Tagging ribozyme reaction sites to follow trans-splicing in mammalian cells

Nature Medicine

Volumn 2, Issue 6, 1996, Pages 643-648

  Jones, Joshua T ^a   Lee, Seong Wook ^a   Sullenger, Bruce A ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; ENZYME ACTIVITY; FIBROBLAST; GENE THERAPY; NUCLEOTIDE SEQUENCE; PATHOGENESIS; PRIORITY JOURNAL; RNA SEQUENCE; RNA SPLICING; SEQUENCE ANALYSIS;

3T3 CELLS; ANIMALS; BASE SEQUENCE; CYTOPLASM; DNA-DIRECTED RNA POLYMERASES; LAC OPERON; MICE; MODELS, GENETIC; MOLECULAR SEQUENCE DATA; PLASMIDS; POLYMERASE CHAIN REACTION; RNA; RNA SPLICING; RNA, BACTERIAL; RNA, CATALYTIC; SUBSTRATE SPECIFICITY; TETRAHYMENA THERMOPHILA; TRANSCRIPTION, GENETIC; TRANSFECTION; VIRAL PROTEINS;

MAMMALIA; MURINAE;

EID: 0029896544     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm0696-643     Document Type: Article

References (15)

1. Cech, T.R. Self-splicing of group I introns. Annu. Rev. Biochem. 59, 543-568 (1990).
2. Zaug, A.J., Been, M.D. & Cech, T.R. The Tetrahymena ribozyme acts like an RNA restriction endonuclease. Nature 324, 429-433 (1986).
3. Uhlenbeck, O.C. A small catalytic oligoribonucleotide. Nature 328, 596-600 (1987).
4. Haseloff, J. & Gerlach W.L. Simple RNA enzymes with new and highly specific endoribonuclease activities. Nature 334, 585-591 (1988).
5. Feldstein, P.A., Buzayan, J.M. & Bruening, G. Two sequences participating in the autolytic processing of satellite tobacco ringspot virus complementary RNA. Gene 2, 53-61 (1989).
6. Hampel, A., Tritz, R., Hicks, M. & Cruz, P. 'Hairpin' catalytic RNA model: Evidence for helices and sequence requirement for substrate RNA. Nucleic Acids Res. 18, 299-304 (1990).
7. Chowrira, B.M. & Burke, J.M. Binding and cleavage of nucleic acids by the hairpin ribozyme. Biochemistry 30, 8518-8522 (1991).
8. Forester, A.C. & Altman, S. External guide sequence for an RNA enzyme. Science 249, 783-786 (1990).
9. Perrotta, A.T. & Been, M.D. Cleavage of oligoribonucleotides by a ribozyme derived from the hepatitis delta virus RNA sequence. Biochemistry 31, 16-21 (1992).
10. Sullenger, B.A. & Cech, T.R. Ribozyme-mediated repair of defective mRNA by targeted trans-splicing. Nature 371, 619-622 (1994).
11. Cech, T.R. Ribozymes and their medical implications. J. Am. Med. Assoc. 260, 3030-3034 (1988).
12. Rossi, J.J. Ribozymes. Curr. Opin. Biotechnol. 3, 3-7 (1992).
13. Yu, M., Poeschla, E. & Wong-Staal, F. Progress towards gene therapy for HIV infection. Gene Ther. 1, 13-26 (1994).
14. Sullenger, B.A. Revising messages traveling along the cellular information superhighway. Chem. Biol. 2, 249-253 (1995).
15. Inoue, T., Sullivan, F.X. & Cech, T.R. Intermolecular exon ligation of the rRNA precursor of Tetrahymena: Oligonucleotides can function as 5′ exons. Cell 43, 431-437 (1985).