Single-stranded DNA condensed with poly-L-lysine results in nanometric particles that are significantly smaller, more stable in physiological ionic strength fluids and afford higher efficiency of gene delivery than their double-stranded counterparts

Biochimica et Biophysica Acta - General Subjects

Volumn 1572, Issue 1, 2002, Pages 37-44

  Molas, M ^a   Bartrons, R ^a   Perales, J C ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

Author keywords

Gene therapy; Nonviral gene transfer; Receptor mediated endocytosis; Single stranded DNA

Indexed keywords

ASIALOGLYCOPROTEIN RECEPTOR; DOUBLE STRANDED DNA; GALACTOSE; NUCLEIC ACID; POLYLYSINE; SINGLE STRANDED DNA; SODIUM CHLORIDE;

ARTICLE; CELL LINE; CHROMATIN CONDENSATION; CONTROLLED STUDY; DNA DETERMINATION; DNA VECTOR; ENDOCYTOSIS; EUKARYOTIC CELL; GENE TARGETING; GENETIC TRANSFECTION; HEPATOMA CELL; HUMAN; HUMAN CELL; IONIC STRENGTH; NONVIRAL GENE DELIVERY SYSTEM; PRIORITY JOURNAL; PROTEIN EXPRESSION;

DNA, SINGLE-STRANDED; FLOW CYTOMETRY; GENE EXPRESSION; GENE THERAPY; GENETIC VECTORS; MICROSCOPY, ELECTRON; NUCLEIC ACID DENATURATION; OSMOLAR CONCENTRATION; PARTICLE SIZE; POLYLYSINE; SOLUTIONS; TRANSFECTION;

EUKARYOTA;

EID: 0037104623     PISSN: 03044165     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-4165(02)00276-3     Document Type: Article

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