, Bhuiyan M and Sarkar FH: p53-independent apoptosis induced by genistein in lung cancer cells. Nutr Cancer 33: 125-131, 1999.
36. Knekt P, Kumpulainen J, Jarvinen R, Rissanen H, Heliovaara M, Reunanen A, Hakulinen T and Aromaa A: Flavonoid intake and risk of chronic diseases. Am J Clin Nutr 76: 560-568, 2002.
37. Wietrzyk J, Boratynski J, Grynkiewicz G, Ryczynski A, Radzikowski C and Opolski A: Antiangiogenic and antitumour effects in vivo of genistein applied alone or combined with cyclophosphamide. Anticancer Res 21: 3893-3896, 2001.
38. Wietrzyk J, Opolski A, Madej J and Radzikowski C: Antitumour and antimetastatic effect of genistein alone or combined with cyclophosphamide in mice transplanted with various tumours depends on the route of tumour transplantation. In Vivo 14: 357-362, 2000.
39. Wietrzyk J, Opolski A, Madej J and Radzikowski C: The antitumor effect of postoperative treatment with genistein alone or combined with cyclophosphamide in mice bearing transplan table tumors. Acta Pol Pharm 57(Suppl): 5-8, 2000.
40. Seike N, Wanibuchi H, Morimura K, Wei M, Nishikawa T, Hirata K, Yoshikawa J and Fukushima S: Enhancement of lung carcinogenesis by nonylphenol and genistein in a F344 rat multiorgan carcinogenesis model. Cancer Lett 192: 25-36, 2003.
41. Asensi M, Medina I, Ortega A, Carretero J, Bano MC, Obrador E and Estrela JM: Inhibition of cancer growth by resveratrol is related to its low bioavailability. Free Radic Biol Med 33: 387-398, 2002.
42. Li D, Yee JA, McGuire MH, Murphy PA and Yan L: Soybean isoflavones reduce experimental metastasis in mice. J Nutr 129: 1075-1078, 1999.
43. Horn-Ross PL, John EM, Canchola AJ, Stewart SL and Lee MM: Phytoestrogen intake and endometrial cancer risk. J Natl Cancer Inst 95: 1158-1164, 2003.
44. Newbold RR, Banks EP, Bullock B and Jefferson WN: Uterine adenocarcinoma in mice treated neonatally with genistein. Cancer Res 61: 4325-4328, 2001.
45. Takimoto CH, Glover K, Huang X, Hayes SA, Gallot L, Quinn M, Jovanovic BD, Shapiro A, Hernandez L, Goetz A, Llorens V, Lieberman R, Crowell JA, Poisson BA and Bergan RC: Phase I pharmacokinetic and pharmacodynamic analysis of unconjugated soy isoflavones administered to individuals with cancer. Cancer Epidemiol Biomarkers Prevent 12: 1213-1221, 2003.
46. Spentzos D, Mantzoros C, Regan MM, Morrissey ME, Duggan S, Flickner-Garvey S, McCormick H, DeWolf W, Balk S and Bubley GJ: Minimal effect of a low-fat/high soy diet for asymptomatic, hormonally naive prostate cancer patients. Clin Cancer Res 9: 3282-3287, 2003.
47. Li Y and Sarkar FH: Inhibition of nuclear factor kappaB activation in PC3 cells by genistein is mediated via Akt signaling pathway. Clin Cancer Res 8: 2369-2377, 2002.
48. Li Y and Sarkar FH: Down-regulation of invasion and angiogenesis-related genes identified by cDNA microarray analysis of PC3 prostate cancer cells treated with genistein. Cancer Lett 186: 157-164, 2002.
49. Li Y and Sarkar FH: Gene expression profiles of genistein-treated PC3 prostate cancer cells J. Nutr 132: 3623-3631, 2002.
50. Wang S, DeGroff VL and Clinton SK: Tomato and soy polyphenols reduce insulin-like growth factor-I-stimulated rat prostate cancer cell proliferation and apoptotic resistance in vitro via inhibition of intracellular signaling pathways involving tyrosine kinase. J Nutr 133: 2367-2376, 2003.
51. Zhou JR, Yu L, Zhong Y and Blackburn GL: Soy phytochemicals and tea bioactive components synergistically inhibit androgen-sensitive human prostate tumors in mice. J Nutr 133: 516-521, 2003.
52. Zhu Q, Meisinger J, Van Thiel DH, Zhang Y and Mobarhan S: Effects of soybean extract on morphology and survival of Caco-2, SW620, and HT-29 cells. Nutr Cancer 42: 131-140, 2002.
53. Gentile MS, Vasu C, Green A, Murillo G, Das Gupta TK, Constantinou AI, Prabhakar BS and Salti GI: Targeting colon cancer cells with genistein-17.1A immunoconjugate. Int J Oncol 22: 955-959, 2003.
54. Chen X and Anderson JJ: Isoflavones inhibit proliferation of ovarian cancer cells in vitro via an estrogen receptor-dependent pathway. Nutr Cancer 41: 165-171, 2001.
55. Nagata C, Takatsuka N, Kawakami N and Shimizu H: A prospective cohort study of soy product intake and stomach cancer death. Br J Cancer 87: 31-36, 2002.
56. Lyn-Cook BD, Stottman HL, Yan Y, Blann E, Kadlubar FF and Hammons GJ: The effects of phytoestrogens on human pancreatic tumor cells in vitro. Cancer Lett 142: 111-119, 1999.
57. Horn-Ross PL, Hoggatt KJ and Lee MM: Phytoestrogens and thyroid cancer risk. The San Francisco Bay area thyroid cancer study. Cancer Epidemiol Biomarkers Prev 11: 43-49, 2002.