Ischemic neuroprotection with selective κ-opioid receptor agonist is gender specific

Stroke

Volumn 36, Issue 7, 2005, Pages 1557-1561

  Chen, Chih Hung ^a,b   Toung, Thomas J K ^a   Hum, Patricia D ^c   Koehler, Raymond C ^a   Bhardwaj, Anish ^a,d  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^c OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^d JOHNS HOPKINS HOSPITAL   (United States)

Author keywords

Cerebral ischemia, focal; Gender; Neuroprotection; Receptors, opioid; Reperfusion

Indexed keywords

1 (3,4 DICHLOROPHENYL)ACETYL 2 (1 PYRROLIDINYL)METHYLPIPERIDINE; BRL 52537; KAPPA OPIATE RECEPTOR AGONIST; NEUROPROTECTIVE AGENT; NITRIC OXIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN INFARCTION SIZE; BRAIN INJURY; BRAIN ISCHEMIA; CONTROLLED STUDY; DRUG POTENCY; DRUG SELECTIVITY; FEMALE; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROPHARMACOLOGY; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT; REPERFUSION; SEX DIFFERENCE; TREATMENT OUTCOME;

ANIMALS; BLOOD PRESSURE; BRAIN ISCHEMIA; CAUDATE NUCLEUS; CEREBRAL CORTEX; FEMALE; HORMONES; INFARCTION, MIDDLE CEREBRAL ARTERY; ISCHEMIA; LASER-DOPPLER FLOWMETRY; MALE; NEUROPROTECTIVE AGENTS; NITRIC OXIDE; OVARY; PARTIAL PRESSURE; PIPERIDINES; PUTAMEN; PYRROLIDINES; RATS; RATS, WISTAR; RECEPTORS, OPIOID, KAPPA; REPERFUSION; REPERFUSION INJURY; SEX FACTORS;

EID: 22044442374     PISSN: 00392499     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.STR.0000169928.76321.3d     Document Type: Article

References (28)

1. Mackay KB, Patel TR, Galbraith SL, Woodruff GN, McCulloch J. Effect of kappa-1 opioid agonist CI-977 on ischemic brain damage and cerebral blood flow after middle cerebral artery occlusion in the rat. Brain Res. 1993;629:10-18.
2. Birch PJ, Rogers H, Hayes AG, Hayward NJ, Tyers MB, Scopes DIC, Naylor A, Judd DB. Neuroprotective actions of GR89696, a highly potent and selective κ-opioid receptor agonist. Br J Pharmacol. 1991;103: 1819-1823.
3. Baskin DS, Widmayer MA, Browning JL, Heizer ML, Schnidt WK. Evaluation of delayed treatment of focal cerebral ischemia with three selective κ-opioid agonists in cats. Stroke. 1994;25:2047-2054.
4. Itoh J, Ukai M, Kameyama T. U-50,488H, a κ-receptor agonist, markedly prevents memory dysfunctions induced by transient cerebral ischemia in mice. Brain Res. 1993;619:223-228.
5. Genovese RF, Moreton JE, Tortella FC. Evaluation of neuroprotection and behavioral recovery by the kappa-opioid, PD117302 following transient forebrain ischemia. Brain Res Bull. 1994;34:111-116.
6. Goyagi T, Toung TJK, Kirsch JR, Traystman, Koehler RC, Hum PD, Bhardwaj A. Neuroprotective kappa opioid receptor agonist, BRL 52537 attenuates ischemia-evoked nitric oxide production in vivo in rats. Stroke. 2003;34:1533-1538.
7. Zhang Z, Chen TY, Kirsch JR, Toung TJ, Traystman RJ, Koehler RC, Hurn PD, Bhardwaj A. Kappa-opioid receptor selectivity for ischemic neuroprotection with BRL 52537 in rats. Anesth Analg. 2003;97: 1776-1783.
8. Chen TY, Goyagi T, Toung TJ, Kirsch JR, Hum PD, Koehler RC, Bhardwaj A. Prolonged opportunity for ischemic neuroprotection with selective kappa-opioid receptor agonist in rats. Stroke. 2004;35: 1180-1185.
9. You ZB, Herrera-Marschitz M, Terenius L. Modulation of neurotransmitter release in the basal ganglia of the rat brain by dynorphin peptides. J Pharmacol Exp Ther. 1999;290:1307-1315.
10. Shippenberg TS, Chefer VI, Zapata A, Heibreder CA. Modulation of the behavioral and neurochemical effects of psychostimulants by kappa-opioid receptor systems. Ann N Y Acad Sci. 2001;937:50-73.
11. Schoffelmeer N, Hogenboom F, Mulder AH. Kappa 1- and kappa 2-opioid receptors mediating presynaptic inhibition of dopamine and acetylcholine release in rat neostriatum. Br J Pharmacol. 1997;122; 520-524.
12. Hum PD, Brass LM. Estrogen and stroke: a balanced analysis. Stroke. 2003;265:1883-1885.
13. Alkayed NJ, Harukuni I, Kimes AS, London ED, Traystman RJ, Hum PD. Gender-linked brain injury in experimental stroke. Stroke. 1998;29: 159-165.
14. Alkayed NJ, Murphy SJ, Traystman RJ, Hum PD, Miller VM. Neuroprotective effects of female gonadal steroids in reproductively senescent female rats. Stroke. 2000;31:161-168.
15. Hurn PD, Macrae IM. Estrogen as a neuroprotectant in stroke. J Cereb Blood Flow Metab. 2000;20:631-652.
16. McCullough LD, Hurn PD. Estrogen and ischemic neuroprotection: an integrated view. Trends Endocrinol Metab. 2003;14:228-235.
17. Sampei K, Mandir AS, Asano Y, Wong PC, Traystman RJ, Dawson VL, Dawson TM, Hurn PD. Stroke outcome in double-mutant antioxidant transgenic mice. Stroke. 2000;31:2685-2691.
18. Vecchietti V, Giordani A, Giardina G, Colle R, Clarke GD. (2S)-1-(arylacetyl)-2-(aminomethyl) piperidine derivatives: novel, highly selective kappa opioid analgesics. J Med Chem. 1991;34:397-403.
19. Vecchietti V, Clarke GD, Colle R, Dondio G, Giardina G, Petrone G, Sbacchi M. Substituted 1-(aminomethyl)-2-(arylacetyl)-1,2,3,4- tetrahydroisoquinolines: a novel class of very potent antinociceptive agents with varying degrees for kappa and mu opioid receptors. J Med Chem. 1992;35:2970-2978.
20. Longa EZ, Weinstein PR, Carlson S, Cummings R. Reversible middle cerebral artery occlusion without craniotomy in rats. Stroke. 1989;20: 84-91.
21. Bederson JB, Pitts LH, Tsuji M, Nishimura MC, Davis RL, Bartowski H. Rat middle cerebral artery occlusion: evaluation of the model and development of a neurological exam. Stroke. 1986;17:472-476.
22. Werner C, Hoffman WE, Kochs E, Rabito SF, Miletich DJ. Captopril improves neurologic outcome from incomplete cerebral ischemia in rats. Stroke. 1991;22:910-914.
23. Hjelmstad GO, Fields HL. Kappa opioid receptor activation in the nucleus accumbens inhibits glutamate and GABA through different mechanisms. J Neurophysiol. 2003;89:2389-2395.
24. Murphy SJ, Littleton-Kearney MT, Hurn PD. Progesterone administration during reperfusion but not pre-ischemia alone reduces injury in ovariectomized rat. J Cereb Blood Flow Metab. 2002;22:1181-1188.
25. Tershner SA, Michell JM, Fields HL. Brainstem pain modulating circuitry is sexually dimorphic with respect to mu and kappa opioid receptor function. Pain. 2000;85:153-159.
26. Du L, Bayir H, Lai Y, Zhang X, Kochanek PM, Watkins SC, Graham SH, Clark RS. Innate gender-based proclivity in response to cytotoxicity and programmed cell death pathway. J Biol Chem. 2004;279:38563-38570.
27. McCullough LD, Zeng Z, Blizzard KK, Debchoudhury I, Hurn PD. Ischemic nitric oxide and poly (ADP-ribose) polymerase-1 in cerebral ischemia: male toxicity, female protection. J Cereb Blood Flow Metab. 2005;25:502-512.
28. Hagberg H, Wilson MA, Matsushita H, Zhu C, Lange M, Gustavsson M, Poitras MF, Dawson TM, Dawson VL, Northington F, Johnston MV. PARP-1 gene disruption in mice preferentially protects males from perinatal brain injury. J Neurochem. 2004;90:1068-1075.