Biozzi mice: Of mice and human neurological diseases

Journal of Neuroimmunology

Volumn 165, Issue 1-2, 2005, Pages 1-10

  Amor, Sandra ^a,b   Smith, Paul A ^a   'T Hart, Bert ^a,b   Baker, David ^c  

^a BIOMEDICAL PRIMATE RESEARCH CENTRE   (Netherlands)

^b ERASMUS MEDICAL CENTER   (Netherlands)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Biozzi mice; Experimental autoimmune encephalomyelitis; Multiple sclerosis; Therapies

Indexed keywords

ANTIBODY; BREQUINAR; CANNABINOID RECEPTOR AGONIST; CANNABINOID RECEPTOR ANTAGONIST; CASPASE INHIBITOR; COLECALCIFEROL; CYCLOPHOSPHAMIDE; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; DEXAMETHASONE; GAMMA INTERFERON; GAMMA INTERFERON ANTIBODY; INTERLEUKIN 12 ANTIBODY; INTERLEUKIN 4; MEVINOLIN; MITOXANTRONE; PENICILLAMINE; PHOSPHOLIPID DERIVATIVE; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA ANTIBODY;

ADJUVANT THERAPY; AEROBIC METABOLISM; ALLERGIC ENCEPHALOMYELITIS; ANTIBODY PRODUCTION; ANTIBODY RESPONSE; AUTOIMMUNE DISEASE; BACTERIAL INFECTION; BIOZZI MOUSE; BREEDING; CENTRAL NERVOUS SYSTEM; CHROMOSOME ANALYSIS; CHRONIC DISEASE; DEMYELINATION; DISEASE MODEL; DISEASE SEVERITY; EXPERIMENTAL MODEL; GENE EXPRESSION; GENETIC ANALYSIS; GENETIC REGULATION; HISTOCOMPATIBILITY COMPLEX; IMMUNIZATION; IMMUNOGLOBULIN BLOOD LEVEL; INFECTION RESISTANCE; INFECTION SENSITIVITY; MACROPHAGE FUNCTION; MORTALITY; MOUSE; MOUSE STRAIN; MURINE ENCEPHALOMYELITIS VIRUS; NERVE DEGENERATION; NEURITIS; NEUROLOGIC DISEASE; NEUROPATHOLOGY; NONHUMAN; PATHOGENESIS; PATHOLOGY; PRIORITY JOURNAL; RECURRENT DISEASE; REVIEW; SALMONELLA TYPHIMURIUM; SEMLIKI FOREST ALPHAVIRUS; T LYMPHOCYTE; UVEITIS;

ALPHAVIRUS INFECTIONS; ANIMALS; CARDIOVIRUS INFECTIONS; CHRONIC DISEASE; DISEASE MODELS, ANIMAL; HUMANS; MICE; MICE, BIOZZI; MULTIPLE SCLEROSIS; NERVOUS SYSTEM AUTOIMMUNE DISEASE, EXPERIMENTAL; SEMLIKI FOREST VIRUS;

EID: 22144479347     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2005.04.010     Document Type: Review

References (81)

1. S.J. Allen, D. Baker, J.K. O'Neill, A.N. Davison, and J.L. Turk Isolation and characterization of cells infiltrating the spinal cord during the course of chronic relapsing experimental allergic encephalomyelitis in the Biozzi AB/H mouse Cell. Immunol. 146 1993 335 350
2. S. Amor, D. Baker, N. Groome, and J.L. Turk Identification of a major encephalitogenic epitope proteolipid protein (residues 56-70) for the induction of experimental allergic encephalomyelitis in Biozzi AB/H and non-obese diabetic mice J. Immunol. 150 1993 5666 5672
3. S. Amor, N. Groome, C. Linington, M.M. Morris, K. Dornmair, M.V. Gardinier, J.M. Matthieu, and D. Baker Identification of epitopes of myelin oligodendrocyte glycoprotein for the induction of experimental allergic encephalomyelitis in SJL and AB/H mice J. Immunol. 153 1994 4349 4356
4. g7) mice share an amino acid motif J. Immunol. 156 1996 3000 3008
5. Baker, D. (2005). Genetics of autoimmune encephalomyelitis. "Experimental Models of Multiple Sclerosis", E. Lavi and C. Constantinescu (eds) Kuler Academic Publishers, In press.
6. D. Baker, J.K. O'Neill, S.E. Gschmeissner, C.E. Wilcox, C. Butter, and J.L. Turk Induction of chronic relapsing experimental allergic encephalomyelitis in Biozzi mice J. Neuroimmunol. 28 1990 261 270
7. D. Baker, J.K. O'Neill, and J.L. Turk Cytokines in the central nervous system during chronic relapsing experimental allergic encephalomyelitis in the mouse Cell. Immunol. 134 1991 505 510
8. D. Baker, J.K. O'Neill, S. Amor, M.A. Kamashta, and J.L. Turk Inhibition of chronic relapsing experimental allergic encephalomyelitis in the mouse by the alkyl-lysophospholipid ET-18-OCH3 Int. J. Immunopharmacol. 13 1991 385 392
9. D. Baker, J.K. O'Neill, A.N. Davison, and J.L. Turk Control of immune-mediated disease of the central nervous system requires the use of a neuroactive agent: elucidation by the action of mitoxantrone Clin. Exp. Immunol. 90 1992 124 128
10. D. Baker, D. Butler, B.J. Scallon, J.K. O'Neill, J.L. Turk, and M. Feldmann Control of established experimental allergic encephalomyelitis by inhibition of tumor necrosis factor (TNF) activity within the central nervous system using monoclonal antibodies and TNF receptor immunoglobulin fusion proteins Eur. J. Immunol. 24 1994 2040 2048
11. D. Baker, O.A. Rosenwasser, J.K. O'Neill, and J.L. Turk Genetic analysis of experimental allergic encephalomyelitis in mice J. Immunol. 155 1995 4046 4051
12. D. Baker, G. Pryce, J.L. Croxford, P. Brown, J.W. Huffman, R.G. Pertwee, and L. Layward Cannabinoids control spasticity and tremor in an animal model of multiple sclerosis Nature 404 2000 84 87
13. D. Baker, G. Pryce, J.L. Croxford, P. Brown, R.G. Pertwee, L. Layward, and V. Di Marzo Endocannabinoids control spasticity in a multiple sclerosis model FASEB J. 15 2001 300 302
14. G. Biozzi, C. Stiffel, D. Mouton, Y. Bouthillier, and C. Decreusefond Cytodynamics of the immune response in two lines of mice genetically selected for "high" and "low" antibody synthesis J. Exp. Med. 135 1972 1071 1094
15. G. Biozzi, D. Mouton, A.M. Heumann, Y. Bouthillier, C. Stiffel, and J.C. Mevel Genetic analysis of antibody responsiveness to sheep erythrocytes in crosses between lines of mice selected for high or low antibody synthesis Immunology 36 1979 427 438
16. C. Bjartmar, and B.D. Trapp Axonal and neuronal degeneration in multiple sclerosis: mechanisms and functional consequences Curr. Opin. Neurol. 14 3 2001 271 278 (Jun)
17. J.A. Black, S. Dib-Hajj, D. Baker, J. Newcombe, M.L. Cuzner, and S.G. Waxman Sensory neuron-specific sodium channel SNS is abnormally expressed in the brains of mice with experimental allergic encephalomyelitis and humans with multiple sclerosis Proc. Natl. Acad. Sci. U. S. A. 97 2000 11598 11602
18. F.R. Brennan, J.K. O'Neill, S.J. Allen, C. Butter, G. Nuki, and D. Baker CD44 antigen is involved in selective leukocyte extravasation during inflammatory central nervous system disease Immunology 98 1999 427 435
19. J.W. Brooks, G. Pryce, T. Bisogno, S.I. Jagger, D.J.R. Hankey, P. Brown, D. Bridges, C. Ledent, M. Bifulco, A.S. Rice, V. Di Marzo, and D. Baker Arvanil-induced inhibition of spasticity and persistent pain: Further evidence for additional therapeutic non-CB1 cannabinoid receptors Eur. J. Pharmacol. 439 2002 83 92
20. A.M. Brown, and D.E. McFarlin Relapsing experimental allergic encephalomyelitis in the SJL/J mouse Lab. Invest. 45 1981 278 284
21. C. Bolton, J.K. O'Neill, S.J. Allen, and D. Baker Regulation of chronic relapsing experimental allergic encephalomyelitis by endogenous and exogenous glucocorticoids Int. Arch. Allergy Immunol. 114 1997 74 80
22. C. Butter, D. Baker, J.K. O'Neill, and J.L. Turk Mononuclear cell traffic and plasma protein extravasation into the CNS during chronic relapsing experimental allergic encephalomyelitis in Biozzi AB/H mice J. Neurol. Sci. 104 1991 9 12
23. C. Butter, J.K. O'Neill, D. Baker, S.E. Gschmeissner, and J.L. Turk An immunoelectron microscopical study of the expression of class II MHC during chronic relapsing experimental allergic encephalomyelitis in Biozzi mice J. Neuroimmunol. 33 1991 37 42
24. R.J. Butterfield, J.D. Sudweeks, E.P. Blankenhorn, R. Korngold, J.C. Marini, J.A. Todd, R.J. Roper, and C. Teuscher New genetic loci that control susceptibility and symptoms of experimental allergic encephalomyelitis in inbred mice J. Immunol. 161 1998 1860 1867
25. R.J. Butterfield, E.P. Blankenhorn, R.J. Roper, J.F. Zachary, R.W. Doerge, and C. Teuscher Identification of genetic loci controlling the characteristics and severity of brain and spinal cord lesions in experimental allergic encephalomyelitis Am. J. Pathol. 157 2000 637 645
26. R.J. Clatch, R.W. Melvold, M.C. Dal Canto, S.D. Miller, and H.L. Lipton The Theiler's murine encephalomyelitis virus (TMEV) model for multiple sclerosis shows a strong influence of the murine equivalents of HLA-A, B, and C J. Neuroimmunol. 15 1987 121 135
27. M.J. Craner, A.C. Lo, J.A. Black, and S.G. Waxman Abnormal sodium channel distribution in optic nerve axons in a model of inflammatory demyelination Brain 126 2003 1552 1561
28. K.J. Colombani, M. Pla, D. Mouton, and L. Degos H-2 typing of mice genetically selected for high or low dose antibody production Immunogenetics 8 1979 237 243
29. J.L. Croxford, J.K. O'Neill, and D. Baker Polygenic control of experimental allergic encephalomyelitis in Biozzi ABH and BALB/c mice J. Neuroimmunol. 74 1997 205 211
30. J.L. Croxford, K. Triantaphyllopoulos, O.S. Podhacjcer, M. Feldmann, D. Baker, and Y. Chernajovsky Cytokine gene therapy in experimental allergic encephalomyelitis by injection of plasmid DNA-cationic lipid complex into the central nervous system J. Immunol. 160 1998 5181 5187
31. J.L. Croxford, J.K. O'Neill, R.R. Ali, K. Brown, A.P. Byrnes, M.A.J. Wood, M. Dallman, M. Feldmann, and D. Baker Local gene therapy with CTLA4-immunoglobulin fusion protein in experimental allergic Eur. J. Immunol. 12 1998 3904 3917
32. J.L. Croxford, Y. Chernajovsky, and D. Baker Central nervous system gene therapy for experimental allergic encephalomyelitis Recent Research Developments In Immunology vol. 1 1999 113 132 Part 1
33. M. De Franco, S. Massa, R.C. Vassao, M. Siqueira, and O.A. Sant'Anna Polygenic control of antibody production and correlation with vaccine induced resistance to rabies virus in high and low antibody responder mice Arch. Virol. 141 1996 1397 1406
34. M.E. Devey, P.J. Major, K.M. Bleasdale-Barr, G.P. Holland, M.C. Dal Canto, and P.Y. Paterson Experimental allergic encephalomyelitis (EAE) in mice selectively bred to produce high affinity (HA) or low affinity (LA) antibody responses Immunology 69 1990 519 524
35. H.M. Dockrell, J. Taverne, R. Lelchuk, P. Depledge, I.N. Brown, and J.H. Playfair Macrophage functions in Biozzi mice Immunology 55 1985 501 509
36. B. Descamps-Latscha, A.T. Nguyen, and D. Mouton Macrophage oxidative activation potential in normal and endotoxin-treated Biozzi high and low antibody responder mice Exp. Clin. Immunogenet. 5 1988 226 237
37. J.A. Encinas, L.S. Wicker, L.B. Peterson, A. Mukasa, C. Teuscher, R. Sobel, H.L. Weiner, C.E. Seidman, J.G. Seidman, and V.K. Kuchroo QTL influencing autoimmune diabetes and encephalomyelitis map to a 0.15-cM region containing Il2 Nat. Genet. 21 1999 158 160
38. S. Fairchild, D. Baker, and J.L. Turk Characterization of EAE susceptible, inbred Biozzi AB/H (H-2dq1) mice which express H-2Anod: analysis of the T cell receptor phenotype and the detection of a deletion ligand encoded by Mtv-7 Immunology 78 1993 1260 1265
39. R. Furlan, G. Martino, F. Galbiati, P.L. Poliani, S. Smiroldo, A. Bergami, G. Desina, G. Comi, R. Flavell, M.S. Su, and L. Adorini Caspase-1 regulates the inflammatory process leading to autoimmune demyelination J Immunol. 163 1999 2403 2409
40. R. Furlan, P.L. Poliani, P.C. Marconi, A. Bergami, F. Ruffini, L. Adorini, J.C. Glorioso, G. Comi, and G. Martino Central nervous system gene therapy with interleukin-4 inhibits progression of ongoing relapsing-remitting autoimmune encephalomyelitis in Biozzi AB/H mice Gene Ther. 8 2001 13 19
41. J. Greenwood, C.E. Walters, G. Pryce, N. Kanuga, E. Beraud, D. Baker, and P. Adamson Lovastatin inhibits brain endothelial cell Rho-mediated lymphocyte migration and attenuates experimental autoimmune encephalomyelitis FASEB J. 17 2003 905 907
42. R.J. Hall, J.E. Hollis-Moffatt, M.E. Merriman, R.A. Green, D. Baker, and T.R. Merriman An autoimmune diabetes locus (Idd21) on mouse chromosome 18 Mamm. Genome 14 2003 335 339
43. D.J. Hankey, J.M. Nickerson, L.A. Donoso, S.L. Lightman, and D. Baker Experimental autoimmune uveoretinitis in mice (Biozzi ABH and NOD) expressing the autoimmune-associated H-2A(g7) molecule: identification of a uveitogenic epitope J. Neuroimmunol. 118 2001 212 222
44. H. Heremans, C. Dillen, M. Groenen, E. Martens, and A. Billiau Chronic relapsing experimental autoimmune encephalomyelitis (CREAE) in mice: enhancement by monoclonal antibodies against interferon-gamma Eur. J. Immunol. 26 1996 2393 2398
45. H. Heremans, C. Dillen, M. Groenen, E. Martens, and A. Billiau Role of endogenous interleukin-12 (IL-12) in induced and spontaneous relapses of experimental autoimmune encephalomyelitis in mice Eur. Cytokine Netw. 10 1999 171 180
46. H.L. Lipton Persistent Theiler's murine encephalomyelitis virus infection in mice depends on plaque size J. Gen. Virol. 46 1980 169 177
47. H.L. Lipton, and R. Melvold Genetic analysis of susceptibility to Theiler's virus-induced demyelinating disease in mice J. Immunol. 132 1984 1821 1825
48. G. Lui, D. Baker, S. Fairchild, F. Figueroa, M. Quartey-Papafio Tone, D. Healey, A. Cooke, and D.C. Wraith Complete characterization of the expressed immune response genes in Biozzi AB/H mice: structural and functional identity between AB/H and NOD A-region molecules Immunogenetics 37 1993 296 300
49. F. Mattner, S. Smiroldo, F. Galbiati, M. Muller, P. Di Lucia, P.L. Poliani, G. Martino, P. Panina-Bordignon, and L. Adorini Inhibition of Th1 development and treatment of chronic-relapsing experimental allergic encephalomyelitis by a non-hypercalcemic analogue of 1,25-dihydroxyvitamin D(3) Eur. J. Immunol. 30 2000 498 508
50. T.R. Merriman, H.J. Cordell, I.A. Eaves, P.A. Danoy, F. Coraddu, R. Barber, F. Cucca, S. Broadley, S. Sawcer, A. Compston, P. Wordsworth, J. Shatford, S. Laval, J. Jirholt, R. Holmdahl, A.N. Theofilopoulos, D.H. Kono, J. Tuomilehto, E. Tuomilehto-Wolf, R. Buzzetti, M.G. Marrosu, D.E. Undlien, K.S. Ronningen, C. Ionesco-Tirgoviste, J.P. Shield, F. Pociot, J. Nerup, C.O. Jacob, C. Polychronakos, S.C. Bain, and J.A. Todd Suggestive evidence for association of human chromosome 18q12-q21 and its orthologue on rat and mouse chromosome 18 with several autoimmune diseases Diabetes 50 2001 184 194
51. R.Z. Ma, J. Gao, N.D. Meeker, P.D. Fillmore, K.S. Tung, T. Watanabe, J.F. Zachary, H. Offne, E.P. Blankenhorn, and C. Teuscher Identification of Bphs, an autoimmune disease locus, as histamine receptor H1 Science 297 2002 620 623
52. M.M. Morris, H. Dyson, D. Baker, L.S. Harbige, J.K. Fazakerley, and S. Amor Characterization of the cellular and cytokine response in the central nervous system following Semliki Forest virus infection J. Neuroimmunol. 74 1997 185 197
53. M.M. Morris-Downes, P.A. Smith, J.L. Rundle, S.J. Piddlesden, D. Baker, D. Pham-Dinh, N. Heijmans, and S. Amor Pathological and regulatory effects of anti-myelin antibodies in experimental allergic encephalomyelitis in mice J. Neuroimmunol. 125 2002 114 124
54. M.M. Morris-Downes, K. McCormack, D. Baker, D. Sivaprasad, J. Natkumarajah, and S. Amor Encephalitogenic and immunogenic potential of myelin-associated glycoprotein (MAG), oligodendrocyte-specific glycoprotein (OSP) and 2′,3′-cyclic nucleotide 3′-phosphodiesterase (CNPase) in ABH and SJL mice J. Neuroimmunol. 122 2002 20 33
55. K. Norga, L. Paemen, S. Masure, C. Dillen, H. Heremans, A. Billiau, H. Carton, L. Cuzner, T. Olsson, and J. Van Damme Prevention of acute autoimmune encephalomyelitis and abrogation of relapses in murine models of multiple sclerosis by the protease inhibitor d-penicillamine Inflamm. Res. 44 1995 529 534
56. J.K. O'Neill, C. Butter, D. Baker, S.E. Gschmeissner, G. Kraal, E.C. Butcher, and J.L. Turk Expression of vascular addressins and ICAM-1 by endothelial cells in the spinal cord during chronic relapsing experimental allergic encephalomyelitis in the Biozzi AB/H mouse Immunology 72 1991 520 525
57. J.K. O'Neil, D. Baker, and J.L. Turk Inhibition of chronic relapsing experimental allergic encephalomyelitis in the Biozzi ABH mouse J. Neuroimmunol. 41 1992 177 188
58. J.K. O'Neill, D. Baker, A.N. Davison, K.K. Maggon, B.D. Jaffee, and J.L. Turk Therapy of chronic relapsing experimental allergic encephalomyelitis and the role of the blood-brain barrier: elucidation by the action of brequinar sodium J. Neuroimmunol. 38 1992 53 62
59. J.K. O'Neill, D. Baker, A.N. Davison, S.J. Allen, C. Butter, and J.L. Turk Control of immune-mediated disease of the central nervous system with (CD4-specific) monoclonal antibodies J. Neuroimmunol. 45 1993 1 14
60. J.K. O'Neill, D. Baker, M.M. Morris, S.E. Gschmeissner, H.G. Jenkins, A.M. Butt, S.L. Kirvell, and S. Amor Optic neuritis in chronic relapsing experimental allergic encephalomyelitis in Biozzi ABH mice: demyelination and fast axonal transport changes in disease J. Neuroimmunol. 82 1998 210 218
61. A. Petzold, D. Baker, G. Pryce, G. Keir, E.J. Thompson, and G. Giovannoni Quantitation of neurodegeneration by measurement of brain specific proteins J. Neuroimmunol. 138 2003 45 48
62. G. Pryce, G. Giovannoni, and D. Baker Mifepristone or inhibition of 11b-hydroxylase activity potentiates the sedating effects of the CB1 agonist D(9)-tetrahydrocannabinol Neurosci. Lett. 34 2003 164 166
63. G. Pryce, Z. Ahmed, D.R.J. Hankey, S.L. Jackson, J.L. Croxford, J.M. Pocock, C. Ledent, A. Petzhold, A.J. Thompson, G. Giovannoni, M.L. Cuzner, and D. Baker Cannabinoids inhibit neurodegeneration in multiple sclerosis models Brain 126 2003 2191 2202
64. G. Pryce, S.M. Jackson, D.J. Hankey, G. Giovannoni, and D. Baker Cannabinoids are neuroprotective: dissociation of true neuroprotection from protection secondary to immunosuppression J. Neuroimmunol 154 2004 78
65. A. Puel, J.C. Mevel, Y. Bouthillier, N. Feingold, W.H. Fridman, and D. Mouton Toward genetic dissection of high and low antibody responsiveness in Biozzi mice Proc. Natl. Acad. Sci. U. S. A. 93 1996 14742 14746
66. O.A. Sant'Anna, D. Mouton, O.M. Ibanez, Y. Bouthillier, J.C. Mevel, M.H. Reis, and G. Biozzi Basal immunoglobulin serum concentration and isotype distribution in relation to the polygenic control of antibody responsiveness in mice Immunogenetics 22 1985 131 139
67. O.A. Sant'Anna, S. Massa, D. Mouton, Y. Bouthillier, J.C. Mevel, O.M. Ibanez, R. Vassao, M. de Franco, R. Bellinati, and M. Siqueira Salmonella typhimurium infection in high and low antibody responder mice: inverse correlation between antibody responsiveness and resistance to infection FEMS Microbiol. Immunol. 1 1989 465 471
68. E. Silber, and M.K. Sharief Axonal degeneration in the pathogenesis of multiple sclerosis J. Neurol. Sci. 170 1999 11 18
69. J.P. Smith, M. Morris-Downes, F.R. Brennan, G.J. Wallace, and S. Amor A role for alpha 4-integrin in the pathology following Semliki Forest virus infection J. Neuroimmunol. 106 2000 60 68
70. K.J. Smith, R. Kapoor, S.M. Hall, and M. Davies Electrically active axons degenerate when exposed to nitric oxide Ann. Neurol. 49 2001 470 476
71. Smith, P.A. Heijmans, N., Ouwerling, B., Breij, E.C., Evans, N., van Noort, J.M. Plomp, A.C., Delarasse, C., 't Hart, B., Pham-Dinh, D., Amor, S., (in press). Native myelin oligodendrocyte glycoprotein (MOG) promotes severe chronic neurological disease and demyelination in Biozzi ABH mice. EJI. 35, XX.
72. R.M. Smith, A. Morgan, and D.C. Wraith Anti-class II MHC antibodies prevent and treat EAE without APC depletion Immunology 83 1994 1 8
73. M. Sundvall, J. Jirholt, H.T. Yang, L. Jansson, A. Engstrom, U. Pettersson, and R. Holmdahl Identification of murine loci associated with susceptibility to chronic experimental autoimmune encephalomyelitis Nat. Genet. 10 1995 313 317
74. B.A. 't Hart, and S. Amor The use of animal models to investigate the pathogenesis of neuroinflammatory disorders of the central nervous system Curr. Opin. Neurol. 16 2003 375 383
75. B.A. 't Hart, S. Amor, and M. Jonker Evaluating the validity of animal models for research into therapies for immune-based disorders Drug Discov. Today 9 2004 517 524
76. N.M. Thoua, J.M. van Noort, D. Baker, A. Bose, A.C. van Sechel, M.J. van Stipdonk, P.J. Travers, and S. Amor Encephalitogenic and immunogenic potential of the stress protein alphaB-crystallin in Biozzi ABH (H-2A(g7)) mice J. Neuroimmunol. 104 2000 47 57
77. R.C. Vassao, C.A. Consales, O.A. Sant'Anna, and C.A. Pereira Antibody responsiveness during immunization and challenge of genetically modified antibody responder mice with murine hepatitis virus 3 Immunobiology 207 2003 275 283
78. J.M. van Noort, A.C. van Sechel, J.J. Bajramovic, M. el Ouagmiri, C.H. Polman, H. Lassmann, and R. Ravid The small heat-shock protein alpha B-crystallin as candidate autoantigen in multiple sclerosis Nature 375 1995 798 801
79. C.E. Walters, G. Pryce, D.J. Hankey, S.M. Sebti, A.D. Hamilton, D. Baker, J. Greenwood, and P. Adamson Inhibition of Rho GTPases with protein prenyltransferase inhibitors prevents leukocyte recruitment to the central nervous system and attenuates clinical signs of disease in an animal model of multiple sclerosis J. Immunol. 68 2002 4087 4094
80. C.M. Watson, A.N. Davison, D. Baker, J.K. O'Neill, and J.L. Turk Suppression of demyelination by mitoxantrone Int. J. Immunopharmacol. 13 1991 923 930
81. S. Zamvil, P. Nelson, J. Trotter, D. Mitchell, R. Knobler, R. Fritz, and L. Steinman T-cell clones specific for myelin basic protein induce chronic relapsing paralysis and demyelination Nature 317 1985 355 358