Identification of gene sequences overexpressed in senescent and Werner syndrome human fibroblasts

Experimental Gerontology

Volumn 31, Issue 1-2, 1996, Pages 159-174

  Lecka Czernik, Beata ^a   Moerman, Elena J ^a   Jones, Richard A ^a   Goldstein, Samuel ^a  

^a CENTRAL ARKANSAS VETERANS HEALTHCARE SYSTEM   (United States)

Author keywords

'zinc finger' protein; acid sphingomyelinase; LIM protein; nm23 H2; senescence; subtracted cDNA library; Werner syndrome; 2 chimerin

Indexed keywords

BIOTIN; COMPLEMENTARY DNA; DNA; ELONGATION FACTOR; FIBRONECTIN; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE TRIPHOSPHATE; INITIATION FACTOR; NUCLEIC ACID; OSTEONECTIN; RNA; SPHINGOMYELIN PHOSPHODIESTERASE; TRANSFER RNA; ZINC FINGER PROTEIN;

ARTICLE; CONTROLLED STUDY; DNA SYNTHESIS; FEMALE; FIBROBLAST; GENE; GENE EXPRESSION; GENE SEQUENCE; HUMAN; HUMAN CELL; MALE; NEWBORN; PHENOTYPE; PRIORITY JOURNAL; SENESCENCE; WERNER SYNDROME;

EID: 0029922445     PISSN: 05315565     EISSN: None     Source Type: Journal    
DOI: 10.1016/0531-5565(95)02014-4     Document Type: Article

References (86)

1. ARGAVES, W.S., TRAN, H., BURGESS, W.H., and DICKERSON, K. Fibulin is an extracellular matrix and plasma glycoprotein with repeated domain structure. J. Cell Biol. 111, 3155-3164, 1990.
2. BEVILACQUA, G., SOBEL, M.E., LIOTTA, L.A., and STEEG, P.S. Association of low nm23 RNA levels in human primary infiltrating ductal breast carcinomas with lymph node involvement and other histopathological indicators of high metastatic potential. Cancer Res. 49, 5185-5190, 1989.
3. CALL, K.M., GLASER, T., ITO, C.Y., BUCKLER, A.J., PELLETIER, J., HABER, D.A., ROSE, E.A., KRAL, A., YEGER, H., LEWIS, W.H., JONES, C., and HOUSMAN, D.E. Isolation and characterization of a zinc finger polypeptide gene at the human chromosome 11 Wilms' tumor locus. Cell 60, 509-520, 1990.
4. CHOMCZYNSKI, P. and SACCHI, N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenolchloroform extraction. Anal. Biochem. 162, 156-159, 1987.
5. CHURCH, G.M. and GILBERT, W. Genomic sequencing. Proc. Natl. Acad. Sci. USA 81, 1991-1995, 1984.
6. CRISTOFALO, V.J. and PIGNOLO, R.J. Replicative senescence of human fibroblast-like cells in culture. Physiol. Rev. 73, 617-638, 1993.
7. DICE, F.J. Cellular and molecular mechanisms of aging. Physiol. Rev. 73, 149-159, 1993.
8. DJE, K.J., MAZABRAUD, A., VIEL, A., le MAIRE, M., DENIS, H., CRAWFORD, E., and BROWN D.D. Three genes under different developmental control encode elongation factor 1-α in Xenopus laevis. Nucleic Acid Res. 18, 3489-3493, 1990.
9. DUGUID, J.R., ROHWER, R.G., and SEED, B. Isolation of cDNAs of scrapie-modulated RNAs by subtractive hybridization of a cDNA library. Proc. Natl Acad. Sci. USA 85, 5738-5742, 1988.
10. EPSTEIN, C.J., MARTIN, G.M., SCHULTZ, A.L., and MOTULSKI, A.G. Werner syndrome: A review of its symptomatology, natural history, pathologic features, genetics and relationship to the natural aging process. Medicine 45, 177-221, 1966.
11. 2+-binding glycoprotein SPARC modulates cell cycle progression in bovine aortic endothelial cells. Proc. Natl. Acad. Sci. USA 88, 2648-2652, 1991.
12. GILLES, A.-M., PRESECAN, E., VONICA, A., and LASCU, I. Nucleoside diphosphate kinase from human erythrocytes. J. Biol. Chem. 266, 8784-8789, 1991.
13. GOLDSTEIN, S. Human genetic disorders which feature accelerated aging. In: The Genetics of Aging, Schneider, E.L., ed., pp. 171-224, Plenum Press, New York, 1978.
14. GOLDSTEIN, S., MURANO, S., BENES, H., MOERMAN, E.J., JONES, R.A., THWEATT, R., SHMOOKLER REIS, R.J., and HOWARD, B.H., Studies on the molecular genetic basis of replicative senescence in Werner syndrome and normal fibrobtasts. Exp. Gerontol. 24, 461-468, 1989.
15. GOLDSTEIN, S. Replicative senescence: The human fibroblast comes of age. Science 249, 1129-1133, 1990.
16. GOLDSTEIN, S. The biology of aging. In: Textbook of Internal Medicine, Kelley, W.N. (Editor), 2nd ed., pp. 2336-2342, J.B. Lippincott, Philadelphia, 1992.
17. GOLDSTEIN, S., MOERMAN, E.J., and BAXTER, R.C. Accumulation of insulin-like growth factor binding protein-3 in conditioned medium of human fibroblasts increases with chronological age of donor and senescence in vitro. J. Cell Physiol. 156, 294-302, 1993.
18. GOTO, M., RUBENSTEIN, M., WEBER, J., WOODS, K., and DRAYNA, D. Genetic linkage of Werner's syndrome to five markers on chromosome 8. Nature 355, 735-738, 1992.
19. GRIGORIEV, V.G., MOERMAN, E.J., and GOLDSTEIN S. Overexpression of insulin-like growth factor binding protein-3 by senescent human fibroblasts: Attenuation of the mitogenic response to IGF-I. Exp. Cell Biol. 219, 315-321, 1995.
20. rac derived by alternative splicing of the human n-chimerin gene, is selectively expressed in brain regions and testes. Mol. Cell. Biol. 13, 4986-4998, 1993.
21. HARLEY, C.B. and GOLDSTEIN, S. Cultured human fibroblasts: Distribution of cell generations and a critical limit. J. Cell. Physiol. 97, 509-516, 1978.
22. HAYFLICK, L. The limited in vitro lifetime of human diploid cell strains. Exp. Cell Res. 37, 614-636, 1965.
23. JARVIS, W.D., KOLESNICK, R.N., FORNARI, F.A., TRAYLOR, R.S., GERWITZ, D.A., and GRANT, S. Induction of apoptotic DNA damage and cell death by activation of the sphingomyelin pathway. Proc. Natl. Acad. Sci. USA 91, 73-77, 1994.
24. JELINEK, W.R. and SCHMID, C.W. Repetitive sequences in eukaryotic DNA and their expression. Annu. Rev. Biochem. 51, 813-844, 1982.
25. JOSEPH, L.J., LE BEAU, M.M., JAMIESON JR, G.A., ACHARYA, S., SHOWS, T.B., ROWLEY, J.D., and SUKHATME, V.P. Molecular cloning, sequencing, and mapping of EGR2, a human early growth response gene encoding a protein with "zinc-binding finger" structure. Proc. Natl. Acad. Sci. USA 85, 7164-7168, 1988.
26. KADONAGA, J.T., CARNER, K.R., MASIARZ, F.R., and TIJAN, R. Isolation of cDNA encoding transcription factor Sp1 and functional analysis of the DNA binding domain. Cell 51, 1079-1090, 1987.
27. KANZAKI, T., OLOFSSON, A., MOREN, A., WERNSTEDT, C., HELLMAN, U., MIYAZONO, K. CLAESSON-WELSH, L., and HELDIN, C. TGF-β1 binding protein: A component of the large latent complex of TGF-β1 with multiple repeat sequences. Cell 61, 1051-1061, 1990.
28. KAZIRO, Y. Replication sequences in eukaryotic DNA and their expression. Biochim. Biophys. Acta 505, 95-127, 1978.
29. KENYON, K., CONTENTE, S., TRACKMAN, P.C., TANG, J., KAGAN, H.M., and FRIEDMAN, R.M. Lysyl oxidase and rrg messenger RNA. Science 253, 802, 1991.
30. KENYON, K., MODI, W.S., CONTENTE, S., and FRIEDMAN, R.M. A novel human cDNA with a predicted protein similar to lysyl oxidase maps to chromosome 15q24-q25. J. Biol. Chem. 268, 18435-18437, 1993.
31. KLUG, A. and RHODES, D. Zinc fingers: A novel protein fold for nucleic acid recognition. Cold Spring Harb. Symp. Quantitat. Biol. 52, 473-482, 1987.
32. KOLESNICK, R. and GOLDE, D.W. The sphingomyelin pathway in tumor necrosis factor and interleukin-1 signaling. Cell 77, 325-328, 1994.
33. KORNBLIHTT, A.R., VIBE-PEDERSEN, K., and BARALLE, F.E. Isolation and characterization of cDNA clones for human and bovine fibronectins. Proc. Natl. Acad. Sci. USA 80, 3218-3222, 1983.
34. KOTHS, K., TAYLOR, E., HALENBECK, R., CASIPIT, C., and WANG, A. Cloning and characterization of a human Mac-2-binding protein, a new member of the superfamily defined by the macrophage scavenger receptor cysteine-rich domain. J. Biol. Chem. 268, 14245-14249, 1993.
35. KOZAK, M. An analysis of vertebrate mRNA sequences: Intimations of translational control. J. Cell Biol. 115, 887-903, 1991.
36. KRIEG, P.A. and MELTON, D.A. Functional messenger RNAs are produced by SP6 in vitro transcription of cloned cDNAs. Nucleic Acid Res. 12, 7057-7070, 1984.
37. LECKA-CZERNIK, B., LUMPKIN, C.K., and GOLDSTEIN, S. An overexpressed gene transcript in senescent and quiescent human fibroblasts encoding a novel protein in the EGF-like repeat family stimulates DNA synthesis. Mol. Cell. Biol. 15, 120-128, 1995.
38. LEE, S., WOLFRAIM, L.A., and WANG, E. Differential expression of S1 and elongation factor-1 alpha during rat development. J. Biol. Chem. 268, 24453-24459, 1993.
39. LIOTTA, L.A. and STEEG, P.S. Clues to the function of Nm23 and Awd proteins in development, signal transduction and tumor metastasis provided by studies of Dictyostelium discoideum. J. Natl. Cancer Instit. 82, 1170-1173, 1990.
40. LIU, S., THWEATT, R., LUMPKIN, C.K., and GOLDSTEIN, S. Suppression of calcium-dependent membrane currents in human fibroblasts by senescence and forced expression of a novel gene sequence. Proc. Natl. Acad. Sci. USA 91, 2186-2190, 1994.
41. MANIATIS, T., SAMBROOK, J., and FRITSCH, E.F. Molecular Cloning: A Laboratory Manual, 2nd ed. Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, 1989.
42. MANN, K., DEUTZMAN, R., AUMAILLEY, M., TIMPL, R., RAIMONDI, L., YAMADA, Y., PAN, T., CONWAY, D., and CHU, M. Amino acid sequence of mouse nidogen, a multidomain basement membrane protein with binding activity for laminin, collagen IV and cells. EMBO J. 8, 65-72, 1989.
43. MASLEN, C.L., CORSON, G.M., MADDOX, B.K., GLANVILLE, R.W., and SAKAI, L.Y. Partial sequence of a candidate gene for the Marfan syndrome. Nature 352, 334-337, 1991.
44. MOERMAN, E.J., THWEATT, R., MOERMAN, A.M., JONES, R.A., and GOLDSTEIN, S. Insulin-like growth factor binding protein-3 is overexpressed in senescent and quiescent human fibroblasts. Exp. Gerontol. 28, 361-370, 1993.
45. MOLDAVE, K. Eukaryotic protein synthesis. Annu. Rev. Biochem. 54, 1109-1149, 1985.
46. MORRIS, J.F., HROMAS, R., and RAUSCHER, F.J., III. Characterization of the DNA-binding properties of the myeloid zinc finger protein MZF1: Two independent DNA-binding domains recognize two DNA consensus sequences with a common G-rich core. Mol. Cell Biol. 14, 1786-1795, 1994.
47. MURANO, S., THWEATT, R., SHMOOKLER REIS, R.J., JONES, R.A., MOERMAN, E.J., and GOLDSTEIN, S. Diverse gene sequences are overexpressed in Werner syndrome fibroblasts undergoing premature replicative senescence. Mol. Cell. Biol. 11, 3905-3914, 1991.
48. NORWOOD, T.H., PENDERGRASS, W.R., SPRAQUE, C.A., and MARTIN, G.M. Dominance of the senescent phenotype in heterokaryons between replicative and postreplicative human fibroblast-like cells. Proc. Natl. Acad. Sci. USA 71, 2231-2235, 1974.
49. NORWOOD, T.H., SMITH, J.R., and STEIN, G.H. Aging at the cellular level: The human fibroblastlike cell model. In: Handbook of Biology of Aging, 3rd ed., Schneider, E.L. and Rowe, J.W. (Editors), pp. 131-154, Academic Press, San Diego, Calif., 1990.
50. OBEID, L.M. Ceramide: An endogenous inducer of cellular senescence. Clin. Res. 42, 1994.
51. OBEID, L.M., LINARDIC, C.M., KAROLAK, L.A., and HANNUM, Y.A. Programmed cell death induced by ceramide. Science 259, 1769-1771, 1993.
52. OKAYAMA, H., KAWAICHI, M., BROWNSTEIN, M., LEE, F., YOKOTA, T., and ARAI, K. High-efficiency cloning of full-length cDNA; Construction and screening of cDNA expression libraries for mammalian cells. Methods Enzymol. 154, 3-28, 1987.
53. PANAYOTOU, G., END, E., AUMAILLEY, M., TIMPL, R., and ENGEL, J. Domains of laminin with growth-factor activity. Cell 56, 93-101, 1989.
54. PATHAK, V.K., NIELSEN, P.J., TRACHSEL, H., and HERSHEY, J.W. Structure of the subunit of translation initiation factor eIF-2. Cell 54, 633-639, 1988.
55. PONTE, P., NG, S.Y., ENGEL, J., GUNNING, P., and KEDES, L. Evolutionary conservation in the untranslated regions of actin mRNAs: DNA sequence of human beta-actin cDNA. Nucleic Acids Res. 12, 1687-1696, 1984.
56. RIDLEY, A.J., PATERSON, H.F., JOHNSON, C.L., DIEKMANN, D., and HALL, A. The small GTP-binding protein rac regulates growth factor induced membrane ruffling. Cell 70, 401-411, 1992.
57. ROONEY, B.C., HORNE, C.H., and HARDMAN, N. Molecular cloning of a cDNA for human pregnancy-specific β-1-glycoprotein: Homology with human carcinoembryonic antigen and related proteins. Gene 71, 439-449, 1988.
58. RUOSLAHTI, E. and YAMAGUCHI, Y. Proteoglycans as modulators of growth factor activities. Cell 64, 867-869, 1991.
59. SADLER, I., CRAWFORD, A.W., MICHELSEN, J.W., and BECKERLE, M.C. Zyxin and cCRP: Two interactive LIM domain proteins associated with the cytoskeleton. J. Cell Biol. 119, 1573-1587, 1992.
60. SAKAMOTO, K., FORDIS, C.M., CORSICO, C.D., HOWARD, T.H., and HOWARD, B.H. Modulation of HeLa cell growth by transfected 7SL RNA and Alu gene sequences. J. Biol. Chem. 266, 3031-3038, 1991.
61. SALK, D. Werner's syndrome: A review of recent research with an analysis of connective tissue metabolism, growth control of cultured cells and chromosomal aberrations. Hum. Genet. 62, 1-5, 1982.
62. SANGER, F., NICKEL, S., and COULSON, A.R. DNA sequencing with chain terminating inhibitors. Proc. Natl. Acad. Sci. USA 74, 5463-5467, 1977.
63. SCHELLENBERG, G.D., MARTIN, G.M., WIJSMAN, E.M., NAKURA, J., MIKI, T., and OGIHARA, T. Homozygosity mapping and Werner's syndrome. Lancet 339, 1002, 1992.
64. SCHMEICHEL, K.L. and BECKERLE, M.C. The LIM domain is a modular protein-binding interface. Cell 79, 211-219, 1994.
65. SCHUCHMAN, E.H., SUCCHI, M., TAKAHASHI, T., SANDHOFF, K., and DESNICK, R.J. Human acid sphingomyelinase. Isolation, nucleotide sequence and expression of the full-length and alternatively spliced cDNAs. J. Biol. Chem. 266, 8531-8539, 1991.
66. SCHWEINFEST, C.W., HENDERSON, K.W., GU, J., KOTTARDIS, S.D., BESBEAS, S., PANOTOPOULOU, E., and PAPAS, T.S. Subtraction hybridization cDNA libraries from colon carcinoma and hepatic cancer. Genet. Anal. Tech. Appl. 7, 64-70, 1990.
67. SHIINA, N., GOTOH, Y., KUBOMURA, N., IWAMATSU, A., and NISHIDA, E. Microtubule severing by elongation factor 1α. Science 266, 282-285, 1994.
68. SHOW, G. and KAMEN, R. A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation. Cell 46, 659-667, 1986.
69. SHUTZE, S., POTTHOFF, K., MACHLEIDT, T., BERKOVIC, D., WIEGMANN, K., and KRONKE, M. TNF activates NF-κB by phophatidylcholine-specific phospholipase C-induced "acidic" sphingomyelin breakdown. Cell 71, 765-776, 1992.
70. SIVE, H.L. and ST. JOHN, T. A simple subtractive hybridization technique employing photoactivatable biotin and phenol extraction. Nucleic Acid Res. 16, 10937, 1988.
71. STAHL, J.A., LEONE, A., ROSENGARD, A.M., PORTER, L., KING, C.R., and STEEG, P.S. Identification of a second human nm23 gene, nm23-H2. Cancer Res. 51, 445-449, 1991.
72. STEEG, P.S., BEVILACQUA, G., KOPPER, L., THORGEIRSSON, U.P., TALMADGE, J.E., LIOTTA, L.A., and SOBEL, M.E. Evidence for a novel gene associated with low tumor metastatic potential. J. Natl. Cancer Inst. 80, 200-204, 1988.
73. STEIN, G.H. and YANISHEVSKY, R.M. Quiescent human diploid cells can inhibit entry into S phase in replicative nuclei in heterodikaryons. Proc. Natl. Acad. Sci. USA 78, 3025-3029, 1981.
74. SUKHATME, V.P., CAO, X., CHANG, L.C., TSAI-MORRIS, C., STAMENKOWICH, D., FERREIRA, P.C.P., COHEN, D.R., EDWARDS, S.A., SHOWS, T.B., CURRAN, T., LE BAU, M.M., and ADAMSON, E.D. A zinc finger-encoding gene coregulated with c-fos during growth and differentiation, and after cellular differentiation. Cell 56, 337-343, 1988.
75. SWAROOP, A., HOGAN, B.L.M., and FRANCKE, U. Molecular analysis of the cDNA for human SPARC/osteonectin/ BM-40: Sequence, expression and localization of the gene to chromosome 5q31-q33. Genomics 2, 37-47, 1988.
76. SYMINGTON, B.E. Fibronectin receptor modulates cyclin-dependent kinase activity. J. Biol. Chem. 267, 25744-25747, 1992.
77. TANAKA, K., NAKAZAWA, T., OKADA, Y., and KUMAHARA, Y. Roles of nuclear and cytoplasmic environments in the retarded DNA synthesis in Werner syndrome cells. Exp. Cell Res. 127, 185-190, 1980.
78. TATSUKA, M., MITSUI, H., WADA, M., NAGATA, A., NOJIMA, H., and OKAYAMA, H. Elongation factor-1α gene determines susceptibility to transformation. Nature 359, 333-336, 1992.
79. TAUTZ, D., LEHMANN, R., SCHNURCH, H., SCHUH, R., SEIFERT, E., KIENLIN, A., JONES, K., and JACKLE, H. Finger protein of novel structure encoded by hunchback, a second member of the gap class of Drosophila segmentation genes. Nature 327, 383-389, 1987.
80. THWEATT, R. and GOLDSTEIN, S. Werner syndrome and biological aging: A molecular genetic hypothesis. BioEssays 15, 421-426, 1993.
81. THWEATT, R., LUMPKIN, C. K., and GOLDSTEIN, S. A novel gene encoding a smooth muscle protein is overexpressed in senescent human fibroblasts. Biochem. Biophys. Res. Commun. 187, 1-7, 1992.
82. UETSUKI, T., NAITO, A., NAGATA, S., and KAZIRO, Y. Isolation and characterization of the human chromosomal gene for polypeptide chain elongation factor 1-α. J. Biol. Chem. 264, 5791-5798, 1989.
83. WANG, L., PATEL, U., GHOSH, L., CHEN, H.C., and BANERJEE, S. Mutation in the nm23 gene is associated with metastasis in colorectal cancer. Cancer Res. 53, 717-720, 1993.
84. WANG, X., LEE, G., LIEBHABER, S.A., and COOKE, N.E. Human cysteine-rich protein: A member of the LIM/ double-finger family displaying coordinate serum induction with c-myc. J. Biol. Chem. 267, 9176-9184, 1992.
85. WHARTON, K.A., JOHANSEN, K.M., XU, T., and ARTAVANIS-TSAKONAS, S. Nucleotide sequence from the neurogenic locus Notch implies a gene product that shares homology with proteins containing EGF-like repeats. Cell 43, 567-581, 1985.
86. WITZGALL, R., O'LEARY, E., GESSNER, R., OUELLETTE, A.J., and BONVENTRE, J.V. Kid-1, a putative renal transcription factor: Regulation during ontogeny and in response to ischemia and toxic injury. Mol. Cell. Biol. 13, 1933-1942, 1993.