Delivery of plasmid DNA expressing small interference RNA for TGF-β type II receptor by cationized gelatin to prevent interstitial renal fibrosis

Journal of Controlled Release

Volumn 105, Issue 3, 2005, Pages 318-331

  Kushibiki, Toshihiro ^a   Nagata Nakajima, Natsuki ^b   Sugai, Manabu ^b   Shimizu, Akira ^b   Tabata, Yasuhiko ^a  

^a KYOTO UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY   (Japan)

Author keywords

Cationized gelatin; Gene delivery; Renal interstitial fibrosis; Small interference RNA (siRNA); Transforming growth factor (TGF ) receptor

Indexed keywords

BIOLOGICAL ORGANS; DISEASES; DNA; DRUG THERAPY; GELATION; GROWTH KINETICS; RNA;

EXTRACELLULAR MATRIX (ECM); FIBROTIC AREA; INTERSITIAL FIBROSIS; RENAL FAILURE;

CONTROLLED DRUG DELIVERY;

ALPHA SMOOTH MUSCLE ACTIN; COLLAGEN; GELATIN; MESSENGER RNA; PLASMID DNA; SMALL INTERFERING RNA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; DRUG EFFECT; FEASIBILITY STUDY; GENE EXPRESSION; HUMAN; HUMAN CELL; KIDNEY; KIDNEY FIBROSIS; MALE; MOUSE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; NONVIRAL GENE THERAPY; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA DEGRADATION; URETER; URETER OBSTRUCTION;

ANIMALS; BLOTTING, WESTERN; DNA; EXCIPIENTS; FIBROSIS; GELATIN; GENE EXPRESSION; KIDNEY; MICE; NEPHRITIS, INTERSTITIAL; PLASMIDS; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; RECOMBINANT PROTEINS; RNA, SMALL INTERFERING; TISSUE FIXATION;

EID: 21744440388     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2005.02.030     Document Type: Article

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