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From Berry Co., Dexter, MI, purity "100%" (HPLC)
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From Berry Co., Dexter, MI, purity "100%" (HPLC).
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29
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0343156929
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The spectra of oxidized 8-OHdGuo at pH 3, 7.7, and 13.3 are available in Supporting Information
-
The spectra of oxidized 8-OHdGuo at pH 3, 7.7, and 13.3 are available in Supporting Information.
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30
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0000288179
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under the same conditions, it was established (the conductance signals had the same shape and amplitude within ±49%) that the species existing at pH < 6 is the radical cation of 8-OHdG
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·- at pH 4.5 to one-electron-oxidue 8-OHdG and, for calibration, anisole radical cation (O'Neill, P.; Steenken, S.; Schulte-Frohlinde, D. J. Phys. Chem. 1975, 79, 2773)) under the same conditions, it was established (the conductance signals had the same shape and amplitude within ±49%) that the species existing at pH < 6 is the radical cation of 8-OHdG.
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0016854447
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The reactions of enolether radical cations with the guanine moiety are relevant because enolether radical cations are formed in DNA as a result of C4′-radical initiated chain breaks (Dizdaroglu, M.; von Sonntag, C.; Schulte-Frohlinde, D. J. Am. Chem. Soc. 1975, 97, 2277; Giese, B.; Beyrich-Graf, X.; Erdmann, P.; Petretta, M.; Schwitter, U. Chem. Biol. 1995, 2, 367).
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0029310521
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The reactions of enolether radical cations with the guanine moiety are relevant because enolether radical cations are formed in DNA as a result of C4′-radical initiated chain breaks (Dizdaroglu, M.; von Sonntag, C.; Schulte- Frohlinde, D. J. Am. Chem. Soc. 1975, 97, 2277; Giese, B.; Beyrich-Graf, X.; Erdmann, P.; Petretta, M.; Schwitter, U. Chem. Biol. 1995, 2, 367).
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0342722465
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note
-
4 as electrolyte. The (reversible) value was found to be independent of pH in the range 1-12. We thank Dr. E. Bothe for performing this experiment.
-
-
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-
40
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0001316270
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Merenyi, G.; Lind, J.; Shen, X. J. Phys. Chem. 1988, 92, 134.
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42
-
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0343156921
-
-
note
-
0, results as 1.18 V/NHE taking into account the three different protonation states of the 8-OHdG radical shown in Scheme 1.
-
-
-
-
43
-
-
0342287368
-
-
note
-
The difference in the (irreversible) "half peak" potentials in DMF has been measured to be 0.43 V (ref 14).
-
-
-
-
44
-
-
0343592417
-
-
As shown in ref 26, stacking of 8-OHdG with G does not change the relative potential of G and 8-OHdG moieties
-
As shown in ref 26, stacking of 8-OHdG with G does not change the relative potential of G and 8-OHdG moieties.
-
-
-
-
45
-
-
0343592416
-
-
note
-
Although the redox potentials of the bases in the DNA polymer are not known, it is likely that the change from aqueous to "DNA phase" or stacking interactions (ref 26) do not change the relative potentials.
-
-
-
-
46
-
-
0342722460
-
-
note
-
Similar ideas have been put foreward previously (refs 14, 21, 23-26).
-
-
-
-
47
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0000095341
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Jovanovic, S. V.; Jankovic, I.; Josimovic, L. J. Am. Chem. Soc. 1992, 114, 9018.
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