Guanine-specific oxidation of double-stranded DNA by Cr(VI) and ascorbic acid forms spiroiminodihydantoin and 8-oxo-2′-deoxyguanosine

Chemical Research in Toxicology

Volumn 18, Issue 7, 2005, Pages 1140-1149

  Slade, Peter G ^a   Hailer, M Katie ^a   Martin, Brooke D ^a   Sugden, Kent D ^a  

^a UNIVERSITY OF MONTANA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; ASCORBIC ACID; CHROMIUM DERIVATIVE; DOUBLE STRANDED DNA; GUANINE; HYDANTOIN DERIVATIVE; NUCLEIC ACID BASE; SPIROIMINODIHYANDANTOIN; UNCLASSIFIED DRUG;

ARTICLE; CARCINOGENICITY; CONCENTRATION RESPONSE; DNA DAMAGE; ENZYME ACTIVITY; EXCISION REPAIR; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MUTAGENICITY; OXIDATION; SEQUENCE ANALYSIS;

ASCORBIC ACID; CHROMIUM; DEOXYGUANOSINE; DNA; DNA GLYCOSYLASES; DNA REPAIR; GUANINE; GUANOSINE; MOLECULAR STRUCTURE; OXIDATION-REDUCTION; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPIRO COMPOUNDS;

EID: 22544434922     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx050033y     Document Type: Article

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