Synthesis, pharmacological evaluation, and structure-activity relationship and quantitative structure-activity relationship studies on novel derivatives of 2,4-diamino-6,7-dimethoxyquinazoline α1-adrenoceptor antagonists

Journal of Medicinal Chemistry

Volumn 42, Issue 3, 1999, Pages 427-437

  Leonardi, Amedeo ^a   Motta, Gianni ^a   Boi, Carlo ^a   Testa, Rodolfo ^a   Poggesi, Elena ^a   De Benedetti, Pier G ^b   Menziani, M Cristina ^b  

^a Recordati SpA   (Italy)

^b UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

1 (4 AMINO 6,7 DIMETHOXY 2 QUINAZOLINYL) 4 (BENZOYLACETYL)PIPERAZINE; 1 (4 AMINO 6,7 DIMETHOXY 2 QUINAZOLINYL) 4 [(2 ISOPROPYL 6 METHOXYPHENOXY)ACETYL]PIPERAZINE HYDROCHLORIDE; 4 AMINO 6,7 DIMETHOXY 2 (4,4 DIPHENYL 1 PIPERIDINYL)QUINAZOLINE; ALPHA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; PIPERAZINE DERIVATIVE; QUINAZOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ALPHA ADRENERGIC RECEPTOR BLOCKING; ANIMAL EXPERIMENT; ARTICLE; DOG; DRUG ACTIVITY; DRUG EFFECT; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; NONHUMAN; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RECEPTOR AFFINITY;

ADRENERGIC ALPHA-ANTAGONISTS; ANIMALS; DOGS; MAGNETIC RESONANCE SPECTROSCOPY; PIPERAZINES; QUINAZOLINES; RATS; RECEPTORS, ADRENERGIC, ALPHA-1; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0033011257     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9805337     Document Type: Article

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