A novel 3D-QSAR comparative molecular field analysis (CoMFA) model of imidazole and quinazolinone functionalized p38 MAP kinase inhibitors

Bioorganic and Medicinal Chemistry

Volumn 12, Issue 12, 2004, Pages 3159-3166

  Sperandio Da Silva, Gilberto M ^a   Sant'Anna, Carlos M R ^a,b   Barreiro, Eliezer J ^a  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^b FEDERAL RURAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

CoMFA model; dihydroquinazolinone; p38 Inhibitors; Tetrasubstituted imidazole compounds

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; DQO 501; IMIDAZOLE DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE P38; QUINAZOLINONE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; COMPARATIVE MOLECULAR FIELD ANALYSIS; ENZYME ACTIVITY; ENZYME INHIBITION; GENETIC ALGORITHM; LINEAR REGRESSION ANALYSIS; MOLECULAR MODEL; QUANTITATIVE STRUCTURE ACTIVITY RELATION;

ENZYME INHIBITORS; IMIDAZOLES; INHIBITORY CONCENTRATION 50; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR STRUCTURE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; QUINAZOLINES; REPRODUCIBILITY OF RESULTS;

EID: 2542479010     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2004.04.004     Document Type: Article

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