Application of simple mathematical expressions to relate the half-lives of xenobiotics in rats to values in humans

Journal of Pharmacological and Toxicological Methods

Volumn 51, Issue 1, 2005, Pages 57-64

  Ward, Keith W ^a   Erhardt, Paul ^b   Bachmann, Kenneth ^c  

^a GLAXOSMITHKLINE   (United States)

^b UNIVERSITY OF TOLEDO   (United States)

^c MEDICAL COLLEGE OF OHIO   (United States)

Author keywords

Half life; Human; Methods; Rat; Xenobiotic

Indexed keywords

2 FLUOROSPIRO[FLUORENE 9,4' IMIDAZOLIDINE] 2',5' DIONE; 6 (1 METHYL 1,2,3 TRIAZOL 4 YLMETHYLENE)PENEM 3 CARBOXYLIC ACID; ACETYLSALICYLIC ACID; ACICLOVIR; ACIVICIN; ACTISOMIDE; ALFENTANIL; AMIFLOXACIN; AMIODARONE; AMITRIPTYLINE; AMOBARBITAL; AMOXICILLIN; AMPHOTERICIN B; APROBARBITAL; AZTREONAM; BETAMIPRON; BIAPENEM; BRODIFACOUM; CAPTOPRIL; CEFADROXIL; CEFAZOLIN; CEFCLIDIN; CEFEPIME; CEFMETAZOLE; IMIRESTAT; MEPIRODIPINE; PARACETAMOL; PHENAZONE; UNINDEXED DRUG; XENOBIOTIC AGENT;

ALGORITHM; ARTICLE; CONTROLLED STUDY; DRUG HALF LIFE; HUMAN; LIVER BLOOD FLOW; MATHEMATICAL ANALYSIS; NONHUMAN; PREDICTION; RAT; SPECIES COMPARISON; ANIMAL; CHEMISTRY; COMPARATIVE STUDY; HALF LIFE TIME; INFORMATION PROCESSING; LIVER; MATHEMATICS; PREDICTION AND FORECASTING; STATISTICS; TOXICITY TESTING; VASCULARIZATION;

ALGORITHMS; ANIMALS; DATA COLLECTION; HALF-LIFE; HUMANS; LIVER; MATHEMATICS; PREDICTIVE VALUE OF TESTS; RATS; STATISTICS; TOXICITY TESTS; XENOBIOTICS;

EID: 21644467788     PISSN: 10568719     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vascn.2004.07.004     Document Type: Article

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