Range and sensitivity as descriptors of molecular property spaces in dynamic QSAR analyses

Journal of Medicinal Chemistry

Volumn 48, Issue 15, 2005, Pages 4947-4952

  Vistoli, Giulio ^a   Pedretti, Alessandro ^a   Villa, Luigi ^a   Testa, Bernard ^b  

^a UNIVERSITY OF MILAN   (Italy)

^b LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

1 (2 METHOXYPHENYL) 4 (4 PHTHALIMIDOBUTYL)PIPERAZINE; 1,4 DIHYDRO 2,6 DIMETHYL 4 (4 NITROPHENYL) 3,5 PYRIDINEDICARBOXYLIC ACID 3 AMIDE 5 [3 (4,4 DIPHENYL 1 PIPERIDINYL)PROPYL]AMIDE; 1,4 DIHYDRO 2,6 DIMETHYL 4 (4 NITROPHENYL) 3,5 PYRIDINEDICARBOXYLIC ACID [3 (4,4 DIPHENYL 1 PIPERIDINYL)PROPYL]AMIDE METHYL ESTER; 2 (2 AMINOETHOXYMETHYL) 6 ETHYL 1,4 DIHYDRO 4 (4 NITROPHENYL) 3,5 PYRIDINEDICARBOXYLIC ACID 5 AMIDE 3 [3 (4,4 DIPHENYL 1 PIPERIDINYL)PROPYL]AMIDE; 2 [[2 (2,6 DIMETHOXYPHENOXY)ETHYL]AMINOMETHYL] 1,4 BENZODIOXAN; 3 [2 (2,3,3A,4,5,9B HEXAHYDRO 6 METHOXY 1H BENZ[E]ISOINDOL 2 YL)ETHYL]PYRIDO[3',4':4,5]THIENO[3,2 D]PYRIMIDINE 2,4(1H,3H) DIONE; 3 [3 [4 [4 FLUORO 2 (2,2,2 TRIFLUOROETHOXY)PHENYL] 1 PIPERAZINYL]PROPYL] 5 METHYL 1H PYRIMIDINE 2,4 DIONE; 5 CHLORO N [2 (2 CYCLOPROPYLMETHOXYPHENOXY)ETHYL] ALPHA,ALPHA DIMETHYL 1H INDOLE 3 ETHANAMINE; 5 METHYLURAPIDIL; 7 CHLORO 3,4,5,6 TETRAHYDRO 4 METHYL 2 VINYLTHIENO[4,3,2 EF][3]BENZAZEPINE; 8 [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] 8 AZASPIRO[4.5]DECANE 7,9 DIONE; 8 [3 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]PROPYLCARBAMOYL] 3 METHYLFLAVONE; ABANOQUIL; AH 11110A; ALFUZOSIN; ALPHA 1 ADRENERGIC RECEPTOR; ALPHA 1A ADRENERGIC RECEPTOR; ALPHA 1B ADRENERGIC RECEPTOR; BENZOXATHIAN; BUNAZOSIN; CORYNANTHINE; CYCLAZOCINE; DISCRETAMINE; DOXAZOSIN; GG 818; INDORAMIN; JHT 601; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; NIGULDIPINE; PHENTOLAMINE; PRAZOSIN; REC 15 2615; SILODOSIN; SL 89 0591; SNAP 1069; SNAP 8719; SPIPERONE; TAMSULOSIN; TERAZOSIN; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; CONFORMATION; CORRELATION ANALYSIS; DIPOLE; LIGAND BINDING; LIPOPHILICITY; MATHEMATICAL COMPUTING; MOLECULAR MODEL; MONTE CARLO METHOD; PHYSICAL CHEMISTRY; PROTEIN FOLDING; QUANTITATIVE STRUCTURE ACTIVITY RELATION; SENSITIVITY ANALYSIS; STRUCTURE ANALYSIS; SURFACE PROPERTY; THREE DIMENSIONAL IMAGING;

CHEMISTRY, PHYSICAL; LIGANDS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MONTE CARLO METHOD; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RECEPTORS, ADRENERGIC, ALPHA-1; SOLVENTS;

EID: 22744455997     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0408969     Document Type: Article

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