NURR1 mutations in cases of schizophrenia and manic-depressive disorder

American Journal of Medical Genetics - Neuropsychiatric Genetics

Volumn 96, Issue 6, 2000, Pages 808-813

  Buervenich, Silvia ^a,b   Carmine, Andrea ^a,b   Arvidsson, Mariette ^a   Xiang, Fengqing ^a,b   Zhang, Zhiping ^a,b   Sydow, Olof ^c   Jönsson, Erik G ^a   Sedvall, Göran C ^a   Leonard, Sherry ^d   Ross, Randal G ^d   Freedman, Robert ^d   Chowdari, Kodavali V ^e   Nimgaonkar, Vishwajit L ^e,f   Perlmann, Thomas ^a   Anvret, Maria ^a,b   Olson, Lars ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c DANDERYD HOSPITAL   (Sweden)

^d UNIVERSITY OF COLORADO   (United States)

^e UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^f UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

Complex diseases; Genetic variant; Nervous system; NGFI B family; Nuclear orphan receptor; Parkinson

Indexed keywords

NUCLEAR RECEPTOR RELATED FACTOR 1; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CONTROLLED STUDY; DNA SEQUENCE; EXON; GENE AMPLIFICATION; GENE MUTATION; GENETIC TRANSCRIPTION; GENETIC VARIABILITY; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MANIC DEPRESSIVE PSYCHOSIS; MISSENSE MUTATION; PRIORITY JOURNAL; RECEPTOR GENE; SCHIZOPHRENIA; SEQUENCE ANALYSIS;

MUS MUSCULUS;

EID: 0034606207     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/1096-8628(20001204)96:6<808::aid-ajmg23>3.0.co;2-e     Document Type: Article

References (30)

1. Susceptibility loci for bipolar disorder: Overlap with inherited vulnerability to schizophrenia
2. The current status of the dopamine hypothesis of schizophrenia
3. Dopamine biosynthesis is selectively abolished in substantia nigra/ventral tegmental area but not in hypothalamic neurons in mice with targeted disruption of the Nurr1 gene
4. Organization, sequence, chromosomal localization, and promoter identification of the mouse orphan nuclear receptor Nurr1 gene
5. Dopamine receptor binding predicts clinical and pharmacological potencies of antischizophrenic drugs
6. Parkinson's Disease Society Brain Bank, London: Overview and research
7. A dopaminergic mechanism in mania
8. Three independent lines of evidence suggest retinoids as causal to schizophrenia
9. A gene inducible by serum growth factors encodes a member of the steroid and thyroid hormone receptor superfamily
10. Biochemical aspects of Parkinson's disease
11. Molecular cloning of the human Nurr1 gene: Characterization of the human gene and cDNAs
12. Lack of association between schizophrenia and alleles in the dopamine D3 receptor gene
13. Impaired locomotion and dopamine signaling in retinoid receptor mutant mice
14. NOT, a human immediate-early response gene closely related to the steroid/thyroid hormone receptor NAK1/TR3
15. High levels of a retinoic acid-generating dehydrogenase in the meso-telencephalic dopamine system
16. Association study of schizophrenia and the dopamine D3 receptor gene locus in two independent samples
17. An isoform of Nurr1 functions as a negative inhibitor of the NGFI-B family signaling
18. A novel pathway for vitamin A signaling mediated by RXR heterodimerization with NGFI-B and NURR1
19. Novel dimeric Nur77 signaling mechanism in endocrine and lymphoid cells
20. Schizophrenia and the serotonin transporter gene
21. Regulation of dopaminergic pathways by retinoids: Activation of the D2 receptor promoter by members of the retinoic acid receptor-retinoid X receptor family
22. Cloning and structural organization of the gene encoding the murine nuclear receptor transcription factor, NURR1
23. Nurr1 is essential for the induction of the dopaminergic phenotype and the survival of ventral mesencephalic late dopaminergic precursor neurons
24. Organization of the human orphan nuclear receptor Nurr1 gene
25. Direct repeats as selective response elements for the thyroid hormone, retinoic acid, and vitamin D3 receptors
26. Cellular expression of the immediate early transcription factors Nurr1 and NGFI-B suggests a gene regulatory role in several brain regions including the nigrostriatal dopamine system
27. Dopamine neuron agenesis in Nurr1-deficient mice
28. Role of retinoids in the CNS: Differential expression of retinoid binding proteins and receptors and evidence for presence of retinoic acid