Biodistribution, plasma kinetics and quantification of single-pass pulmonary clearance of adrenomedullin

Clinical Science

Volumn 109, Issue 1, 2005, Pages 97-102

  Dupuis, Jocelyn ^a   Caron, Alexandre ^a   Ruël, Nathalie ^a  

^a MONTREAL HEART INSTITUTE   (Canada)

Author keywords

Adrenomedullin; Peptide hormone; Pharmacokinetics; Pulmonary circulation; Vasoactive agent

Indexed keywords

ADRENOMEDULLIN; ADRENOMEDULLIN I 125; CALCITONIN GENE RELATED PEPTIDE; CALCITONIN GENE RELATED PEPTIDE RECEPTOR; IODINE 125; PEPTIDE; UNCLASSIFIED DRUG; VASOACTIVE AGENT;

ANIMAL MODEL; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; COMPARTMENT MODEL; CONTROLLED STUDY; DOG; FIRST PASS EFFECT; HALF LIFE TIME; IN VIVO STUDY; INDICATOR DILUTION CURVE; LUNG CIRCULATION; LUNG CLEARANCE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ADRENOMEDULLIN; ANIMALS; DOGS; INJECTIONS, INTRA-ARTERIAL; INJECTIONS, INTRAVENOUS; IODINE RADIOISOTOPES; LUNG; MALE; METABOLIC CLEARANCE RATE; PEPTIDES; PULMONARY CIRCULATION; RADIOPHARMACEUTICALS; RATS; RATS, SPRAGUE-DAWLEY; TISSUE DISTRIBUTION; VASODILATOR AGENTS;

EID: 21744447714     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/CS20040357     Document Type: Article

References (22)

1. Kitamura, K., Sakata, J., Kangawa, K., Kojima, M., Matsuo, H. and Eto, T. (1994) Cloning and characterization of cDNA encoding a precursor for human adrenomedullin. Biochem. Biophys. Res. Commun. 194, 720-725
2. Sugo, S., Minamino, N., Kangawa, K. et al. (1994) Endothelial cells actively synthesize and secrete adrenomedullin. Biochem. Biophys. Res. Commun. 201, 1160-1166
3. Hinson, J. P., Kapas, S. and Smith, D. M. (2000) Adrenomedullin, a multifunctional regulatory peptide. Endocr. Rev. 21, 138-167
4. Hay, D. L. and Smith, D. M. (2001) Receptors: molecular identity and function. Peptides 22, 1753-1763
5. Kuwasako, K., Kitamura, K., Ito, K. et al. (2001) The seven amino acids of human RAMP2 (86) and RAMP3 (59) are critical for agonist binding to human adrenomedullin receptors. J. Biol. Chem. 276, 49459-49465
6. Poyner, D. R., Sexton, P. M., Marshall, I. et al. (2002) International Union of Pharmacology. XXXII. The mammalian calcitonin gene-related peptides, adrenomedullin, amylin, and calcitonin receptors. Pharmacol. Rev. 54, 233-246
7. Eguchi, S., Hirata, Y., Iwasaki, H. et al. (1994) Structure-activity relationship of adrenomedullin, a novel vasodilatory peptide, in cultured rat vascular smooth muscle cells. Endocrinology 135, 2454-2458
8. Sabates, B., Granger, T., Choe, E. et al. (1996) Adrenomedullin is inactivated in the lungs of neonatal piglets. J. Pharm. Pharmacol. 48, 578-580
9. Hirayama, N., Kitamura, K., Imamura, T., Kato, J., Koiwaya, Y. and Eto, T. (1999) Secretion and clearance of the mature form of adrenomedullin in humans. Life Sci. 64, 2505-2509
10. Nishikimi, T., Kitamura, K., Saito, Y. et al. (1994) Clinical studies on the sites of production and clearance of circulating adrenomedullin in human subjects. Hypertension 24, 600-604
11. Nishikimi, T., Matsuoka, H., Shimada, K., Matsuo, H. and Kangawa, K. (2004) Production and clearance sites of two molecular forms of adrenomedullin in human plasma. Am. J. Hypertens. 13, 1032-1034
12. Nishikimi, T., Nagata, S., Sasaki, T. et al. (2001) The active molecular form of plasma adrenomedullin is extracted in the pulmonary circulation in patients with mitral stenosis: Possible role of adrenomedullin in pulmonary hypertension. Clin. Sci. 100, 61-66
13. B receptors. J. Appl. Physiol. 81, 1510-1515
14. Kitamura, K., Kato, J., Kawamoto, M. et al. (1998) The intermediate form of glycine-extended adrenomedullin is the major circulating molecular form in human plasma. Biochem. Biophys. Res. Commun. 244, 551-555
15. Martinez, A., Miller, M. J., Catt, K. J. and Cuttitta, F. (1997) Adrenomedullin receptor expression in human lung and in pulmonary tumors. J. Histochem. Cytochem. 45, 159-164
16. Owji, A. A., Smith, D. M., Coppock, H. A. et al. (1995) An abundant and specific binding site for the novel vasodilator adrenomedullin in the rat. Endocrinology 136, 2127-2134
17. Poyner, D. R. (1997) Molecular pharmacology of receptors for calcitonin-gene-related peptide, amylin and adrenomedullin. Biochem. Soc. Trans. 25, 1032-1036
18. Dschietzig, T., Azad, H. A., Asswad, L., Bohme, C., Bartsch, C. and Baumann, G. (2002) The adrenomedullin receptor acts as clearance receptor in pulmonary circulation. Biochem. Biophys. Res. Commun. 294, 315-318
19. Qing, X., Svaren, J. and Keith, I. M. (2001) mRNA expression of novel CGRP1 receptors and their activity-modifying proteins in hypoxic rat lung. Am. J. Physiol. Lung Cell. Mol. Physiol. 280, L547-L554
20. Nagae, T., Mukoyama, M., Sugawara, A. et al. (2000) Rat receptor-activity-modifying proteins (RAMPs) for adrenomedullin/CGRP receptor: cloning and upregulation in obstructive nephropathy. Biochem. Biophys. Res. Commun. 270, 89-93
21. Hagner, S., Haberberger, R., Hay, D. L. et al. (2003) Immunohistochemical detection of the calcitonin receptor-like receptor protein in the microvasculature of rat endothelium. Eur. J. Pharmacol. 481, 147-151
22. Hagner, S., Stahl, U., Knoblauch, B., McGregor, G. P. and Lang, R. E. (2002) Calcitonin receptor-like receptor: identification and distribution in human peripheral tissues. Cell Tissue Res. 310, 41-50