Hippocampal mitochondrial dysfunction with decreased mtNOS activity in prehepatic portal hypertensive rats

Neurochemistry International

Volumn 47, Issue 5, 2005, Pages 362-368

  Lores Arnaiz, Silvia ^a   Perazzo, Juan Carlos ^a   Prestifilippo, Juan Pablo ^a   Lago, Néstor ^a   D'Amico, Gabriela ^a   Czerniczyniec, Analía ^a   Bustamante, Juanita ^a   Boveris, Alberto ^a   Lemberg, Abraham ^a  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

Author keywords

Hippocampus; Mitochondrial dysfunction; mtNOS; Portal hypertension

Indexed keywords

AMMONIA; NITRIC OXIDE SYNTHASE; SUCCINIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTROCYTE; BREATHING RATE; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVITY; HIPPOCAMPUS; MALE; MEMBRANE RUPTURE; MITOCHONDRION; NONHUMAN; OUTER MEMBRANE; PRIORITY JOURNAL; RAT; RENOVASCULAR HYPERTENSION; RESPIRATION CONTROL; ULTRASTRUCTURE;

ANIMALS; BLOOD PRESSURE; BLOTTING, WESTERN; HIPPOCAMPUS; HYPERTENSION, PORTAL; MALE; MICROSCOPY, ELECTRON; MITOCHONDRIA; NERVE TISSUE PROTEINS; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE I; OXYGEN CONSUMPTION; QUATERNARY AMMONIUM COMPOUNDS; RATS; RATS, WISTAR;

EID: 22044452420     PISSN: 01970186     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuint.2005.05.006     Document Type: Article

References (33)

1. J.P. Bolaños, S. Peuchen, S.J.R. Heales, J.M. Land, and J.B. Clark Nitric oxide-mediated inhibition of the mitochondrial respiratory chain in cultured astrocytes J. Neurochem. 63 1994 910 916
2. A. Boveris, L.E. Costa, E. Cadenas, and J.J. Poderoso Regulation of mitochondrial respiration by adenosine diphosphate, oxygen and nitric oxide Meth. Enzymol. 301 1999 188 198
3. A. Boveris, S. Lores Arnaiz, J. Bustamante, S. Alvarez, L. Valdez, A.D. Boveris, and A. Navarro Pharmacological regulation of mitochondrial nitric oxide synthase Meth. Enzymol. 359 2002 328 339
4. A. Boveris, G. D'Amico, S. Lores-Arnaiz, and L.E. Costa Enalapril increases mitochondrial nitric oxide synthase activity in heart and liver Antioxidants Redox Signal. 5 2003 691 697
5. R.F. Butterworth The neurobiology of hepatic encephalopathy Seminars Liver Dis. 16 1996 235 244
6. R.F. Butterworth Pathogenesis of hepatic encephalopathy: new insights from neuroimaging and molecular studies J. Hepatol. 39 2003 278 285
7. J.B. Clark, and W.J. Nicklas The metabolism of rat brain mitochondria. Preparation and characterization J. Biol. Chem. 245 1970 4724 4731
8. E.M. de Cavanagh, B. Piotrkowski, N. Basso, I. Stella, F. Inserra, L. Ferder, and C.G. Fraga Enalapril and losartan attenuate mitochondrial dysfunction in aged rats FASEB J. 17 2003 1096 1098
9. V. Felipo, and R.F. Butterworth Mitochondrial dysfunction in acute hyperammonemia Neurochem. Int. 40 2002 487 491
10. P. Ghafourifar, and C. Richter Nitric oxide synthase activity in mitochondria FEBS Lett. 418 1997 291 296
11. C. Giulivi, J.J. Poderoso, and A. Boveris Production of nitric oxide by mitochondria J. Biol. Chem. 273 1998 11038 11043
12. L. Hertz, A.C.H. Yu, G. Kala, and A. Schousbol Neuronal-astrocytic and cytosolic-mitochondrial metabolite trafficking during brain activation, hyperammonemia and energy deprivation Neurochem. Int. 37 2000 83 102
13. K. Kikuchi, T. Nagano, and M. Hirobe Novel detection method of nitric oxide using horseradish peroxidase Biol. Pharm. Bull. 19 1996 649 665
14. E. Kosenko, A. Kaminsky, O. Lopata, N. Muravyov, C. Hermenegildo, and V. Felipo Nitroarginine, an inhibitor of nitric oxide synthase, prevents changes in superoxide radical and antioxidant enzymes induced by ammonia intoxication Metab. Brain Dis. 13 1998 29 41
15. Z. Lacza, M. Puskar, J.P. Figueroa, J. Zhang, N. Rajapakse, and D.W. Busua Mitochondrial nitric oxide synthase is constitutively active and is functionally upregulated in hypoxia Free Rad. Biol. Med. 31 2001 1609 1615
16. A. Lemberg, F.X. Eizayaga, M. Vatta, A. Dominguez, S. Romay, L.G. Bianciotti, G. Sansó, and B. Fernandez Prehepatic portal hypertension in rats modifies norhepinephrine metabolism in the hypothalamus, medula oblongata and portal vein Digestive Dis. Sci. 38 1993 1259 1262
17. A. Lemberg, J. Perazzo, S. Romay, F.X. Eizayaga, M. Vatta, M.R. Rodriguez-Fermepin, L. Bianciotti, A. Monserrat, and B. Fernandez Norhepinephrine uptake is enhanced in discrete telencephalic and diencephalic areas and nuclei in prehepatic portal hypertensive rats Brain Res. Bull. 45 1998 153 156
18. A.H. Loockwood, H. Weissenborn, and R.F. Butterworth An image of the brain in patients with liver disease Curr. Opin. Neurol. 10 1997 525 533
19. S. Lores Arnaiz, M.F. Coronel, and A. Boveris Nitric oxide, superoxide and hydrogen peroxide production in brain mitochondria after haloperidol treatment Nitric Oxide: Biol. Chem. 3 1999 235 243
20. S. Lores Arnaiz, G. ĎAmico, N. Paglia, M. Arismendi, N. Basso, and M.R. Lores Arnaiz Enriched environment, nitric oxide production and synaptic plasticity prevent the aging-dependent impairment of spatial cognition Mol. Aspects Med. 25 2004 91 101
21. S. Lores Arnaiz, G. ĎAmico, A. Czerniczyniec, J. Bustamante, and A. Boveris Brain mitochondrial nitric oxide synthase: in vitro and in vivo inhibition by chlorpromazine Arch. Biochem. Biophys. 430 2004 170 177
22. A. Navarro Mitochondrial enzyme activities as biochemical markers of aging Mol. Aspects Med. 25 2004 37 48
23. A. Navarro, and A. Boveris Rat brain and liver mitochondria develop oxidative stress and lose enzymatic activities upon aging Am. J. Physiol. Regul. Integr. Comp. Physiol. 287 2004 R1244 R1249
24. E. Nisoli, E. Clemente, C. Paolucci, V. Cozzi, C. Tonello, C. Sciorati, R. Bracale, A. Valerio, N. Francolín, S. Moncada, and M.O. Carruba Mitochondrial biogenesis in mammals: the role of endogenous nitric oxide Science 299 2003 896 899
25. M.D. Noremberg Astrocytic-ammonia interaction in hepatic encephalopathy Seminars Liver Dis. 16 1996 245 253
26. G. Paxinos, and C. Watson The Rat Brain in Stereotaxic Coordinates 4th ed 2002 Academic Press New York, USA
27. J. Perazzo, O. Canessa, M. Ferrini, M.A. Franchino, L. Bengochea, C. Ghanem, and A. Lemberg Alteraciones morfológicas de astrocitos en cerebros de ratas hipertensas portales Medicina 58 1998 582 (Abst.)
28. V.L. Rao, R.M. Andet, and R.F. Butterworth Increased nitric oxide synthetase activities and l-[3H]-arginine uptake in brain following portocaval anastomosis J. Neurochem. 65 1995 677 681
29. P.V. Reddy, Ch.R. Murthy, and P. Reddanna Fulminat hepatic failure induced oxidative stress in nonsynaptic mitochondria of cerebral cortex in rats Neurosci. Lett. 368 2004 15 20
30. N.A. Riobó, M. Melani, N. Sanjuan, M.L. Fiszman, M.C. Gravielle, M.C. Carreras, E. Cadenas, and J.J. Poderoso The modulation of mitochondrial nitric-oxide synthase activity in rat brain development J. Biol. Chem. 277 2002 42447 42455
31. C. Scorticati, J.P. Prestifilippo, F.X. Eizayaga, J.C. Castro, S. Romay, M.A. Fernández, A. Lemberg, and J.C. Perazzo Hyperammonemia, brain edema and blood-brain barrier alterations in prehepatic portal hypertensive rats and paracetamol intoxication World J. Gastroenterol. 10 9 2004 1321 1324
32. J. Vorobioff, J.E. Bredfelt, and R.J. Groszmann Hyperdynamic circulation in portal hypertensive rat model: a primary factor for maintenance of chronic portal hypertension Am. J. Physiol. 244 1983 G52 G57
33. T. Zaobornyj, L.B. Valdez, P. La Padula, L.E. Costa, and A. Boveris Effect of sustained hypobaric hypoxia during maturation and aging on rat myocardium. II. mtNOS activity J. Appl. Physiol. 98 2005 2370 2375