Adrenomedullin is inactivated in the lungs of neonatal piglets

Journal of Pharmacy and Pharmacology

Volumn 48, Issue 6, 1996, Pages 578-580

  Sabates, Braulio ^a   Granger, Tommie ^a   Choe, Ella ^a   Pigott, John ^a   Lippton, Howard ^a   Hyman, Albert ^a   Flint, Lewis ^a   Ferrara, John ^a  

^a TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENOMEDULLIN;

ANIMAL EXPERIMENT; ARTERIAL PRESSURE; ARTICLE; CONTROLLED STUDY; HEART LEFT ATRIUM; HEART OUTPUT; HEART RIGHT ATRIUM; HYPOTENSION; LUNG; LUNG ARTERY PRESSURE; LUNG CIRCULATION; LUNG VASCULAR RESISTANCE; NEWBORN; NONHUMAN; PROTEIN METABOLISM; SWINE; SYSTEMIC VASCULAR RESISTANCE; VASODILATATION;

EID: 0030055436     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.2042-7158.1996.tb05977.x     Document Type: Article

References (8)

1. DeVito, M., Lippton, H., Hyman, A., Chang, J.-K., Choe, E., Flint, L., Ferrara, J. (1995) Vasoactive effects of adrenomedullin on neonatal piglet regional circulations. Pharm. Sci. 1: 325-328
2. Hao, Q., Chang, J.-K., Gharavi, H., Fortenberry, Y., Hyman, A., Lippton, H. (1994) An adrenomedullin (ADM) fragment retains the systemic vasodilator activity of human ADM. Pharmacol. Lett. 54: 265-270
3. Kitamura, K., Kangawa, K., Kawamoto, M., Ichiki, Y, Nakamura, S., Matsuo, H., Eto, T. (1993a) Adrenomedullin: a novel hypotensive peptide isolated from human pheochromocytoma. Biochem. Biophys. Res. Commun. 192(2): 553-560
4. Kitamura, K., Sakata, J., Kangawa, K., Kojima, M., Matsuo, H., Eto, T. (1993b) Cloning and characterization of cDNA encoding: a precursor for human adrenomedullin. Biochem. Biophys. Res. Commun. 194(2): 720-725
5. Kitamura, K., Kangawa, K., Kojima, M., Ichiki, Y., Matsuo, H., Eto, T. (1994) Complete amino acid sequence of porcine adrenomedullin and cloning of cDNA encoding its precursor. FEBS Lett. 338: 306-310
6. Lippton, H., Chang, J.-K., Hao, Q., Summer, W., Hyman, A. (1994) Adrenomedullin dilates the pulmonary vascular bed in vivo. J. Appl. Physiol. 76: 2154-2156
7. Perret, M., Broussard, H., LeGros, T., Burns, A., Chang, J.-K., Summer, W., Hyman, A., Lippton, H. (1993) The effect of adrenomedullin on the isolated heart. Life. Sci. 53: 377
8. Sakata, J., Shimokubo, T., Kitamura, K., Nakamura, S., Kangawa, K., Matsuo, H., Eto, T. (1993) Molecular cloning and biological activities of rat adrenomedullin, a hypotensive peptide. Biochem. Biophys. Res. Commun. 195(2): 921-927