Thyme (Thymus vulgaris L.) leaves and its constituents increase the activities of xenobiotic-metabolizing enzymes in mouse liver

Journal of Medicinal Food

Volumn 8, Issue 2, 2005, Pages 184-189

  Sasaki, Keiko ^a,b   Wada, Keiji ^b   Tanaka, Yoshiko ^b   Yoshimura, Teruki ^b   Matuoka, Koozi ^a   Anno, Takahiko ^c  

^a CHIBA INSTITUTE OF SCIENCE   (Japan)

^b HEALTH SCIENCES UNIVERSITY OF HOKKAIDO   (Japan)

^c NIPPON SHINYAKU CO LTD   (Japan)

Author keywords

7 ethoxycoumarin O deethylase; Carvacrol; Chemopreventive agents; Glutathione S transferase; Quinone reductase; Thyme; Thymol; Thymus vulgaris L. leaves; Xenobiotic metabolizing enzymes

Indexed keywords

7 ETHOXYCOUMARIN DEETHYLASE; CARVACROL; ENZYME INDUCING AGENT; GLUTATHIONE TRANSFERASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); THYMOL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DIET; ENZYME ACTIVITY; ENZYME INDUCTION; KIDNEY MASS; LIVER CYTOSOL; LIVER METABOLISM; LIVER MICROSOME; LIVER WEIGHT; MALE; MOUSE; NONHUMAN; PLANT LEAF; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; THYME; WESTERN BLOTTING; XENOBIOTIC METABOLISM;

7-ALKOXYCOUMARIN O-DEALKYLASE; ANIMALS; BLOTTING, WESTERN; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHORESIS, POLYACRYLAMIDE GEL; GLUTATHIONE TRANSFERASE; LIVER; MALE; MICE; MONOTERPENES; NAD(P)H DEHYDROGENASE (QUINONE); ORGAN SIZE; PLANT EXTRACTS; PLANT LEAVES; RANDOM ALLOCATION; THYMOL; THYMUS PLANT; XENOBIOTICS;

ANIMALIA; THYMUS VULGARIS;

EID: 22444438269     PISSN: 1096620X     EISSN: None     Source Type: Journal    
DOI: 10.1089/jmf.2005.8.184     Document Type: Article

References (33)

1. Barnes J, Anderson LA, Phillipson JD: Thyme. In: Herbal Medicines, 2nd ed., Pharmaceutical Press, London, 2002, pp. 462-464.
2. Lai PK, Roy J: Antimicrobial and chemopreventive properties of herbs and spices. Curr Med Chem 2004;11:1451-1460.
3. Aeschbach R, Loliger J, Scott BC, Murcia A, Butler J, Halliwell B, Aruoma OI: Antioxidant actions of thymol, carvacrol, 6-gingerol, zingerone and hydroxytyrosol. Food Chem Toxicol 1994;32:31-36.
4. Varel VH, Miller DN: Plant-derived oils reduce pathogens and gaseous emissions from stored cattle waste. Appl Environ Microbiol 2001;67:1366-1370.
5. He L, Mo H, Hadisusilo S, Qureshi AA, Elson CE: Isoprenoids suppress the growth of murine B16 melanomas in vitro and in vivo. J Nutr 1997;127:668-674.
6. Sharma RA, Ireson CR, Verschoyle RD, Hill KA, Williams ML, Leuratti C, Manson MM, Marnett LJ, Steward WP, Gescher A: Effects of dietary curcumin on glutathione S-transferase and malondialdehyde-DNA adducts in rat liver and colon mucosa: Relationship with drug levels. Clin Cancer Res 2001;7:1452-1458.
7. Steinkellner H, Rabot S, Freywald C, Nobis E, Scharf G, Chabicovsky M, Knasmuller S, Kassie F: Effects of cruciferous vegetables and their constituents on drug metabolizing enzymes involved in the bioactivation of DNA-reactive dietary carcinogens. Mutat Res 2001;480-481:285-297.
8. Thornalley PJ: Isothiocyanates: Mechanism of cancer chemopreventive action. Anticancer Drugs 2002;13:331-338.
9. Dingley KH, Ubick EA, Chiarappa-Zucca ML, Nowell S, Abel S, Ebeler SE, Mitchell AE, Burns SA, Steinberg FM, Clifford AJ: Effect of dietary constituents with chemopreventive potential on adduct formation of a low dose of the heterocyclic amines PhIP and IQ and phase II hepatic enzymes. Nutr Cancer 2003;46: 212-221.
10. Song LL, Kosmeder JWII, Lee SK, Gerhäuser C, Lantvit D, Moon RC, Moriarty RM, Pezzuto JM: Cancer chemopreventive activity mediated by 4′-bromoflavone, a potent inducer of phase II detoxification enzymes. Cancer Res 1999;59:578-585.
11. Debersac P, Vernevaut M-F, Amiot M-J, Suschetet M, Siess M-H: Effects of a water-soluble extract of rosemary and its purified component rosmarinic acid on xenobiotic-metabolizing enzymes in rat liver. Food Chem Toxicol 2001;39:109-117.
12. Suzuki R, Kohno H, Sugie S, Sasaki K, Yoshimura T, Wada K, Tanaka T: Preventive effects of extract of leaves of ginkgo (Ginkgo biloba) and its component bilobalide on azoxymethane-induced colonie aberrant crypt foci in rats. Cancer Lett 2004;210:159-169.
13. Habig WH, Pabst MJ, Jakoby WB: Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. J Biol Chem 1974;249:7130-7139.
14. Ernster L: DT diaphorase. Methods Enzymol 1967;10:309-317.
15. Matsubara T, Otsubo S, Yoshihara E, Touchi A: Biotransformation of coumarin derivatives. (2). Oxidative metabolism of 7-alkoxycoumarin by microsomal enzymes and a simple assay procedure for 7-alkoxycoumarin O-dealkylase. Jpn J Pharmacol 1983;33:41-56.
16. Shimada T, Inoue K, Suzuki Y, Kawai T, Azuma E, Nakajima T, Shindo M, Kurose K, Sugie A, Yamagishi Y, Fujii-Kuriyama Y, Hashimoto M: Arylhydrocarbon receptor-dependent induction of liver and lung cytochromes P450 1A1, 1A2, and 1B1 by polycyclic aromatic hydrocarbons and polychlorinated biphenyls in genetically engineered C57BL/6J mice. Carcinogenesis 2002;23: 1199-1207.
17. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ: Protein measurement with the Folin phenol reagent. J Biol Chem 1951;193: 265-275.
18. Sasaki K, Hatta S, Wada K, Ueda N, Yoshimura T, Endo T, Sakata M, Tanaka T, Haga M: Effects of extract of Ginkgo biloba leaves and its constituents on carcinogen-metabolizing enzyme activities and glutathione levels in mouse liver. Life Sci 2002;70:1657-1667.
19. Towbin H, Staehelin T, Gordon J: Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications. Proc Natl Acad Sci USA 1979;76:4350-4354.
20. Hayes JD, Pulford DJ: The glutathione S-transferase supergene family: Regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance. Crit Rev Biochem Mol Biol 1995;30:445-600.
21. 1-8,9-epoxide conjugating activities of two bacterially expressed alpha class glutathione S-transferase isozymes from mouse and rat. Biochem Biophys Res Commun 1992;188:597-603.
22. 1-8,9-epoxide. Biochem J 1992;285(Pt 1):173-180.
23. Stanley JS, Benson AM: The conjugation of 4-nitroquinoline 1-oxide, a potent carcinogen, by mammalian glutathione transferases. 4-Nitroquinoline 1-oxide conjugation by human, rat and mouse liver cytosols, extrahepatic organs of mice and purified mouse glutathione transferase isoenzymes. Biochem J 1988;256: 303-306.
24. Goon D, Saxena M, Awasthi YC, Ross D: Activity of mouse liver glutathione S-transferases toward trans,trans-muconaldehyde and trans-4-hydroxy-2-nonenal. Toxicol Appl Pharmacol 1993;119: 175-180.
25. Yang Y, Sharma R, Zimniak P, Awasthi YC: Role of a class glutathione S-transferases as antioxidant enzymes in rodent tissues. Toxicol Appl Pharmacol 2002;182:105-115.
26. Joseph P, Long DJ 2nd, Klein-Szanto AJ, Jaiswal AK: Role of NAD(P)H:quinone oxidoreductase 1 (DT diaphorase) in protection against quinone toxicity. Biochem Pharmacol 2000;60:207-214.
27. Ross D, Kepa JK, Winski SL, Beall HD, Anwar A, Siegel D: NAD(P)H:quinone oxidoreductase 1 (NQO1): Chemoprotection, bioactivation, gene regulation and genetic polymorphisms. Chem Biol Interact 2000;129:77-97.
28. Gao X, Dinkova-Kostova AT, Talalay P: Powerful and prolonged protection of human retinal pigment epithelial cells, keratinocytes, and mouse leukemia cells against oxidative damage: The indirect antioxidant effects of sulforaphane. Proc Natl Acad Sci USA 2001;98:15221-15226.
29. Hayes JD, Ellis EM, Neal GE, Harrison, DJ, Manson MM: Cellular response to cancer chemopreventive agents: Contribution of the antioxidant responsive element to the adaptive response to oxidative and chemical stress. Biochem Soc Symp 1999;64:141-168.
30. Henderson CJ, Sahraouei A, Wolf CR: Cytochrome P450s and chemoprevention. Biochem Soc Trans 2000;28:42-46.
31. Miao W, Hu L, Kandouz M, Batist G: Oltipraz is a bifunctional inducer activating both phase I and phase II drug-metabolizing enzymes via the xenobiotic responsive element. Mol Pharmacol 2003;64:346-354.
32. Manson MM, Ball HW, Barrett MC, Clark HL, Judah DJ, Williamson G, Neal GE: Mechanism of action of dietary chemoprotective agents in rat liver: Induction of phase I and II drug metabolizing enzymes and aflatoxin B, metabolism. Carcinogenesis 1997;18:1729-1738.
33. Stammati A, Bonsi P, Zucco F, Moezelaar R, Alakomi H-L, von Wright A: Toxicity of selected plant volatiles in microbial and mammalian short-term assays. Food Chem Toxicol 1999;37:813-823.