A highly sensitive LC-MS-MS assay for analysis of midazolam and its major metabolite in human plasma: Applications to drug metabolism

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 822, Issue 1-2, 2005, Pages 27-32

  Jabor, Valquiria A P ^a   Coelho, Eduardo B ^a   Dos Santos, Neife A G ^a   Bonato, Pierina S ^a   Lanchote, Vera L ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

CYP3A4; LC MS MS; Midazolam; Pharmacokinetics; Plasma

Indexed keywords

CONCENTRATION (PROCESS); DRUG PRODUCTS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLITES; POSITIVE IONS; SEPARATION;

ELECTROSPRAY INTERFACE; HUMAN PLASMA; LIQUID-LIQUID EXTRACTION; MIDAZOLAM (MDZ);

BIOASSAY;

1 HYDROXYMIDAZOLAM; DRUG METABOLITE; MIDAZOLAM; UNCLASSIFIED DRUG;

ACCURACY; ADULT; ANALYTIC METHOD; ANALYTICAL EQUIPMENT; AREA UNDER THE CURVE; ARTICLE; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DETERMINATION; DRUG METABOLISM; FEMALE; HUMAN; HUMAN EXPERIMENT; LINEAR SYSTEM; LIQUID CHROMATOGRAPHY; LIQUID LIQUID EXTRACTION; NORMAL HUMAN; POSITIVE ION ELECTROSPRAY; PRIORITY JOURNAL; QUALITATIVE ANALYSIS; QUALITY CONTROL; QUANTITATIVE ANALYSIS; SEPARATION TECHNIQUE; SINGLE DRUG DOSE; TANDEM MASS SPECTROMETRY; VALIDATION PROCESS;

ADULT; CHROMATOGRAPHY, LIQUID; FEMALE; HUMANS; MASS SPECTROMETRY; MIDAZOLAM; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY;

EID: 22244493261     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2005.05.011     Document Type: Article

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