Different pharmacological profile of two closely related endocannabinoid ester analogs

Life Sciences

Volumn 77, Issue 13, 2005, Pages 1425-1440

  Bobrov, Mikhail ^a   Gretskaya, Natalia ^a   Payet, Olivier ^b   Bezuglov, Vladimir ^a   Durand, Thierry ^b   Maurin, Laurence ^b   Tourrel, Frank ^c   Adjali, Oumeya ^b   Rinaldi Carmona, Murielle ^c   Muller, Agnès ^b  

^a SHEMYAKIN OVCHINNIKOV INSTITUTE OF BIOORGANIC CHEMISTRY   (Russian Federation)

^b CNRS   (France)

^c SANOFI   (France)

Author keywords

2 arachidonoylglycerol; Adenylyl cyclase; Anandamide; Cannabinoid tetrad; CB1 and CB2 receptors; Endocannabinoids esters; Neuroprotection

Indexed keywords

4 (1,1 DIMETHYLHEPTYL) 1',2',3',4',5',6' HEXAHYDRO 2,3' DIHYDROXY 6' (3 HYDROXYPROPYL)BIPHENYL; ADENYLATE CYCLASE; ALPHA,ALPHA DIMETHYLARACHIDONOYLETHYLENEGLYCOL; ARACHIDONOYLETHYLENEGLYCOL; CANNABINOID 1 RECEPTOR; CANNABINOID 2 RECEPTOR; CANNABINOID RECEPTOR; CB1 CANNABINOID RECEPTOR AGONIST; CB2 CANNABINOID RECEPTOR AGONIST; ENDOCANNABINOID; ESTER DERIVATIVE; GLUTAMIC ACID; NEUROPROTECTIVE AGENT; OXYGEN; TRITIUM; UNCLASSIFIED DRUG;

ANALGESIA; ANIMAL TISSUE; ARTICLE; BRAIN CELL; BRAIN MEMBRANE; CATALEPSY; CELL MOTILITY; CONTROLLED STUDY; DRUG ACTIVITY; DRUG BINDING; DRUG EFFECT; DRUG EFFICACY; DRUG POTENCY; ENZYME ACTIVITY; HYDROLYSIS; NEUROPROTECTION; NONHUMAN; PROTEIN EXPRESSION; RAT; RECTUM TEMPERATURE; RODENT;

ANIMALS; ARACHIDONIC ACIDS; BINDING, COMPETITIVE; CELLS, CULTURED; CHO CELLS; CRICETINAE; CYCLIC AMP; CYCLOHEXANOLS; ENDOCANNABINOIDS; ETHYLENE GLYCOLS; FEMALE; NEUROPROTECTIVE AGENTS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, CANNABINOID, CB2;

RODENTIA;

EID: 21844461296     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2005.02.011     Document Type: Article

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