Tolerance is overcome in beef insulin-transgenic mice by activation of low-affinity autoreactive T cells

European Journal of Immunology

Volumn 26, Issue 3, 1996, Pages 601-609

  Poplonski, Lorraine ^a   Vukusic, Brian ^a   Pawling, Judy ^b   Clapoff, Susan ^b   Roder, John ^b,c   Hozumi, Nobu ^b,c   Wither, Joan ^a,c  

^a TORONTO WESTERN HOSPITAL   (Canada)

^b MOUNT SINAI HOSPITAL   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

Insulin; T cell receptor; Tolerance; Transgenic mice

Indexed keywords

BOVINE INSULIN; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A; IMMUNOGLOBULIN G2B; INTERLEUKIN 2; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY PRODUCTION; ARTICLE; CONTROLLED STUDY; HYBRIDOMA; IMMUNIZATION; IMMUNOLOGICAL TOLERANCE; INSULIN RELEASE; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; T LYMPHOCYTE ACTIVATION; TRANSGENE;

AMINO ACID SEQUENCE; ANIMALS; AUTOANTIGENS; FEMALE; IMMUNE TOLERANCE; INSULIN; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; MICE, TRANSGENIC; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; T-LYMPHOCYTES;

EID: 0029878442     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.1830260315     Document Type: Article

References (38)

1. Kappler, J., Roehm, N. and Marrack, P., Cell 1987. 49:273.
2. Kisielow, P., Bluthmann, H., Staerz, U., Steinmetz, M. and von Boehmer, H., Nature 1988. 333:742.
3. Sha, W.C., Nelson, C.A., Newberry, R.D., Kranz, D.M., Russell, J.H. and Loh, D.Y., Nature 1988. 336:73.
4. Miller, J.F.A.P. and Morahan, G., Annu. Rev. Immunol. 1992. 10:51.
5. Ohashi, P.S., Oehen, S., Buerkin, K., Pircher, H., Ohashi, C.T., Odermatt, B., Malisson, B., Zinkernagel, R.M. and Hengartner, H., Cell. 1991. 65:305.
6. Jones, L.A., Chin, L.T., Longo, D.L. and Kruisbeek, A.M., Science 1990. 250:1726.
7. Bloom, B.R., Modlin, R.L. and Salgane, P., Annu. Rev. Immunol. 1992. 10:453.
8. Eynon, E.E. and Parker, D.C., J. Exp. Med. 1992. 775:131.
9. Burstein, H.J., Shea, C.M. and Abbas, A.K., J. Immunol. 1992. 148:3687.
10. De Wit, D., Van Mechelen, M., Ryelandt, M., Figueiredo, A.C., Abramowicz, D., Goldman, M., Bazin, H., Urbain. J. and Leo. O., J. Exp. Med. 1992. 175:9.
11. Romball, C.G. and Weigle, W.O., J. Exp. Med. 1993. 178:1637.
12. Murphy, K.M., Heimberger, A.B. and Loh, D.Y., Science 1990. 250:1720.
13. Bell, G.I., Pictet, R.L., Rutter, W.J., Cordell, B., Tischer, E. and Goodman, H.M., Nature 1980. 284:26.
14. Selden, R.F., Skoskiewicz, M.J., Howie, K.B., Russell, P.S. and Goodman, H.M., Nature 1986. 321:525.
15. Jensen, P.E., Pierce, C.W. and Kapp, J.A., J. Exp. Med. 1984. 760:1012.
16. Wither, J., Pawling, J., Phillips, L., Delovitch, T. and Hozumi, N., J. Immunol. 1991. 746:3513.
17. Shimonkevitz, R., Kappler, J., Marrack, P. and Grey, H. J. Exp. Med. 1983. 755:303.
18. Jensen, P.E., J. Exp. Med. 1991. 174:1121.
19. Chomczynski, P. and Sacchi, N., Anal. Biochem. 1987. 162:156.
20. Seiden, R.F., Skoskiewicz, M.J., Russell, P.S. and Goodman, H.M., N. Engl. J. Med. 1987. 317:1067.
21. Bucchini, D., Ripoche, M.-A., Stinnakre, M.-G., Desbois, P., Lores, P., Monthioux, E., Absil, J., Lepesant, J.-A., Pictet, R. and Jami, J., Proc. Natl. Acad. Sci. USA 1986. 83:2511.
22. Snapper, C.M. and Paul, W.E., Science 1987. 256:944.
23. Cibotti, R., Kanellopoulos, J.M., Cabaniols, J.-P., Halle-Panenko, O., Kosmatopoulos, K., Sercarz, E. and Kourilsky, P., Proc. Natl. Acad. Sci. USA 1992. 59:416.
24. Williams, D.B., Ferguson, J., Gariepy, J., McKay, D., Teng, Y.-T., Iwasaki, S. and Hozumi, N., J. Immunol. 1993. 151:3627.
25. Vukusic, B., Poplonski, L., Phillips, L., Pawling, J., Delovitch, T., Hozumi, N. and Wither, J., Mol. Immunol. 1996, in press.
26. Chou, H.S., Behlke, M.A., Godambe, S.A., Russell, J.H., Brooks, C.G. and Loh, D.Y., EMBO J. 1986. 5:2149.
27. Koop, B.F., Wilson, R.K., Wang, K., Vernooij, B., Zaller, D., Chia, L.K., Seto, D., Toda, M. and Hood, L., Genomics 1992. 13:1209.
28. Barth, R.K., Kim, B.S., Lan, N.C., Hunkapiller, T., Sobieck, N., Winoto, A., Gershenfeld, H., Okada, C., Hansburg, D., Weissman, I.L. and Hood, L., Nature 1985. 316:517.
29. Malissen, M., McCoy, C., Blanc, D., Trucy, J., Devaux, C., Schmitt-Verhulst, A.-M., Fitch, F., Hood, L. and Malissen, B., Nature 1986. 319:28.
30. Gascoigne, N.R.J., Chien, Y.-H., Becker, D.M., Kavaler, J. and Davis, M.M., Nature 1984. 310:387.
31. Kavaler, J., Davis, M.M. and Chien, Y.-H., Nature 1984. 310:421.
32. Whitely, P.J., Poindexter, N.J., Landon, C. and Kapp, J.A., J. Immunol. 1990. 145:1376.
33. Poindexter, N.J., Landon, C., Whiteley, P.J. and Kapp, J.A., J. Immunol. 1992. 149:38.
34. Cibotti, R., Cabaniols, J.-P., Pannetier, C., Delarbe, C., Vergnon, I., Kaneliopoulos, J.M. and Kourilsky, R. J. Exp. Med. 1994. 180:861.
35. Yule, T.D., Basten, A. and Allen, P.M., J. Immunol. 1993. 151:3057.
36. Paslay, J.W. and Roozen, K.J., in Hämmerling, G.J., Hämmerling, U. and Kearney, J.K. (Eds.), Monoclonal Antibodies and B cell Hybridomas. Elsevier/North Holland Biomedical Press, New York 1981, p.551.
37. Whitely, P.J., Jensen, P.E., Pierce, C.W., Abruzzini, A.F. and Kapp, J.A., Proc. Natl. Acad. Sci. USA 1988. 85:2723.
38. Wegmann, D.R., Norbury-Glaser, M. and Daniel, D., Eur. J. Immunol. 1994. 24: 1853.