Effects of gabapentin on spontaneous discharges and subthreshold membrane potential oscillation of type a neurons in injured DRG

Pain

Volumn 116, Issue 3, 2005, Pages 187-193

  Yang, Rui Hua ^a   Xing, Jun Ling ^a   Duan, Jian Hong ^a   Hu, San Jue ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Dorsal root ganglion; Gabapentin; Neuropathic pain; Spontaneous discharge; Subthreshold membrane potential oscillation

Indexed keywords

GABAPENTIN;

AFFERENT NERVE GROUP 1; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; COMPRESSION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ELECTROPHYSIOLOGY; ELECTROSTIMULATION; FEMALE; MALE; MEMBRANE POTENTIAL; NERVE CELL; NERVE CELL LESION; NERVE CONDUCTION; NERVE STIMULATION; NEUROPATHIC PAIN; NONHUMAN; OSCILLATION; PRIORITY JOURNAL; RAT; SPINAL CORD; SPINAL GANGLION;

AMINES; ANALGESICS; ANIMALS; ANIMALS, NEWBORN; CYCLOHEXANECARBOXYLIC ACIDS; DIFFERENTIAL THRESHOLD; DOSE-RESPONSE RELATIONSHIP, DRUG; DOSE-RESPONSE RELATIONSHIP, RADIATION; ELECTRIC STIMULATION; FEMALE; GAMMA-AMINOBUTYRIC ACID; GANGLIA, SPINAL; MALE; MEMBRANE POTENTIALS; NERVE CRUSH; NERVE FIBERS; NEURAL INHIBITION; NEURONS; PERIPHERAL NERVOUS SYSTEM DISEASES; RATS; RATS, SPRAGUE-DAWLEY; TIME FACTORS;

EID: 21844464084     PISSN: 03043959     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pain.2005.04.001     Document Type: Article

References (46)

1. N. Agrawal, B.N. Hamam, J. Magistretti, A. Alonso, and D.S. Ragsdale Persistent sodium channel activity mediates subthreshold membrane potential oscillations and low-threshold spikes in rat entorhinal cortex layer V neurons Neuroscience 102 1 2001 53 64
2. K.J. Alden, and J. Garcia Differential effect of gabapentin on neuronal and muscle calcium currents J Pharmacol Exp Ther 297 2 2001 727 735
3. R. Amir, M. Michaelis, and M. Devor Membrane potential oscillations in dorsal root ganglion neurons: role in normal electrogenesis and neuropathic pain J Neurosci 19 19 1999 8589 8596
4. R. Amir, C.N. Liu, J.D. Kocsis, and M. Devor Oscillatory mechanism in primary sensory neurons Brain 125 2 2002 421 435
5. M. Backonja Anticonvulsants (antineuropathics) for neuropathic pain syndromes Clin J Pain 16 2000 S67 S72
6. D.J. Berry, R.G. Beran, M.J. Plunkeft, L.A. Clarke, and W.T. Hung The absorption of gabapentin following high dose escalation Seizure 12 2003 28 36
7. S.M. Carlton, and S. Zhou Attenuation of formalin-induced nociceptive behaviors following local peripheral injection of gabapentin Pain 76 1998 201 207
8. V. Chapman, R. Suzuki, H.L. Chamarette, L.J. Rygh, and A.H. Dickenson Effects of systemic carbamazepine and gabapentin on spinal neuronal responses in spinal nerve ligated rats Pain 75 1998 261 272
9. H.S. Cho, M.H. Kim, D.H. Choi, J. Lee, M.S. Gwak, and T.S. Hahm The effect of intrathecal gabapentin on mechanical and thermal hyperalgelsia in neuropathic rats induced by spinal nerve ligation J Korean Med Sci 17 2002 225 229
10. M. Devor, and Z. Seltzer Pathophysiology of damaged nerves in relation to chronic pain P.D. Wall R. Melzack Textbook of pain 4th ed 1999 Churchill Livingston London 129 164
11. M. Devor, P.D. Wall, and N. Catalan Systemic lidocaine silences ectopic neuroma and DRG discharge without blocking nerve conduction Pain 48 1992 261 268
12. M.J. Field, E.F. Holloman, S. McCleary, J. Hughes, and L. Singh Evaluation of gabapentin and S-(1)-3-isobutylgaba in a rat model of postoperative pain J Pharmacol Exp Ther 282 1997 1242 1246
13. A. Fox, C. Gentry, S. Patel, A. Kesingland, and S. Bevan Comparative activity of the anti-convulsants oxcarbazepine, carbamazepine, lamotrigine and gabapentin in a model of neuropathic pain in the rat and guinea-pig Pain 105 2003 355 362
14. N.S. Gee, J.P. Brown, V.U. Dissanayake, J. Offord, R. Thurlow, and G.N. Woodruff The novel anticonvulsant drug, gabapentin (Neurontin), binds to the alpha2delta subunit of a calcium channel J Biol Chem 271 1996 5768 5776
15. S. Gillin, and L.S. Sorkin Gabapentin reverses the allodynia produced by the administration of anti-GD2 ganglioside, an immunotherapeutic drug Anesth Analg 86 1998 111 116
16. R.H. Gracely, S.A. Lynch, and G.J. Bennett Painful neuropathy: altered central processing maintained dynamically by peripheral input Pain 51 1992 175 194
17. H. Gustafsson, K. Flood, O.G. Berge, E. Brodin, L. Olgart, and C.O. Stiller Gabapentin reverses mechanical allodynia induced by sciatic nerve ischemia and formalin-induced nociception in mice Exp Neurol 182 2003 427 434
18. H.C. Han, D.H. Lee, and J.M. Chung Characteristics of ectopic discharges in a rat neuropathic pain model Pain 84 2000 253 261
19. B. Hemstreet, and M. Lupointe Evidence for the use of gabapentin in the treatment of diabetic peripheral neuropathy Clin Ther 23 4 2001 520 531
20. S.J. Hu, and J.L. Xing An experimental model for chronic compression of dorsalroot ganglion produced by intervertebral foramen stenosis in the rat Pain 77 1998 15 23
21. S.J. Hu, and J. Zhu Sympathetic facilitation of sustained discharges of polymodel nociceptors Pain 38 1989 85 90
22. S.J. Hu, L.M. Chen, and K. Liu Membrane potential oscillations produce repetitive firing in neurons of the rat dorsal root ganglion Chin J Neurosci 4 1997 11 15
23. J.C. Hunter, K.R. Goas, L.R. Hedley, L.O. Jacobson, L. Kassotakis, J. Thompson, and D.J. Fontana The effect of novel anti-epileptic drugs in rat experimental models of acute and chronic pain Eur J Pharmacol 324 1997 153 160
24. T.S. Jensen Anticonvulsants in neuropathic pain: rational and clinical evidence Eur J Pain 6 Suppl A 2002 61 68
25. M. Kaneko, C. Mestre, E.H. Sanchez, and D.L. Hammond Intrathecally administered gabapentin inhibits formalin-evoked nociception and the expression of fos-like immunoreactivity in the spinal cord of the rat J Pharmacol Exp Ther 292 2000 743 751
26. X.G. Liu, and J. Sandkuhler Characterization of long-term potentiation of C-fiber-evoked potentials in spinal dorsal horn of adult rat: essential role of NK1 and NK2 receptors J Neurophysiol 78 1997 1973 1982
27. C.N. Liu, M. Michaelis, R. Amir, and M. Devor Spinal nerve injury enhances subthreshold membrane potential oscillations in DRG neurons: relation to neuropathic pain J Neurophysiol 84 2000 205 215
28. Z.D. Luo, S.R. Chaplan, E.S. Higuera, L.S. Sorkin, K.A. Stauderman, M.E. Williams, and T.L. Yaksh Upregulation of dorsal root ganglion α2/δ calcium channel subunit and its correlation with allodynia in spinal nerve-injured rats J Neurosci 21 6 2001 1868 1875
29. B.V. MacFarlane, A. Wright, J. O'Callaghan, and H.A. Benson Chronic neuropathicpain and its control by drugs Pharmacol Ther 75 1997 1 19
30. H.J. McQuay, M. Tramer, B.A. Nye, D. Carroll, P.J. Wiffen, and R.A. Moore Anticonvulsant drugs for management of pain: a systematic review Br Med J 31 1995 1047 1052
31. R.A. Newton, S. Bingham, P.C. Case, G.J. Sanger, and S.N. Lawson Dorsal root ganglion neurons show increased expression of the calcium channel α2/δ-1 subunit following partial sciatic nerve injury Mol Brain Res 95 2001 1 8
32. K. Obata, H. Yamanaka, T. Fukuoka, D. Yi, A. Tokunaga, N. Hashimoto, H. Yoshikawa, and K. Noguchi Contribution of injured and uninjured dorsal root ganglion neurons to pain behavior and the changes in gene expression follow chronic constriction injury of the sciatic nerve in rat Pain 101 2003 65 77
33. H.L. Pan, J.C. Eisenach, and S.R. Chen Gabapentin suppresses ectopic nerve discharges and reverses allodynia in neuropathic rats J Pharmacol Exp Ther 288 1999 1026 1030
34. J.M. Rosenberg, C. Harrell, H. Ristic, R.A. Werner, and A.M. de Rosayro The effect of gabapentin on neuropathic pain Clin J Pain 13 1997 251 255
35. H. Rosner, L. Rubin, and A. Kestenbaum Gabapentin adjunctive therapy in neuropathic pain states Clin J Pain 12 1996 56 58
36. K. Sheen, and J.M. Chung Signs of neuropathic pain depend on signals from injured nerve fibers in a rat model Brain Res 610 1993 62 68
37. N. Shimoyama, M. Shimoyama, A.M. Davis, C.E. Inturrisi, and K.J. Elliott Spinal gabapentin is antinociceptive in the rat formalin test Neurosci Lett 222 1997 65 67
38. D. Singh, and D.H. Kennedy The use of gabapentin for the treatment of postherpetic neuralgia Clin Ther 25 3 2003 852 889
39. I. Sukhotinsky, E. Ben-Dor, P. Raber, and M. Devor Key role of the dorsal root ganglion in neuropathic tacile hypersensibility Eur J Pain 8 2 2004 135 143
40. 3H]gabapentin binding to a novel site in rat brain: homogenate binding studies Eur J Pharmacol 244 1993 293 301
41. J. Wallin, J.G. Cui, V. Yakhnitsa, G. Schechtmann, B.A. Meyerson, and B. Linderoth Gabapentin and pregabalin suppress tactile allodynia and potentiate spinal cord stimulation in a model of neuropathy Euro J Pain 6 2002 261 272
42. Y.K. Xie, J.M. Zhang, and M. Petersen Function changes in dorsal root ganglion cells after chronic nerve constriction in the rat J Neurophysiol 73 5 1995 1811 1820
43. J.L. Xing, and S.J. Hu Relationship between calcium-dependent potassium channel and ectopic spontaneous discharges of injured dorsal root ganglion neurons in the rat Brain Res 838 1999 218 221
44. J.L. Xing, S.J. Hu, and K.P. Long Subthreshold membrane potential oscillations of type A neurons in injured DRG Brain Res 901 2001 128 136
45. J.L. Xing, S.J. Hu, Z. Jian, and J.H. Duan Subthreshold membrane potential oscillation mediates the excitatory effect of norepinephrine in chronically compressed dorsal root ganglion neurons in the rat Pain 105 2003 177 183
46. Y.W. Yoon, H.S. Na, and J.M. Chung Contributions of injured and intact afferents to neuropathic pain in an experimental rat model Pain 64 1996 27 36