Inhibitory effect of imipramine on the human corticotropin-releasing- hormone gene promoter activity operates through a PI3-K/AKT mediated pathway

Neuropharmacology

Volumn 49, Issue 2, 2005, Pages 156-164

  Basta Kaim, Agnieszka ^a   Budziszewska, Bogusława ^a   Jaworska Feil, Lucylla ^a   Tetich, Magdalena ^a   Kubera, Marta ^a   Leśkiewicz, Monika ^a   Lasoń, Władysław ^a  

^a INSTITUTE OF PHARMACOLOGY   (Poland)

Author keywords

Differentiated Neuro 2A cells; hCRH gene promoter activity; Imipramine; Protein kinases; Stable transfection

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ADENOSINE 3',5' PHOSPHOROTHIOATE; ADENYLATE CYCLASE ACTIVATOR; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; CHLORAMPHENICOL ACETYLTRANSFERASE; CORTICOTROPIN RELEASING FACTOR; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; FORSKOLIN; GLYCOGEN SYNTHASE KINASE 3BETA; IMIPRAMINE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; N (4 AMINOBUTYL) 5 CHLORO 2 NAPSYLAMIDE; PHORBOL 13 ACETATE 12 MYRISTATE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOTRANSFERASE INHIBITOR; PROTEIN KINASE (CALCIUM,CALMODULIN); PROTEIN KINASE B; WORTMANNIN;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL STRAIN; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME INHIBITION; GENE ACTIVITY; GENETIC TRANSFECTION; INHIBITION KINETICS; INTRACELLULAR SPACE; MOUSE; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; REPORTER GENE; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ADRENERGIC UPTAKE INHIBITORS; ANIMALS; BLOTTING, WESTERN; CELL LINE, TUMOR; CHLORAMPHENICOL O-ACETYLTRANSFERASE; CORTICOTROPIN-RELEASING HORMONE; ENZYME ACTIVATION; ENZYME INHIBITORS; FORSKOLIN; GENE EXPRESSION REGULATION; HUMANS; IMIPRAMINE; MICE; NEUROBLASTOMA; PLASMIDS; PROMOTER REGIONS (GENETICS); PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; TRANSFECTION;

EID: 21644475248     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2005.02.008     Document Type: Article

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