-
1
-
-
0024472699
-
The conserved U.G pair in the 5′ splice site duplex of a group I intron is required in the first but not the second step of self-splicing
-
Barfod, E.T. and Cech, T.R. 1989. The conserved U.G pair in the 5′ splice site duplex of a group I intron is required in the first but not the second step of self-splicing. Mol. Cell. Biol. 9: 3657-3666.
-
(1989)
Mol. Cell. Biol.
, vol.9
, pp. 3657-3666
-
-
Barfod, E.T.1
Cech, T.R.2
-
2
-
-
12344258733
-
Molecular recognition in a trans excision-splicing ribozyme: Non-Watson-Crick base pairs at the 5′ splice site and ωG at the 3′ splice site can play a role in determining the binding register of reaction substrates
-
Baum, D.A., Sinha, J., and Testa, S.M. 2005. Molecular recognition in a trans excision-splicing ribozyme: Non-Watson-Crick base pairs at the 5′ splice site and ωG at the 3′ splice site can play a role in determining the binding register of reaction substrates. Biochemistry 44: 1067-1077.
-
(2005)
Biochemistry
, vol.44
, pp. 1067-1077
-
-
Baum, D.A.1
Sinha, J.2
Testa, S.M.3
-
3
-
-
0037168445
-
Ribozyme-catalyzed excision of targeted sequences from within RNAs
-
Bell, M.A., Johnson, A.K., and Testa, S.M. 2002. Ribozyme-catalyzed excision of targeted sequences from within RNAs. Biochemistry 41: 15327-15333.
-
(2002)
Biochemistry
, vol.41
, pp. 15327-15333
-
-
Bell, M.A.1
Johnson, A.K.2
Testa, S.M.3
-
4
-
-
1842479239
-
Enhancing the second step of the trans excision-splicing reaction of a group I ribozyme by exploiting P9.0 and P10 for intermolecular recognition
-
Bell, M.A., Sinha, J., Johnson, A.K., and Testa, S.M. 2004. Enhancing the second step of the trans excision-splicing reaction of a group I ribozyme by exploiting P9.0 and P10 for intermolecular recognition. Biochemistry 43: 4323-4331.
-
(2004)
Biochemistry
, vol.43
, pp. 4323-4331
-
-
Bell, M.A.1
Sinha, J.2
Johnson, A.K.3
Testa, S.M.4
-
5
-
-
0024370698
-
Selection of the 3′-splice site in group I introns
-
Burke, J.M. 1989. Selection of the 3′-splice site in group I introns. FEBS Lett. 250: 129-133.
-
(1989)
FEBS Lett.
, vol.250
, pp. 129-133
-
-
Burke, J.M.1
-
6
-
-
0025128877
-
A 3′ splice site-binding sequence in the catalytic core of a group I intron
-
Burke, J.M., Esherick, J.S., Burfeind, W.R., and King, J.L. 1990. A 3′ splice site-binding sequence in the catalytic core of a group I intron. Nature 344: 80-82.
-
(1990)
Nature
, vol.344
, pp. 80-82
-
-
Burke, J.M.1
Esherick, J.S.2
Burfeind, W.R.3
King, J.L.4
-
7
-
-
0141743751
-
Efficient and specific repair of sickle β-globin RNA by trans-splicing ribozymes
-
Byun, J., Lan, N., Long, M., and Sullenger, B.A. 2003. Efficient and specific repair of sickle β-globin RNA by trans-splicing ribozymes. RNA 9: 1254-1263.
-
(2003)
RNA
, vol.9
, pp. 1254-1263
-
-
Byun, J.1
Lan, N.2
Long, M.3
Sullenger, B.A.4
-
8
-
-
0025367254
-
Self-splicing of group I introns
-
Cech, T.R. 1990. Self-splicing of group I introns. Annu. Rev. Biochem. 59: 543-568.
-
(1990)
Annu. Rev. Biochem.
, vol.59
, pp. 543-568
-
-
Cech, T.R.1
-
9
-
-
0042388694
-
Phenotype correction of hemophilia A mice by spliceosome-mediated RNA trans-splicing
-
Chao, H., Mansfield, S.G., Bartel, R.C., Hiriyanna, S., Mitchell, L.G., Garcia-Blanco, M.A., and Walsh, C.E. 2003. Phenotype correction of hemophilia A mice by spliceosome-mediated RNA trans-splicing. Nat. Med. 9: 1015-1019.
-
(2003)
Nat. Med.
, vol.9
, pp. 1015-1019
-
-
Chao, H.1
Mansfield, S.G.2
Bartel, R.C.3
Hiriyanna, S.4
Mitchell, L.G.5
Garcia-Blanco, M.A.6
Walsh, C.E.7
-
10
-
-
0007972388
-
RNA structure, not sequence, determines the 5′ splice-site specificity of a group I intron
-
Doudna, J.A., Cormack, B.P., and Szostak, J.W. 1989. RNA structure, not sequence, determines the 5′ splice-site specificity of a group I intron. Proc. Natl. Acad. Sci. 86: 7402-7406.
-
(1989)
Proc. Natl. Acad. Sci.
, vol.86
, pp. 7402-7406
-
-
Doudna, J.A.1
Cormack, B.P.2
Szostak, J.W.3
-
13
-
-
0030866432
-
Evaluating and enhancing ribozyme reaction efficiency in mammalian cells
-
Jones, J.T. and Sullenger, B.A. 1997. Evaluating and enhancing ribozyme reaction efficiency in mammalian cells. Nat. Biotechnol. 15: 902-905.
-
(1997)
Nat. Biotechnol.
, vol.15
, pp. 902-905
-
-
Jones, J.T.1
Sullenger, B.A.2
-
14
-
-
0029896544
-
Tagging ribozyme reaction sites to follow trans-splicing in mammalian cells
-
Jones, J.T., Lee, S.W., and Sullenger, B.A. 1996. Tagging ribozyme reaction sites to follow trans-splicing in mammalian cells. Nat. Med. 2: 643-648.
-
(1996)
Nat. Med.
, vol.2
, pp. 643-648
-
-
Jones, J.T.1
Lee, S.W.2
Sullenger, B.A.3
-
15
-
-
4444371896
-
Restoration of protein synthesis in pancreatic cancer cells by trans-splicing ribozymes
-
Kastanos, E., Hjiantoniou, E., and Phylactou, L.A. 2004. Restoration of protein synthesis in pancreatic cancer cells by trans-splicing ribozymes. Biochem. Biophys. Res. Commun. 322: 930-934.
-
(2004)
Biochem. Biophys. Res. Commun.
, vol.322
, pp. 930-934
-
-
Kastanos, E.1
Hjiantoniou, E.2
Phylactou, L.A.3
-
16
-
-
0142102891
-
Trans-splicing ribozymes for targeted gene delivery
-
Kohler, U., Ayre, B.G., Goodman, H.M., and Haseloff, J. 1999. Trans-splicing ribozymes for targeted gene delivery. J. Mol. Biol. 285: 1935-1950.
-
(1999)
J. Mol. Biol.
, vol.285
, pp. 1935-1950
-
-
Kohler, U.1
Ayre, B.G.2
Goodman, H.M.3
Haseloff, J.4
-
17
-
-
0020417286
-
Self-splicing RNA: Autoexcision and autocyclization of the ribosomal RNA intervening sequence of Tetrahymena
-
Kruger, K., Grabowski, P.J., Zaug, A.J., Sands, J., Gottschling, D.E., and Cech, T.R. 1982. Self-splicing RNA: Autoexcision and autocyclization of the ribosomal RNA intervening sequence of Tetrahymena. Cell 31: 147-157.
-
(1982)
Cell
, vol.31
, pp. 147-157
-
-
Kruger, K.1
Grabowski, P.J.2
Zaug, A.J.3
Sands, J.4
Gottschling, D.E.5
Cech, T.R.6
-
18
-
-
0036137663
-
Partial correction of endogenous ΔF508 CFTR in human cystic fibrosis airway epithelia by spliceosome-mediated RNA trans-splicing
-
Liu, X., Jiang, Q., Mansfield, S.G., Puttaraju, M., Zhang, Y., Zhou, W., Cohn, J.A., Garcia-Blanco, M.A., Mitchell, L.G., and Engelhardt, J.F. 2002. Partial correction of endogenous ΔF508 CFTR in human cystic fibrosis airway epithelia by spliceosome-mediated RNA trans-splicing. Nat. Biotechnol. 20: 47-52.
-
(2002)
Nat. Biotechnol.
, vol.20
, pp. 47-52
-
-
Liu, X.1
Jiang, Q.2
Mansfield, S.G.3
Puttaraju, M.4
Zhang, Y.5
Zhou, W.6
Cohn, J.A.7
Garcia-Blanco, M.A.8
Mitchell, L.G.9
Engelhardt, J.F.10
-
19
-
-
0042388176
-
Ribozymemediated revision of RNA and DNA
-
Long, M.B., Jones III, J.P., Sullenger, B.A., and Byun, J. 2003. Ribozymemediated revision of RNA and DNA. J. Clin. Invest. 112: 312-318.
-
(2003)
J. Clin. Invest.
, vol.112
, pp. 312-318
-
-
Long, M.B.1
Jones III, J.P.2
Sullenger, B.A.3
Byun, J.4
-
20
-
-
0024427177
-
The guanosine binding site of the Tetrahymena ribozyme
-
Michel, F., Hanna, M., Green, R., Bartel, D.P., and Szostak, J.W. 1989. The guanosine binding site of the Tetrahymena ribozyme. Nature 342: 391-395.
-
(1989)
Nature
, vol.342
, pp. 391-395
-
-
Michel, F.1
Hanna, M.2
Green, R.3
Bartel, D.P.4
Szostak, J.W.5
-
21
-
-
32744476900
-
Statistics of repeated measurements: Propagation of random errors
-
Prentice Hall, Harlow, England
-
Miller, J.N. and Miller, J.C. 2000. Statistics of repeated measurements: Propagation of random errors. In Statistics and chemometrics for analytical chemistry, pg. 36. Prentice Hall, Harlow, England.
-
(2000)
Statistics and Chemometrics for Analytical Chemistry
, pp. 36
-
-
Miller, J.N.1
Miller, J.C.2
-
22
-
-
0031940035
-
Ribozyme-mediated trans-splicing of a trinucleotide repeat
-
Phylactou, L.A., Darrah, C., and Wood, M.J. 1998. Ribozyme-mediated trans-splicing of a trinucleotide repeat. Nat. Genet. 18: 378-381.
-
(1998)
Nat. Genet.
, vol.18
, pp. 378-381
-
-
Phylactou, L.A.1
Darrah, C.2
Wood, M.J.3
-
23
-
-
0024120490
-
Determinants of the 3′ splice site for selfsplicing of the Tetrahymena pre-rRNA
-
Price, J.V. and Cech, T.R. 1988. Determinants of the 3′ splice site for selfsplicing of the Tetrahymena pre-rRNA. Genes & Dev. 2: 1439-1447.
-
(1988)
Genes & Dev.
, vol.2
, pp. 1439-1447
-
-
Price, J.V.1
Cech, T.R.2
-
24
-
-
0037383444
-
Ribozymes: Recent advances in the development of RNA tools
-
Puerta-Fernandez, E., Romero-Lopez, C., Barroso-delJesus, A., and Berzal-Herranz, A. 2003. Ribozymes: Recent advances in the development of RNA tools. FEMS Microbiol. Rev. 27: 75-97.
-
(2003)
FEMS Microbiol. Rev.
, vol.27
, pp. 75-97
-
-
Puerta-Fernandez, E.1
Romero-Lopez, C.2
Barroso-DelJesus, A.3
Berzal-Herranz, A.4
-
25
-
-
0032993842
-
Spliceosome-mediated RNA transsplicing as a tool for gene therapy
-
Puttaraju, M., Jamison, S.F., Mansfield, S.G., Garcia-Blanco, M.A., and Mitchell, L.G. 1999. Spliceosome-mediated RNA transsplicing as a tool for gene therapy. Nat. Biotechnol. 17: 246-252.
-
(1999)
Nat. Biotechnol.
, vol.17
, pp. 246-252
-
-
Puttaraju, M.1
Jamison, S.F.2
Mansfield, S.G.3
Garcia-Blanco, M.A.4
Mitchell, L.G.5
-
26
-
-
0036951195
-
Functional repair of a mutant chloride channel using a transsplicing ribozyme
-
Rogers, C.S., Vanoye, C.G., Sullenger, B.A., and George Jr., A.L. 2002. Functional repair of a mutant chloride channel using a transsplicing ribozyme. J. Clin. Invest. 110: 1783-1789.
-
(2002)
J. Clin. Invest.
, vol.110
, pp. 1783-1789
-
-
Rogers, C.S.1
Vanoye, C.G.2
Sullenger, B.A.3
George Jr., A.L.4
-
27
-
-
0037367464
-
Ribozyme-mediated selective induction of new gene activity in hepatitis C virus internal ribosome entry site-expressing cells by targeted trans-splicing
-
Ryu, K.J., Kim, J.H., and Lee, S.W. 2003. Ribozyme-mediated selective induction of new gene activity in hepatitis C virus internal ribosome entry site-expressing cells by targeted trans-splicing. Mol. Ther. 7: 386-395.
-
(2003)
Mol. Ther.
, vol.7
, pp. 386-395
-
-
Ryu, K.J.1
Kim, J.H.2
Lee, S.W.3
-
28
-
-
0027362708
-
A shortened form of the Tetrahymena thermophila group I intron can catalyze the complete splicing reaction in trans
-
Sargueil, B. and Tanner, N.K. 1993. A shortened form of the Tetrahymena thermophila group I intron can catalyze the complete splicing reaction in trans. J. Mol. Biol. 233: 629-643.
-
(1993)
J. Mol. Biol.
, vol.233
, pp. 629-643
-
-
Sargueil, B.1
Tanner, N.K.2
-
29
-
-
0348014774
-
Approaches for the sequence-specific knockdown of mRNA
-
Scherer, L.J. and Rossi, J.J. 2003. Approaches for the sequence-specific knockdown of mRNA. Nat. Biotechnol. 21: 1457-1465.
-
(2003)
Nat. Biotechnol.
, vol.21
, pp. 1457-1465
-
-
Scherer, L.J.1
Rossi, J.J.2
-
30
-
-
4344614627
-
Ribozyme-mediated induction of apoptosis in human cancer cells by targeted repair of mutant p53 RNA
-
Shin, K.S., Sullenger, B.A., and Lee, S.W. 2004. Ribozyme-mediated induction of apoptosis in human cancer cells by targeted repair of mutant p53 RNA. Mol. Ther. 10: 365-372.
-
(2004)
Mol. Ther.
, vol.10
, pp. 365-372
-
-
Shin, K.S.1
Sullenger, B.A.2
Lee, S.W.3
-
31
-
-
0025283867
-
Use of T7 RNA polymerase to direct expression of cloned genes
-
Studier, F.W., Rosenberg, A.H., Dunn, J.J., and Dubendorff, J.W. 1990. Use of T7 RNA polymerase to direct expression of cloned genes. Methods Enzymol. 185: 60-89.
-
(1990)
Methods Enzymol.
, vol.185
, pp. 60-89
-
-
Studier, F.W.1
Rosenberg, A.H.2
Dunn, J.J.3
Dubendorff, J.W.4
-
32
-
-
0027987902
-
Ribozyme-mediated repair of defective mRNA by targeted, trans-splicing
-
Sullenger, B.A. and Cech, T.R. 1994. Ribozyme-mediated repair of defective mRNA by targeted, trans-splicing. Nature 371: 619-622.
-
(1994)
Nature
, vol.371
, pp. 619-622
-
-
Sullenger, B.A.1
Cech, T.R.2
-
33
-
-
0037062920
-
Emerging clinical applications of RNA
-
Sullenger, B.A. and Gilboa, E. 2002. Emerging clinical applications of RNA. Nature 418: 252-258.
-
(2002)
Nature
, vol.418
, pp. 252-258
-
-
Sullenger, B.A.1
Gilboa, E.2
-
34
-
-
0030720935
-
A Pneumocystis carinii group I intron ribozyme that does not require 2′ OH groups on its 5′ exon mimic for binding to the catalytic core
-
Testa, S.M., Haidaris, C.G., Gigliotti, F., and Turner, D.H. 1997. A Pneumocystis carinii group I intron ribozyme that does not require 2′ OH groups on its 5′ exon mimic for binding to the catalytic core. Biochemistry 36: 15303-15314.
-
(1997)
Biochemistry
, vol.36
, pp. 15303-15314
-
-
Testa, S.M.1
Haidaris, C.G.2
Gigliotti, F.3
Turner, D.H.4
-
35
-
-
0027406037
-
Requirements of a group I intron for reactions at the 3′ splice site
-
van der Horst, G. and Inoue, T. 1993. Requirements of a group I intron for reactions at the 3′ splice site. J. Mol. Biol. 229: 685-694.
-
(1993)
J. Mol. Biol.
, vol.229
, pp. 685-694
-
-
Van Der Horst, G.1
Inoue, T.2
-
36
-
-
0022649937
-
The intervening sequence RNA of Tetrahymena is an enzyme
-
Zaug, A.J. and Cech, T.R. 1986. The intervening sequence RNA of Tetrahymena is an enzyme. Science 231: 470-475.
-
(1986)
Science
, vol.231
, pp. 470-475
-
-
Zaug, A.J.1
Cech, T.R.2
-
37
-
-
0022975535
-
The Tetrahymena ribozyme acts like an RNA restriction endonuclease
-
Zaug, A.J., Been, M.D., and Cech, T.R. 1986. The Tetrahymena ribozyme acts like an RNA restriction endonuclease. Nature 324: 429-433.
-
(1986)
Nature
, vol.324
, pp. 429-433
-
-
Zaug, A.J.1
Been, M.D.2
Cech, T.R.3
|