-
1
-
-
0034610973
-
High frequency of autoreactive myelin proteolipid protein-specific T cells in the periphery of naive mice: Mechanisms of selection of the self-reactive repertoire
-
Anderson, A. C., L. B. Nicholson, K. L. Legge, V. Turchin, H. Zaghouani, and V. K. Kuchroo. 2000. High frequency of autoreactive myelin proteolipid protein-specific T cells in the periphery of naive mice: mechanisms of selection of the self-reactive repertoire. J. Exp. Med. 191: 761-770.
-
(2000)
J. Exp. Med.
, vol.191
, pp. 761-770
-
-
Anderson, A.C.1
Nicholson, L.B.2
Legge, K.L.3
Turchin, V.4
Zaghouani, H.5
Kuchroo, V.K.6
-
2
-
-
0033984067
-
Shaping of the autoreactive T-cell repertoire by a splice variant of self protein expressed in thymic epithelial cells
-
Klein, L., M. Klugmann, K. A. Nave, V. K. Tuohy, and B. Kyewski. 2000. Shaping of the autoreactive T-cell repertoire by a splice variant of self protein expressed in thymic epithelial cells. Nat. Med. 6: 56-61.
-
(2000)
Nat. Med.
, vol.6
, pp. 56-61
-
-
Klein, L.1
Klugmann, M.2
Nave, K.A.3
Tuohy, V.K.4
Kyewski, B.5
-
3
-
-
0037383758
-
Aire regulates negative selection of organ-specific T cells
-
Liston, A., S. Lesage, J. Wilson, L. Peltonen, and C. C. Goodnow. 2003. Aire regulates negative selection of organ-specific T cells. Nat. Immunol. 4: 350-354.
-
(2003)
Nat. Immunol.
, vol.4
, pp. 350-354
-
-
Liston, A.1
Lesage, S.2
Wilson, J.3
Peltonen, L.4
Goodnow, C.C.5
-
4
-
-
0030806085
-
In thymic selection, peptide diversity gives and takes away
-
Bevan, M. J. 1997. In thymic selection, peptide diversity gives and takes away. Immunity 7: 175-178.
-
(1997)
Immunity
, vol.7
, pp. 175-178
-
-
Bevan, M.J.1
-
5
-
-
0033581935
-
Selecting and maintaining a diverse T-cell repertoire
-
Goldrath, A. W., and M. J. Bevan. 1999. Selecting and maintaining a diverse T-cell repertoire. Nature 402: 255-262.
-
(1999)
Nature
, vol.402
, pp. 255-262
-
-
Goldrath, A.W.1
Bevan, M.J.2
-
6
-
-
0036219003
-
T cell response in experimental autoimmune encephalomyelitis (EAE): Role of self and cross-reactive antigens in shaping, tuning and regulating the autopathogenic T cell repertoire
-
Kuchroo, V. K., A. C. Anderson, H. Waldner, M. Munder, E. Bettelli, and L. B. Nicholson. 2002. T cell response in experimental autoimmune encephalomyelitis (EAE): role of self and cross-reactive antigens in shaping, tuning and regulating the autopathogenic T cell repertoire. Annu. Rev. Immunol. 20: 101-123.
-
(2002)
Annu. Rev. Immunol.
, vol.20
, pp. 101-123
-
-
Kuchroo, V.K.1
Anderson, A.C.2
Waldner, H.3
Munder, M.4
Bettelli, E.5
Nicholson, L.B.6
-
7
-
-
0025755292
-
Ablation of "tolerance" and induction of diabetes by virus infection in viral antigen transgenic mice
-
Ohashi, P. S., S. Oehen, K. Buerki, H. Pircher, C. T. Ohashi, B. Odermatt, B. Malissen, R. M. Zinkernagel, and H. Hengartner. 1991. Ablation of "tolerance" and induction of diabetes by virus infection in viral antigen transgenic mice. Cell 65: 305-317.
-
(1991)
Cell
, vol.65
, pp. 305-317
-
-
Ohashi, P.S.1
Oehen, S.2
Buerki, K.3
Pircher, H.4
Ohashi, C.T.5
Odermatt, B.6
Malissen, B.7
Zinkernagel, R.M.8
Hengartner, H.9
-
8
-
-
0025754853
-
Virus infection triggers insulin-dependent diabetes mellitus in a transgenic model: Role of anti-self (virus) immune response
-
Oldstone, M. B., M, Nerenberg, P, Southern, J. Price, and H. Lewicki. 1991. Virus infection triggers insulin-dependent diabetes mellitus in a transgenic model: role of anti-self (virus) immune response. Cell 65: 319-331.
-
(1991)
Cell
, vol.65
, pp. 319-331
-
-
Oldstone, M.B.1
Nerenberg, M.2
Southern, P.3
Price, J.4
Lewicki, H.5
-
9
-
-
0025872395
-
Down-regulation of Tcell receptors on self-reactive T cells as a novel mechanism for extrathymic tolerance induction
-
Schonrich, G., U. Kalinke, F. Momburg, M. Malissen, A. M. Schmitt-Verhulst, B. Malissen, G. J. Hammerling, and B. Arnold. 1991. Down-regulation of Tcell receptors on self-reactive T cells as a novel mechanism for extrathymic tolerance induction. Cell 65: 293-304.
-
(1991)
Cell
, vol.65
, pp. 293-304
-
-
Schonrich, G.1
Kalinke, U.2
Momburg, F.3
Malissen, M.4
Schmitt-Verhulst, A.M.5
Malissen, B.6
Hammerling, G.J.7
Arnold, B.8
-
10
-
-
0029121077
-
Down-regulation of CD8 on mature antigen-reactive T cells as a mechanism of peripheral tolerance
-
Zhang, L., W. Fung-Leung, and R. G. Miller. 1995. Down-regulation of CD8 on mature antigen-reactive T cells as a mechanism of peripheral tolerance. J. Immunol. 155: 3464-3471.
-
(1995)
J. Immunol.
, vol.155
, pp. 3464-3471
-
-
Zhang, L.1
Fung-Leung, W.2
Miller, R.G.3
-
11
-
-
0037133268
-
Interactions between double positive thymocytes and high-affinity ligands presented by cortical epithelial cells generate double negative thymocytes with T cell regulatory activity
-
Wang, R., Y. Wang-Zhu, and H. Grey. 2002, Interactions between double positive thymocytes and high-affinity ligands presented by cortical epithelial cells generate double negative thymocytes with T cell regulatory activity. Proc. Natl. Acad. Sci. USA 99: 2181-2186.
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 2181-2186
-
-
Wang, R.1
Wang-Zhu, Y.2
Grey, H.3
-
12
-
-
0025693909
-
Peripheral clonal elimination of functional T cells
-
Jones, L. A., L. T. Chin, D. L. Longo, and A. M. Kruisbeek. 1990. Peripheral clonal elimination of functional T cells. Science 250: 1726-1729.
-
(1990)
Science
, vol.250
, pp. 1726-1729
-
-
Jones, L.A.1
Chin, L.T.2
Longo, D.L.3
Kruisbeek, A.M.4
-
15
-
-
0023143676
-
Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo
-
Jenkins, M. K., and R. H. Schwanz. 1987. Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo. J. Exp. Med. 165: 302-319.
-
(1987)
J. Exp. Med.
, vol.165
, pp. 302-319
-
-
Jenkins, M.K.1
Schwanz, R.H.2
-
16
-
-
0024327899
-
Clonal expansion versus functional clonal inactivation: A costimulatory signaling pathway determines the outcome of T cell antigen receptor occupancy
-
Mueller, D. L., M. K. ienkins, and R. H. Schwanz. 1989. Clonal expansion versus functional clonal inactivation: a costimulatory signaling pathway determines the outcome of T cell antigen receptor occupancy. Annu. Rev. Immunol. 7: 445-480.
-
(1989)
Annu. Rev. Immunol.
, vol.7
, pp. 445-480
-
-
Mueller, D.L.1
Ienkins, M.K.2
Schwanz, R.H.3
-
17
-
-
0025339511
-
A cell culture model for T lymphocyte clonal anergy
-
Schwanz, R. H. 1990. A cell culture model for T lymphocyte clonal anergy. Science 248: 1349-1356.
-
(1990)
Science
, vol.248
, pp. 1349-1356
-
-
Schwanz, R.H.1
-
18
-
-
0027532184
-
Clonal anergy blocks in vivo growth of mature T cells and can be reversed in the absence of antigen
-
Rocha, B., C. Tanchot, and H. von Boehmer. 1993. Clonal anergy blocks in vivo growth of mature T cells and can be reversed in the absence of antigen. J. Exp. Med. 177: 1517-1521.
-
(1993)
J. Exp. Med.
, vol.177
, pp. 1517-1521
-
-
Rocha, B.1
Tanchot, C.2
Von Boehmer, H.3
-
20
-
-
0030029974
-
Peripheral tolerance in T cell receptor-transgenic mice: Evidence for T cell anergy
-
Published erratum appears in 1996 Eur. J. Immunol. 26: 966
-
Falb, D., T. J. Briner, G. H. Sunshine, C. R. Bourque, M. Luqman, M. L. Gefter, and T. Kamradt. 1996. Peripheral tolerance in T cell receptor-transgenic mice: evidence for T cell anergy. [Published erratum appears in 1996 Eur. J. Immunol. 26: 966.] Eur. J. Immunol. 26: 130-135.
-
(1996)
Eur. J. Immunol.
, vol.26
, pp. 130-135
-
-
Falb, D.1
Briner, T.J.2
Sunshine, G.H.3
Bourque, C.R.4
Luqman, M.5
Gefter, M.L.6
Kamradt, T.7
-
21
-
-
0030852519
-
A range of CD4 T cell tolerance: Partial activation to organ-specific antigen allows nondestructive thyroiditis or insuiitis
-
Akkaraju, S., W. Y. Ho, D. Leong, K. Canaan, M. M. Davis, and C. C. Goodnow. 1997. A range of CD4 T cell tolerance: partial activation to organ-specific antigen allows nondestructive thyroiditis or insuiitis. Immunity 7: 255-271.
-
(1997)
Immunity
, vol.7
, pp. 255-271
-
-
Akkaraju, S.1
Ho, W.Y.2
Leong, D.3
Canaan, K.4
Davis, M.M.5
Goodnow, C.C.6
-
23
-
-
0026047598
-
Altered antigen receptor signaling in anergic T cells from self-tolerant T-cell receptor B-chain transgenic mice
-
Blackman, M. A., T. H. Finkel, J. Kappler, J. Cambier, and P. Marrack. 1991. Altered antigen receptor signaling in anergic T cells from self-tolerant T-cell receptor B-chain transgenic mice. Proc. Natl. Acad. Sci. USA 88: 6682-6686.
-
(1991)
Proc. Natl. Acad. Sci. USA
, vol.88
, pp. 6682-6686
-
-
Blackman, M.A.1
Finkel, T.H.2
Kappler, J.3
Cambier, J.4
Marrack, P.5
-
24
-
-
0027308742
-
The fate of anergic T cells in vivo
-
Migita, K., and A. Ochi. 1993. The fate of anergic T cells in vivo. J. Immunol. 150: 763-770.
-
(1993)
J. Immunol.
, vol.150
, pp. 763-770
-
-
Migita, K.1
Ochi, A.2
-
25
-
-
0028060199
-
Exogeneous superarttigens acutely trigger distinct levels of peripheral T cell tolerance/immunosuppressiori: Dose-response relationship
-
Miethke, T., C. Wahl, H. Gaus, K. Heeg, and H. Wagner. 1994. Exogeneous superarttigens acutely trigger distinct levels of peripheral T cell tolerance/immunosuppressiori: dose-response relationship. Eur. J. Immunol. 24: 1893-1902.
-
(1994)
Eur. J. Immunol.
, vol.24
, pp. 1893-1902
-
-
Miethke, T.1
Wahl, C.2
Gaus, H.3
Heeg, K.4
Wagner, H.5
-
26
-
-
0027322028
-
Superantigen-induced peripheral tolerance inhibits T cell responses to immunogenic peptides in TCR (β-chain) transgenic mice
-
Perkins, D. L., Y. Wang, S. Ho, G. R. Wiens, J. G. Seidman, and I. J. Rimm. 1993. Superantigen-induced peripheral tolerance inhibits T cell responses to immunogenic peptides in TCR (β-chain) transgenic mice. J. Immunol. 150: 4284-4291.
-
(1993)
J. Immunol.
, vol.150
, pp. 4284-4291
-
-
Perkins, D.L.1
Wang, Y.2
Ho, S.3
Wiens, G.R.4
Seidman, J.G.5
Rimm, I.J.6
-
27
-
-
0033400631
-
Molecular pathogenesis of multiple sclerosis
-
Bar-Or, A., E. M. Oliveira, D. E. Anderson, and D. A. Hafler. 1999. Molecular pathogenesis of multiple sclerosis, J. Neuroimmunol. 100: 252-259.
-
(1999)
J. Neuroimmunol.
, vol.100
, pp. 252-259
-
-
Bar-Or, A.1
Oliveira, E.M.2
Anderson, D.E.3
Hafler, D.A.4
-
28
-
-
0034947448
-
A virus-induced molecular mimicry model of multiple sclerosis
-
Olson, J.K., J. L. Croxford, M. A. Calenoff, M. C. Dal Canto, and S. D. Miller. 2001. A virus-induced molecular mimicry model of multiple sclerosis. J. Clin. Invest. 108: 311-318.
-
(2001)
J. Clin. Invest.
, vol.108
, pp. 311-318
-
-
Olson, J.K.1
Croxford, J.L.2
Calenoff, M.A.3
Dal Canto, M.C.4
Miller, S.D.5
-
29
-
-
0037020853
-
Reduced self-reactivity of an autoreactive T cell after activation with cross-reactive non-self-ligand
-
Munder, M., E. Bettelli, L. Monney, J. M. Slavik, L. B. Nicholson, and V. K. Kuchroo. 2002. Reduced self-reactivity of an autoreactive T cell after activation with cross-reactive non-self-ligand. J. Exp. Med. 196: 1151-1162.
-
(2002)
J. Exp. Med.
, vol.196
, pp. 1151-1162
-
-
Munder, M.1
Bettelli, E.2
Monney, L.3
Slavik, J.M.4
Nicholson, L.B.5
Kuchroo, V.K.6
-
30
-
-
0031935753
-
Heteroclitic proliferative responses and changes in cytokine profile induced by altered peptides: Implications for autoimmunity
-
Nicholson, L. B., H. Waldner, A. M. Carrizosa, A. Sette, M. Collins, and V. K. Kuchroo. 1998. Heteroclitic proliferative responses and changes in cytokine profile induced by altered peptides: implications for autoimmunity. Proc. Natl. Acad. Sci. USA 95: 264-269.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 264-269
-
-
Nicholson, L.B.1
Waldner, H.2
Carrizosa, A.M.3
Sette, A.4
Collins, M.5
Kuchroo, V.K.6
-
31
-
-
0028466130
-
Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo
-
Kearney, E., K. Pape, D. Loh, and M. Jenkins. 1994. Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo. Immunity 1: 327-339.
-
(1994)
Immunity
, vol.1
, pp. 327-339
-
-
Kearney, E.1
Pape, K.2
Loh, D.3
Jenkins, M.4
-
32
-
-
0023715475
-
Unresponsiveness to a foreign antigen can be caused by self-tolerance
-
Vidovic, D., and P. Matzinger. 1988. Unresponsiveness to a foreign antigen can be caused by self-tolerance. Nature 336: 222-225.
-
(1988)
Nature
, vol.336
, pp. 222-225
-
-
Vidovic, D.1
Matzinger, P.2
-
33
-
-
0032526853
-
Endogeneous myelin basic protein inactivates the high avidity T cell repertoire
-
Targoni, O. S., and P. V. Lehmann. 1998. Endogeneous myelin basic protein inactivates the high avidity T cell repertoire. J. Exp. Med. 187: 2055-2063.
-
(1998)
J. Exp. Med.
, vol.187
, pp. 2055-2063
-
-
Targoni, O.S.1
Lehmann, P.V.2
-
34
-
-
0029878442
-
Tolerance is overcome in beef insulin-transgenic mice by activation of low-affinity autoreactive T cells
-
Poplonski, L., B. Vukusic, J. Pawling, S. Clapoff, J. Roder, N. Hozumi, and J. Wither. 1996. Tolerance is overcome in beef insulin-transgenic mice by activation of low-affinity autoreactive T cells. Eur. J. Immunol. 26: 601-609.
-
(1996)
Eur. J. Immunol.
, vol.26
, pp. 601-609
-
-
Poplonski, L.1
Vukusic, B.2
Pawling, J.3
Clapoff, S.4
Roder, J.5
Hozumi, N.6
Wither, J.7
-
35
-
-
0030892137
-
Tolerance to p53 by A2.1-restricted cytotoxic T lymphocytes
-
Theobald, M., J. Biggs, J. Hernandez, J. Lustgarten, C. Labadie, and L. A. Sherman. 1997. Tolerance to p53 by A2.1-restricted cytotoxic T lymphocytes. J. Exp. Med. 185: 833-841.
-
(1997)
J. Exp. Med.
, vol.185
, pp. 833-841
-
-
Theobald, M.1
Biggs, J.2
Hernandez, J.3
Lustgarten, J.4
Labadie, C.5
Sherman, L.A.6
-
36
-
-
0032529387
-
Termination of peripheral tolerance to a T cell epitope by heteroclitic antigen analogues
-
Zügel, U., R. Wang, G. Shih, A. Sette, J. Alexander, and H. M. Grey. 1998. Termination of peripheral tolerance to a T cell epitope by heteroclitic antigen analogues. J. Immunol. 161: 1705-1709.
-
(1998)
J. Immunol.
, vol.161
, pp. 1705-1709
-
-
Zügel, U.1
Wang, R.2
Shih, G.3
Sette, A.4
Alexander, J.5
Grey, H.M.6
-
37
-
-
0033523640
-
The stimulation of low-affinity, nontolerized clones by heteroclitic antigen analogues causes breaking of tolerance established to an immunodominant T cell epitope
-
Wang, R., Y. Wang-Zhu, C. R. Gabaglia, K. Kimachi, and H. M. Grey. 1999. The stimulation of low-affinity, nontolerized clones by heteroclitic antigen analogues causes breaking of tolerance established to an immunodominant T cell epitope. J. Exp. Med. 190: 983-994.
-
(1999)
J. Exp. Med.
, vol.190
, pp. 983-994
-
-
Wang, R.1
Wang-Zhu, Y.2
Gabaglia, C.R.3
Kimachi, K.4
Grey, H.M.5
-
38
-
-
0031038173
-
Induction of apoptosis and T helper 2 (Th2) responses correlates with peptide affinity for the major histocompatibility complex in self-reactive T cell receptor transgenic mice
-
Pearson, C. I., W. van Ewijk, and H. O. McDewitt. 1997. Induction of apoptosis and T helper 2 (Th2) responses correlates with peptide affinity for the major histocompatibility complex in self-reactive T cell receptor transgenic mice. J. Exp. Med. 185: 583-599.
-
(1997)
J. Exp. Med.
, vol.185
, pp. 583-599
-
-
Pearson, C.I.1
Van Ewijk, W.2
McDewitt, H.O.3
-
39
-
-
0031964338
-
Interleukin 10 secretion and impaired effector function of major histocompatibility complex class II-restricted T cells anergized in vivo
-
Buer, J., A. Lanoue, A. Franzke, C. Garcia, H. von Boehmer, and A. Sarukhan. 1998, Interleukin 10 secretion and impaired effector function of major histocompatibility complex class II-restricted T cells anergized in vivo. J. Exp. Med. 187: 177-183.
-
(1998)
J. Exp. Med.
, vol.187
, pp. 177-183
-
-
Buer, J.1
Lanoue, A.2
Franzke, A.3
Garcia, C.4
Von Boehmer, H.5
Sarukhan, A.6
-
40
-
-
0030636560
-
Immunoregulatoty role of IL-10 during superantigen-induced hyporesponsiveness in vivo
-
Sundstedt, A., I. Höidén, A. Rosendahl, T. Kalland, N. van Rooijen, and M. Dohlsten. 1997. Immunoregulatoty role of IL-10 during superantigen-induced hyporesponsiveness in vivo. J. Immunol. 158: 180-186.
-
(1997)
J. Immunol.
, vol.158
, pp. 180-186
-
-
Sundstedt, A.1
Höidén, I.2
Rosendahl, A.3
Kalland, T.4
Van Rooijen, N.5
Dohlsten, M.6
-
41
-
-
0028158319
-
High levels of IL-10 production in vivo are associated with tolerance in SCID patients transplanted with HLA mismatched hematopoetic stem cells
-
Bachetta, R., M. Bigler, J. L. Touraine, R. Parkman, P. A. Tovo, J. Abrams, and M. G. Roncarolo. 1994. high levels of IL-10 production in vivo are associated with tolerance in SCID patients transplanted with HLA mismatched hematopoetic stem cells. J. Exp. Med. 179: 493-502.
-
(1994)
J. Exp. Med.
, vol.179
, pp. 493-502
-
-
Bachetta, R.1
Bigler, M.2
Touraine, J.L.3
Parkman, R.4
Tovo, P.A.5
Abrams, J.6
Roncarolo, M.G.7
-
42
-
-
0026434554
-
Separation of IL-4 production from Th cell proliferation by an altered T cell receptor ligand
-
Evavold, B. D., and P. M. Allen. 1991. Separation of IL-4 production from Th cell proliferation by an altered T cell receptor ligand. Science 252: 1308-1310.
-
(1991)
Science
, vol.252
, pp. 1308-1310
-
-
Evavold, B.D.1
Allen, P.M.2
-
43
-
-
0032526345
-
Relationships among TCR ligand potency, thresholds for effector function elicitation, and the quality of early signaling events in human T cells
-
Hemmer, B., I. Stefanova, M. Vergelli, R. N. Germain, and R. Martin. 1998. Relationships among TCR ligand potency, thresholds for effector function elicitation, and the quality of early signaling events in human T cells. J. Immunol. 160: 5807-5814.
-
(1998)
J. Immunol.
, vol.160
, pp. 5807-5814
-
-
Hemmer, B.1
Stefanova, I.2
Vergelli, M.3
Germain, R.N.4
Martin, R.5
-
47
-
-
0036533515
-
+ T cells exhibit distinct expression patterns of cytokines and cell surface molecules on their primary responses to varying doses of antigen
-
+ T cells exhibit distinct expression patterns of cytokines and cell surface molecules on their primary responses to varying doses of antigen. J. Immunol. 168: 3242-3250.
-
(2002)
J. Immunol.
, vol.168
, pp. 3242-3250
-
-
Ise, W.1
Totsuka, M.2
Sogawa, Y.3
Ametani, A.4
Hachimura, S.5
Sato, T.6
Kumagai, Y.7
Habu, S.8
Kaminogawa, S.9
-
48
-
-
0030738659
-
Treatment of experimental autoimmune encephalomyelitis with genetically modified memory T cells
-
Mathisen, P. M., M. Yu, J. M. Johnson, J. A. Drazba, and V. Tuohy. 1997. Treatment of experimental autoimmune encephalomyelitis with genetically modified memory T cells. J. Exp. Med. 186: 159-164.
-
(1997)
J. Exp. Med.
, vol.186
, pp. 159-164
-
-
Mathisen, P.M.1
Yu, M.2
Johnson, J.M.3
Drazba, J.A.4
Tuohy, V.5
-
50
-
-
0032193696
-
IL-10 is critical in the regulation of autoimmune encephalomyelitis as demonstrated by studies of IL-10- And IL-4-deficient and transgenic mice
-
Bettelli, E., M. P. Das, E. D. Howard, H. L. Weiner, R. A. Sobel, and V. K. Kuchroo. 1998. IL-10 is critical in the regulation of autoimmune encephalomyelitis as demonstrated by studies of IL-10- and IL-4-deficient and transgenic mice. J. Immunol. 161:3299-3306.
-
(1998)
J. Immunol.
, vol.161
, pp. 3299-3306
-
-
Bettelli, E.1
Das, M.P.2
Howard, E.D.3
Weiner, H.L.4
Sobel, R.A.5
Kuchroo, V.K.6
|