X-ray absorption studies of human matrix metalloproteinase-2 (MMP-2) bound to a highly selective mechanism-based inhibitor. Comparison with the latent and active forms of the enzyme

Journal of Biological Chemistry

Volumn 276, Issue 20, 2001, Pages 17125-17131

  Kleifeld, Oded ^a   Kotra, Lakshmi P ^b   Gervasi, David C ^b,c   Brown, Stephen ^b   Bernardo, M Margarida ^b,c   Fridman, Rafael ^b,c   Mobashery, Shahriar ^b   Sagi, Irit ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^b WAYNE STATE UNIVERSITY   (United States)

^c WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABSORPTION SPECTROSCOPY; CATALYSIS; CONFORMATIONS; ENZYME INHIBITION; TUMORS; X RAY SPECTROSCOPY;

ANGIOGENESIS;

BIOCHEMISTRY;

GELATINASE A; GELATINASE A INHIBITOR; GELATINASE B; GELATINASE B INHIBITOR; MATRIX METALLOPROTEINASE INHIBITOR; PROTEINASE; SB 3CT; UNCLASSIFIED DRUG; ZINC DERIVATIVE; ENZYME PRECURSOR; PROTEINASE INHIBITOR; RECOMBINANT PROTEIN; SB 3CT COMPOUND; SINGLE HETEROCYCLIC RINGS; SULFONE; ZINC;

ABSORPTION SPECTROPHOTOMETRY; ANGIOGENESIS; ARTICLE; CATALYSIS; CHEMICAL STRUCTURE; CONFORMATIONAL TRANSITION; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME INHIBITION; ENZYME MECHANISM; EXTRACELLULAR MATRIX; HUMAN; HUMAN CELL; HYDROLYSIS; LATENT PERIOD; MALIGNANT NEOPLASTIC DISEASE; METAL BINDING; METASTASIS; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; BINDING SITE; CHEMISTRY; DRUG ANTAGONISM; ENZYME ACTIVATION; KINETICS; METABOLISM; METHODOLOGY; RADIODENSITOMETRY;

BINDING SITES; DENSITOMETRY, X-RAY; ENZYME ACTIVATION; ENZYME PRECURSORS; HETEROCYCLIC COMPOUNDS, 1-RING; HUMANS; KINETICS; MATRIX METALLOPROTEINASE 2; MODELS, MOLECULAR; PROTEASE INHIBITORS; RECOMBINANT PROTEINS; SULFONES; ZINC;

EID: 0035907387     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M011604200     Document Type: Article

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