Pathological aggression in "Fierce" mice corrected by human nuclear receptor 2E1

Journal of Neuroscience

Volumn 25, Issue 27, 2005, Pages 6263-6270

  Abrahams, Brett S ^a   Kwok, Melvin C H ^a   Trinh, Eric ^a   Budaghzadeh, Saeed ^a   Hossain, Sazzad M ^a   Simpson, Elizabeth M ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

6q21 6q22; Behavior; Genetic disease; Tlx; Transgenic rescue; Violence

Indexed keywords

CELL NUCLEUS RECEPTOR; COMPLEMENTARY DNA; NUCLEAR RECEPTOR 2E1; UNCLASSIFIED DRUG;

AGGRESSION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR DISORDER; BRAIN DEVELOPMENT; CHROMOSOME 6Q; EYE DEVELOPMENT; GENE DELETION; GENE LOCUS; GENETIC DISORDER; GENOTYPE; MENTAL DISEASE; MOUSE; NONHUMAN; NR2E1 GENE; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; TRANSGENE; TRANSGENIC MOUSE; VIOLENCE;

ABNORMALITIES; AGGRESSION; AGONISTIC BEHAVIOR; ANIMALS; BRAIN; CEREBRAL CORTEX; CROSSES, GENETIC; EXPLORATORY BEHAVIOR; EYE ABNORMALITIES; FEMALE; GENOTYPE; HUMANS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; OLFACTORY BULB; PHENOTYPE; PROMOTER REGIONS (GENETICS); RECEPTORS, CYTOPLASMIC AND NUCLEAR; REGULATORY SEQUENCES, NUCLEIC ACID; RETINA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SPECIES SPECIFICITY; TERRITORIALITY;

EID: 21844432389     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.4757-04.2005     Document Type: Article

References (47)

1. Abrahams BS, Chong ACO, Nisha M, Milette D, Brewster DA, Berry ML, Muratkhodjaev F, Mai S, Rajcan-Separovic E, Simpson EM (2003) Metaphase FISHing of transgenic mice recommended: FISH and SKY define BAC-mediated balanced translocation. Genesis 36:134-141.
2. Banks KG, Johnson KA, Lerner CP, Mahaffey CL, Bronson RT, Simpson EM (2003) Retroposon compensatory mechanism hypothesis not supported: Zfa knockout mice are fertile. Genomics 82:254-260.
3. Brown NL, Kanekar S, Vetter ML, Tucker PK, Gemza DL, Glaser T (1998) Math5 encodes a murine basic helix-loop-helix transcription factor expressed during early stages of retinal neurogenesis. Development 125:4821-4833.
4. Buervenich S, Carmine A, Arvidsson M, Xiang F, Zhang Z, Sydow O, Jonsson EG, Sedvall GC, Leonard S, Ross RG, Freedman R, Chowdari KV, Nimgaonkar VL, Perlmann T, Anvret M, Olson L (2000) NURR1 mutations in cases of schizophrenia and manic-depressive disorder. Am J Med Genet 96:808-813.
5. Caspi A, McClay J, Moffitt TE, Mill J, Martin J, Craig IW, Taylor A, Poulton R (2002) Role of genotype in the cycle of violence in maltreated children. Science 297:851-854.
6. Chang B, Smith RS, Peters M, Savinova OV, Hawes NL, Zabaleta A, Nusinowitz S, Martin JE, Davisson ML, Cepko CL, Hogan BL, John SW (2001) Haploinsufficient Bmp4 ocular phenotypes include anterior segment dysgenesis with elevated intraocular pressure. BMC Genet 2:18.
7. Chen JY, Levy-Wilson B, Goodart S, Cooper AD (2002) Mice expressing the human CYP7A1 gene in the mouse CYP7A1 knock-out background lack induction of CYP7A1 expression by cholesterol feeding and have increased hypercholesterolemia when fed a high fat diet. J Biol Chem 277:42588-42595.
8. Chen YH, Tsai MT, Shaw CK, Chen CH (2001) Mutation analysis of the human NR4A2 gene, an essential gene for midbrain dopaminergic neurogenesis, in schizophrenic patients. Am J Med Genet 105:753-757.
9. Cheung C, Akiyama TE, Ward JM, Nicol CJ, Feigenbaum L, Vinson C, Gonzalez FJ (2004) Diminished hepatocellular proliferation in mice humanized for the nuclear receptor peroxisome proliferator-activated receptor alpha. Cancer Res 64:3849-3854.
10. Crowley JJ, Jones MD, O'Leary OF, Lucki I (2004) Automated tests for measuring the effects of antidepressanti in mice. Pharmacol Biochem Behav 78:269-274.
11. Davis S, Thomas A, Perry R, Oakley A, Kalaria RN, O'Brien JT (2002) Glial fibrillary acidic protein in late life major depressive disorder: an immunocytochemical study. J Neurol Neurosurg Psychiatry 73:556-560.
12. Dick DM, Foroud T, Flury L, Bowman ES, Miller MJ, Rau NL, Moe PR, Samavedy N, El-Mallakh R, Manji H, Glitz DA, Meyer ET, Smiley C, Hahn R, Widmark C, McKinney R, Sutton L, Ballas C, Grice D, Berrettini W, et al. (2003) Genomewide linkage analyses of bipolar disorder: a new sample of 250 pedigrees from the National Institute of Mental Health Genetics Initiative. Am J Hum Genet 73:107-114.
13. Enard W, Przeworski M, Fisher SE, Lai CS, Wiebe V, Kitano T, Monaco AP, Paabo S (2002) Molecular evolution of FOXP2, a gene involved in speech and language. Nature 418:869-872.
14. Franklin KBJ, Paxinos G (1997) The mouse brain in stereotaxic coordinates, Ed 1. London: Academic.
15. Goodman AB (1998) Three independent lines of evidence suggest retinoids as causal to schizophrenia. Proc Natl Acad Sci USA 95:7240-7244.
16. Hawes NL, Smith RS, Chang B, Davisson M, Heckenlively JR, John SW (1999) Mouse fundus photography and angiography: a catalogue of normal and mutant phenotypes. Mol Vis 5:22-29.
17. Heyman I, Frampton I, van Heyningen V, Hanson I, Teague P, Taylor A, Simonoff E (1999) Psychiatric disorder and cognitive function in a family with an inherited novel mutation of the developmental control gene PAX6. Psychiatr Genet 9:85-90.
18. Hodgson JG, Smith DJ, McCutcheon K, Koide HB, Nishiyama K, Dinulos MB, Stevens ME, Bissada N, Nasir J, Kanazawa I, Disteche CM, Rubin EM, Hayden MR (1996) Human huntingtin derived from YAC trans-genes compensates for loss of murine huntingtin by rescue of the embryonic lethal phenorype. Hum Mol Genet 5:1875-1885.
19. Hossain SM, Wong BKY, Simpson EM (2004) The dark phase improves genetic discrimination for some high throughput mouse behavioral phenotyping. Genes Brain Behav 3:167-177.
20. Iwayama-Shigeno Y, Yamada K, Toyotii T, Shimizu H, Hattori E, Yoshitsugu K, Fujisawa T, Yoshida Y, Kobayashi T, Toru M, Kurumaji A, Detera-Wadleigh S, Yoshikawa T (2003) Distribution of haplotypes derived from three common variants of the NR4A2 gene in Japanese patients with schizophrenia. Am J Med Genet 118B:20-24.
21. Jackson A, Panayiotidis P, Foroni L (1998) The human homologue of the Drosophila tailless gene (TLX): characterization and mapping to a region of common deletion in human lymphoid leukemia on chromosome 6q21. Genomics 50:34-43.
22. Kobayashi M, Yu RT, Yasuda K, Umesono K (2000) Cell-type-specific regulation of the retinoic acid receptor mediated by the orphan nuclear receptor TLX. Mol Cell Biol 20:8731-8739.
23. Krezel W, Ghyselinck N, Samad TA, Dupe V, Kastner P, Borrelli E, Chambon P (1998) Impaired locomotion and dopamine signaling in retinoid receptor mutant mice. Science 279:863-867.
24. Kumar RA, Chan KL, Wong AH, Little KQ, Rajcan-Separovic E, Abrahams BS, Simpson EM (2004) Unexpected embryonic stem (ES) cell mutations represent a concern in gene targeting: lessons from "fierce" mice. Genesis 38:51-57.
25. Land PW, Monaghan AP (2003) Expression of the transcription factor, tailless, is required for formation of superficial cortical layers. Cereb Cortex 13:921-931.
26. Middleton FA, Pato MT, Gentile KL, Morley CP, Zhao X, Eisener AF, Brown A, Petryshen TL, Kirby AN, Medeiros H, Carvalho C, Macedo A, Dourado A, Coelho I, Valente J, Soares MJ, Ferreira CP, Lei M, Azevedo MH, Kennedy JL, et al. (2004) Genomewide linkage analysis of bipolar disorder by use of a high-density single-nucleotide-polymorphism (SNP) genotyping assay: a comparison with microsatellite marker assays and finding of significant linkage to chromosome 6q22. Am J Hum Genet 74:886-897.
27. Miyawaki T, Uemura A, Dezawa M, Yu RT, Ide C, Nishikawa S, Honda Y, Tanabe Y, Tanabe T (2004) Tlx, an orphan nuclear receptor, regulates cell numbers and astrocyte development in the developing retina. J Neurosci 24:8124-8134.
28. Monaghan AP, Grau E, Bock D, Schütz G (1995) The mouse homolog of the orphan nuclear receptor tailless is expressed in the developing forebrain. Development 121:839-853.
29. Monaghan AP, Bock D, Gass P, Schwager A, Wolfer DP, Lipp HP, Schutz G (1997) Defective limbic system in mice lacking the tailless gene. Nature 390:515-517.
30. Nguyen V, Deschet K, Henrich T, Godet E, Joly JS, Wittbrodt J, Chourrout D, Bourrat F (1999) Morphogenesis of the optic tectum in the medaka (Oryzias latipes): a morphological and molecular study, with special emphasis on cell proliferation. J Comp Neurol 413:385-404.
31. Ouagazzal AM, Moreau JL, Pauly-Evers M, Jenck F (2003) Impact of environmental housing conditions on the emotional responses of mice deficient for nociceptin/orphanin FQ peptide precursor gene. Behav Brain Res 144:111-117.
32. Owen MJ, Williams NM, O'Donovan MC (2004) The molecular genetics of schizophrenia: new findings promise new insights. Mol Psychiatry 9:14-27.
33. Peier AM, McIlwain KL, Kenneson A, Warren ST, Paylor R, Nelson DL (2000) (Over)correction of FMR1 deficiency with YAC transgenics: behavioral and physical features. Hum Mol Genet 9:1145-1159.
34. Pook MA, Al-Mahdawi S, Carroll CJ, Cossee M, Puccio H, Lawrence L, Clark P, Lowrie MB, Bradley JL, Cooper JM, Koenig M, Chamberlain S (2001) Rescue of the Friedreich's ataxia knockout mouse by human YAC transgenesis. Neurogenetics 3:185-193.
35. Rothermundt M, Ponath G, Arolt V (2004) S100B in schizophrenic psychosis. Int Rev Neurobiol 59:445-470.
36. Roy K, Kuznicki K, Wu Q, Sun Z, Bock D, Schutz G, Vranich N, Monaghan AP (2004) The Tlx gene regulates the timing of neurogenesis in the cortex. J Neurosci 24:8333-8345.
37. Schedl A, Ross A, Lee M, Engelkamp D, Rashbass P, van Heyningen V, Hastie ND (1996) Influence of PAX6 gene dosage on development: overexpression causes severe eye abnormalities. Cell 86:71-82.
38. Shi Y, Chichung Lie D, Taupin P, Nakashima K, Ray J, Yu RT, Gage FH, Evans RM (2004) Expression and function of orphan nuclear receptor TLX in adult neural stem cells. Nature 427:78-83.
39. Silva A, Simpson EM, Takahashi JS, Lipp H-P, Nakanishi S, Wehner JM, Giese KP, Tully T, Abel T, Chapman PF, Fox K, Grant S, Itohara S, Lathe R, Mayford M, McNamara JO, Morris RJ, Picciotto M, Roder J, Shin H-S, et al. (1997) Mutant mice and neuroscience: recommendations concerning genetic background. Neuron 19:755-759.
40. Stenman J, Yu RT, Evans RM, Campbell K (2003a) Tlx and Pax6 co-operate genetically to establish the pallio-subpallial boundary in the embryonic mouse telencephalon. Development 130:1113-1122.
41. Stenman JM, Wang B, Campbell K (2003b) Tlx controls proliferation and patterning of lateral telencephalic progenitor domains. J Neurosci 23:10568-10576.
42. Stober G, Syagailo YV, Okladnova O, Jungkunz G, Knapp M, Beckmann H, Lesch KP (1999) Functional PAX-6 gene-linked polymorphic region: potential association with paranoid schizophrenia. Biol Psychiatry 45:1585-1591.
43. Tandon K, McGuffin P (2002) The genetic basis for psychiatric illness in man. Eur J Neurosci 16:403-407.
44. Van Loo PL, Mol JA, Koolhaas JM, Van Zutphen BF, Baumans V (2001) Modulation of aggression in male mice: influence of group size and cage size. Physiol Behav 72:675-683.
45. Young KA, Berry ML, Mahaffey CL, Saionz JR, Hawes NL, Chang B, Zheng QY, Smith RS, Bronson RT, Nelson RJ, Simpson EM (2002) Fierce: a new mouse deletion of Nr2el; violent behaviour and ocular abnormalities are background-dependent. Behav Brain Res 132:145-158.
46. Younossi-Hartenstein A, Green P, Liaw GJ, Rudolph K, Lengyel J, Hartenstein V (1997) Control of early neurogenesis of the Drosophila brain by the head gap genes til, otd, ems, and btd. Dev Biol 182:270-283.
47. Yu RT, Chiang MY, Tanabe T, Kobayashi M, Yasuda K, Evans RM, Umesono K (2000) The orphan nuclear receptor Tlx regulates Pax2 and is essential for vision. Proc Natl Acad Sci USA 97:2621-2625.