Effects of 5-HT2 and 5-HT3 receptors on the modulation of nociceptive transmission in rat spinal cord according to the formalin test

European Journal of Pharmacology

Volumn 424, Issue 1, 2001, Pages 45-52

  Sasaki, Masayuki ^a   Ishizaki, Keiji ^a   Obata, Hideaki ^a   Goto, Fumio ^a  

^a GUNMA UNIVERSITY   (Japan)

Author keywords

(Rat); 5 HT (5 hydroxytryptamine, serotonin); 5 HT receptor subtype; Antinociception; Formalin test; Spinal cord

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; 2 METHYLSEROTONIN; 3 (1,2,5,6 TETRAHYDRO 4 PYRIDYL)PYRROLO[3,2 B]PYRIDIN 5 ONE; 4 IODO 2,5 DIMETHOXYAMPHETAMINE; BEMESETRON; KETANSERIN; RECEPTOR SUBTYPE; SEROTONIN 2 RECEPTOR; SEROTONIN 3 RECEPTOR; 2 METHYL 5 HT; 2-METHYL-5-HT; 3 (1,2,5,6 TETRAHYDROPYRID 4 YL)PYRROLO(3,2 B)PYRID 5 ONE; 3-(1,2,5,6-TETRAHYDROPYRID-4-YL)PYRROLO(3,2-B)PYRID-5-ONE; 4-IODO-2,5-DIMETHOXYPHENYLISOPROPYLAMINE; AMPHETAMINE DERIVATIVE; DRUG DERIVATIVE; FORMALDEHYDE; PYRIDINE DERIVATIVE; PYRROLE DERIVATIVE; SEROTONIN; SEROTONIN 1 RECEPTOR; SEROTONIN 1B RECEPTOR; SEROTONIN AGONIST; SEROTONIN ANTAGONIST; SEROTONIN RECEPTOR; TROPANE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DOSE TIME EFFECT RELATION; DRUG ANTAGONISM; DRUG EFFECT; MALE; MODULATION; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; RAT; SPINAL CORD; STIMULATION; ANIMAL; CHEMICALLY INDUCED DISORDER; INTRASPINAL DRUG ADMINISTRATION; NOCICEPTIVE RECEPTOR; PAIN; PAIN ASSESSMENT; PATHOPHYSIOLOGY; PHYSIOLOGY; SYNAPTIC TRANSMISSION; WISTAR RAT;

8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN; AMPHETAMINES; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; FORMALDEHYDE; INJECTIONS, SPINAL; MALE; NOCICEPTORS; PAIN; PAIN MEASUREMENT; PYRIDINES; PYRROLES; RATS; RATS, WISTAR; RECEPTOR, SEROTONIN, 5-HT1B; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT1; RECEPTORS, SEROTONIN, 5-HT3; SEROTONIN; SEROTONIN AGONISTS; SEROTONIN ANTAGONISTS; SPINAL CORD; SYNAPTIC TRANSMISSION; TROPANES;

EID: 0035854282     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(01)01117-7     Document Type: Article

References (60)

1. Phencyclidine selectively blocks a spinal action of N-methyl-d-aspartate in mice
2. 2 receptor regulation of extracellular GABA levels in the prefrontal cortex
3. 1B receptor subtypes in modulating spinal nociceptive transmission in mice
4. 3 receptor-mediated antinociception: Possible release of GABA
5. Effect of intrathecal serotonin on nociception in rats: Influence of the pain test used
6. 3 receptor antagonists on spinal serotonin-induced analgesia in rats
7. Serotonine receptor subtypes involved in the spinal antinociceptive effect of 5-HT in rats
8. The differential effects of 5-hydroxytryptamine, noradrenaline and raphe stimulation on nociceptive and non-nociceptive dorsal horn interneurones in the cat
9. Central nervous system plasticity in the tonic pain response to subcutaneous injection
10. Comparison of the effects of substance P, neurokinin A, physalaemin and eledoisin in facilitating a nociceptive reflex in the rat
11. Analgesic effects of serotonin and receptor-selective serotonin agonist in the rat spinal cord
12. 3 receptor subtypes modulate responses to noxious colorectal distension in the rat
13. 5-Hydroxytryptamine reduces substance P responses on dorsal horn interneurons: A possible interaction of neurotransmitters
14. Differential effects of excitatory amino acid antagonists on dorsal horn nociceptive neurones in the rat
15. The formalin test: A quantitative study of the analgesic effects of morphine, meperidine, and brain stem stimulation in rats and cats
16. 2 receptors in spinal cord in the control of nociceptive responsiveness
17. 1B receptors in the modulation of a spinal nociceptive reflex
18. Mechanises of 5-hydroxytryptamine-induced vasoconstriction
19. Neuronal 5-HT receptors in the periphery
20. Analgesic profile of centrally administered 2-methylserotonin against acute pain in rats
21. 3 binding sites in rat spinal cord synaptosomal membranes
22. 3 receptors modulate spinal nociceptive reflexes
23. Evidence for spinal N-methyl-d-asparate receptor involvement in prolonged chemical nociception in the rat
24. 1B receptor binding sites?
25. 3 receptor binding sites are on capsaicin-sensitive fibres in the rat spinal cord
26. Serotonin receptors and the modulation of pain
27. Behavioural effects of intraplantar injection of inflammatory mediators in the rat
28. International union of pharmacology classification of receptors for 5-hydroxytryptamine (serotonin)
29. Formalin test in mice, a useful technique for evaluating mild analgesics
30. Loss of gaba-immunoreactivity in the spinal dorsal horn of rats with peripheral nerve injury and promotion of recovery by adrenal medullary grafts
31. Serotonin type-2 receptor mediated regulation of substance P release in the ventral spinal cord and the effects of chronic antidepressant tretment
32. 3 receptors in the rat central nervous system are mainly located on nerve fibers and terminals
33. 1B) agonist and rotationally restricted phenolic analogue of 5-methoxy-3-(1, 2, 5, 6-tetrahydropyrid-4-yl) indole
34. Antinociceptive effect of alfa-trinositol, a novel D-myo-inositol phosphate derivative, in the formalin test in rats
35. 2 receptors in the rat spinal cord
36. Analgesia from electrical stimulation in the brainstem of the rat
37. Peripheral nerve injury triggers noradrenergic sprouting within dorsal root ganglia
38. Physiological properties of unmyelinated fiber protection to the spinal cord
39. 1A receptors does not elicit antinociception against noxious thermal, mechanical and chemical stimuli in mice
40. 1B receptors in spinal nociceptive transmission and in the modulation of NMDA induced behaviour
41. 2 agonists in rats with nerve ligation
42. Quantitative autoradiographic mapping of serotonin receptors in the rat brain: I. Serotonin-1 receptors
43. Quantitative autoradiographic mapping of serotonin receptors in the rat brain: II. Serotonin-2 receptors
44. 3H] spiroperidol
45. Formalin-evoked activity in identified primary afferent fibers: Systemic lidocaine suppresses phase-2 activity
46. Pharmacological antagonism of the antinociceptive effects of serotonin in the rat spinal cord
47. 1B receptor ligands exist?
48. Mechanisms of effects of intrathecal serotonin on nociception and blood pressure in rats
49. Transsynaptic degeneration in the surperficial dorsal horn after sciatic nerve injury: Effects of a chronic constriction injury, transection, and strychnine
50. 2 receptors potentates the spontaneous inhibitory postsynaptic currents on (sIPSCs) in trigeminal neurons
51. 1C/2 binding sites in the rat spinal cord
52. The rat paw formalin test: Comparison of noxious agents
53. Nociceptive and antinociceptive action of serotonergic agonists administered intrathecally
54. Peripheral nerve injury triggers central sprouting of myelinated afferents
55. Serotonin receptor subtypes in spinal antinociception in the rat
56. Chronic catheterization of the spinal subarachnoid space
57. Spinal serotonin terminal system mediates antinociception
58. Comparison of the antinociceptive effects of pre- and post-treatment with intrathecal morphine and MK 801, an NMDA antagonist, on the formalin test in the rat
59. 1 receptor subtypes
60. Noradrenergic and serotonergic mediation of spinal analgesia mechanisms