The active molecular form of plasma adrenomedullin is extracted in the pulmonary circulation in patients with mitral stenosis: Possible role of adrenomedullin in pulmonary hypertension

Clinical Science

Volumn 100, Issue 1, 2001, Pages 61-66

  Nishikimi, T ^a   Nagata, S ^a   Sasaki, T ^a   Yoshihara, F ^a   Nagaya, N ^a   Horio, T ^a   Matsuo, H ^a   Matsuoka, H ^a   Kangawa, K ^a  

^a DOKKYO MEDICAL UNIVERSITY   (Japan)

Author keywords

Adrenomedullin; Mitral stenosis; Pulmonary circulation; Pulmonary hypertension

Indexed keywords

ADRENOMEDULLIN;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; FEMALE; HEART LEFT ATRIUM; HORMONAL REGULATION; HORMONE BLOOD LEVEL; HUMAN; IMMUNORADIOMETRIC ASSAY; LUNG ARTERY PRESSURE; LUNG CIRCULATION; LUNG VASCULAR RESISTANCE; MALE; MITRAL VALVE STENOSIS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PULMONARY ARTERY; PULMONARY HYPERTENSION;

ADRENOMEDULLIN; ADULT; AGED; BLOOD SPECIMEN COLLECTION; FEMALE; HEART CATHETERIZATION; HEMODYNAMIC PROCESSES; HUMANS; HYPERTENSION, PULMONARY; MALE; MIDDLE AGED; MITRAL VALVE STENOSIS; PEPTIDES; PULMONARY CIRCULATION;

EID: 0035181739     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/CS20000119     Document Type: Article

References (26)

1. Adrenomedullin: A novel hypotensive peptide isolated from human pheochromocytoma
2. Endothelial cells actively synthesize and secrete adrenomedullin
3. Production and secretion of adrenomedullin from vascular smooth muscle cells: Augmented production by tumor necrosis factor α
4. An abundant and specific binding site for the novel vasodilator adrenomedullin in the rat
5. AMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor
6. Adrenomedullin dilates the pulmonary vascular bed in vivo
7. Pulmonary vasodilation to adrenomedullin: A novel peptide in humans
8. Augmented adrenomedullin concentrations in right ventricle and plasma of experimental pulmonary hypertension
9. Plasma levels of adrenomedullin in primary and secondary pulmonary hypertension in patients < 20 years of age
10. Increased plasma levels of adrenomedullin in patients with pulmonary hypertension
11. Cloning and characterization of cDNA encoding a precursor for human adrenomedullin
12. The intermediate form of glycine - Extended adrenomedullin is the major circulating molecular form in human plasma
13. One-step direct assay for mature-type adrenomedullin with monoclonal antibodies
14. A simple immunoradiometric assay for measuring the entire molecules of adrenomedullin in human plasma
15. Rapid increase in plasma endothelin concentrations during percutaneous balloon dilatation of the mitral valve in patients with mitral stenosis
16. Rapid reduction of atrial natriuretic peptide levels during percutaneous transvenous mitral commissurotomy in patients with mitral stenosis
17. Left ventricular pressure-volume response immediately after successful percutaneous mitral commissurotomy
18. Relationship between left ventricular geometry acid natriuretic peptide levels in essential hypertension
19. Plasma levels of adrenomedullin in patients with mitral stenosis
20. Plasma concentrations of adrenomedullin correlate with the extent of pulmonary hypertension in patients with mitral stenosis
21. Secretion and clearance of the mature form of adrenomedullin in humans
22. Autoradiographic studies on the binding sites of 125I-adrenomedullin in rat tissues
23. Clinical studies on the sites of production and clearance of circulating adrenomedullin in human subjects
24. Synthetic human adrenomedullin and ADM15-M52 have potent short-lasting vasodilator activity in the pulmonary vascular bed of the cat
25. Pulmonary vasodilator responses to adrenomedullin are reduced by NOS inhibitors in rats but not in cats
26. Pulmonary vasodilator responses to adrenomedullin in patients with pulmonary hypertension