The molecular basis for coxib inhibition of p38α MAP kinase

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 15, 2005, Pages 3506-3509

  Sperandio Da Silva, Gilberto M ^a   Lima, Lidia M ^a   Fraga, Carlos A M ^a   Sant'Anna, Carlos M R ^a,b   Barreiro, Eliezer J ^a  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^b FEDERAL RURAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

Coxib; p38 MAPK inhibition

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; 4 [5 (4 BROMOPHENYL) 3 TRIFLUOROMETHYL 1H PYRAZOL 1 YL]BENZENESULFONAMIDE; CELECOXIB; ETORICOXIB; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; COMPARATIVE MOLECULAR FIELD ANALYSIS; DRUG BINDING; DRUG POTENCY; DRUG STRUCTURE; ENERGY; FEMALE; MOUSE; NONHUMAN;

ALGORITHMS; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; DATABASES, FACTUAL; ENZYME ACTIVATION; ENZYME INHIBITORS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PROTEIN BINDING; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 21744439429     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.05.107     Document Type: Article

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