If phosphatidylserine is the death knell, a new phosphatidylserine-specific receptor is the bellringer

Cell Death and Differentiation

Volumn 8, Issue 6, 2001, Pages 582-587

  Fadok, V A ^a   Xue, D ^b   Henson, P ^a  

^a NATIONAL JEWISH MEDICAL AND RESEARCH CENTER   (United States)

^b UNIVERSITY OF COLORADO   (United States)

Author keywords

Apoptosis; Cytokines; Phagocytosis; Phosphatidylserine; Receptor

Indexed keywords

ANTIINFLAMMATORY AGENT; CELL RECEPTOR; IMMUNOGLOBULIN M; LIGAND; LIPOSOME; MONOCLONAL ANTIBODY; PHOSPHATIDYLSERINE; PHOSPHATIDYLSERINE RECEPTOR; PHOSPHOLIPID; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

ADHESION; ANIMAL CELL; APOPTOSIS; CAENORHABDITIS ELEGANS; CELL DEATH; CELL TYPE; CLEARANCE; CONTROLLED STUDY; DROSOPHILA MELANOGASTER; GENE; HUMAN; HUMAN CELL; MAMMAL; MOLECULAR RECOGNITION; MOUSE; NONHUMAN; PHAGOCYTE; PHAGOCYTOSIS; PRIORITY JOURNAL; REVIEW; SEQUENCE HOMOLOGY; STIMULATION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; APOPTOSIS; HUMANS; INVERTEBRATES; MAMMALS; PHAGOCYTOSIS; PHOSPHATIDYLSERINES; RECEPTORS, CELL SURFACE;

ANIMALIA; CAENORHABDITIS ELEGANS; DROSOPHILA MELANOGASTER; MAMMALIA; MELANOGASTER;

EID: 0034949428     PISSN: 13509047     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cdd.4400856     Document Type: Review

References (72)

1. Loss of phospholipid asymmetry and surface exposure of phosphatidylserine is required for phagocytosis of apoptotic cells by macrophages and fibroblasts
2. The clearance of apoptotic cells in the liver is mediated by the asialoglycoprotein receptor
3. Phagocytosis of apoptotic bodies by liver endothelial cells
4. Endothelial liver cell recognition of apoptotic peripheral blood lymphocytes
5. Macrophage recognition of cells undergoing programmed cell death (apoptosis)
6. Human Kupffer cell recognition and phagocytosis of apoptotic peripheral blood lymphocytes
7. Vitronectin receptor-mediated phagocytosis of cells undergoing apoptosis
8. Macrophage vitronectin receptor, CD36, and thrombospondin cooperate in recognition of neutrophils undergoing programmed cell death
9. Recognition of phosphatidylserine on the surface of apoptotic spermatogenic cells and subsequent phagocytosis by Sertoli cells of the rat
10. Role of class B scavenger receptor type I in phagocytosis of apoptotic rat spermatogenic cells by Sertoli cells
11. Role for the class A macrophage scavenger receptor in the phagocytosis of apoptotic thymocytes in vitro
12. Recognition of oxidatively damaged and apoptotic cells by an oxidized low density lipoprotein receptor on mouse peritoneal macrophages: Role of membrane phosphatidylserine
13. Independent mechanisms for macrophage binding and macrophage phagocytosis of damaged erythrocytes. Evidence of receptor cooperativity
14. Lectin-like oxidized low-density lipoprotein receptor 1 mediates phagocytosis of aged/apoptotic cells in endothelial cells
15. Human CD14 mediates recognition and phagocytosis of apoptotic cells
16. Recognition of apoptotic cells by human macrophages: Inhibition by a monocyte/macrophage-specific monoclonal antibody
17. Complement-dependent clearance of apoptotic cells by human macrophages
18. A novel beta 1 integrin-dependent mechanism of leukocyte adherence to apoptotic cells
19. A hierarchical role for classical pathway complement proteins in the clearance of apoptotic cells in vivo
20. Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies
21. Immune clearance of phosphatidylserine-expressing cells by phagocytes. The role of beta2-glycoprotein I in macrophage recognition
22. Characterization of phosphatidylserine-dependent beta2-glycoprotein I macrophage interactions. Implications for apoptotic cell clearance by phagocytes
23. Consequences of cell death: Exposure to necrotic tumor cells, but not primary tissue cells or apoptotic cells, induces the maturation of immunostimulatory dendritic cells
24. A receptor for phosphatidylserine-specific clearance of apoptotic cells
25. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro
26. Different populations of macrophages use either the vitronectin receptor or the phosphatidylserine receptor to recognize and remove apoptotic cells
27. Particle digestibility is required for induction of the phosphatidylserine recognition mechanism used by murine macrophages to phagocytose apoptotic cells
28. CD36 is required for phagocytosis of apoptotic cells by human macrophages that use either a phosphatidylserine receptor or the vitronectin receptor (alpha v beta 3)
29. Multiple systems for recognition of apoptotic lymphocytes by macrophages
30. Exposure of phosphatidylserine is a general feature in the phagocytosis of apoptotic lymphocytes by macrophages
31. Surface expression of phosphatidylserine on macrophages is required for phagocytosis of apoptotic thymocytes
32. Function of WW domains as phosphoserine- or phosphothreonine-binding modules
33. A novel phosphatidylserine binding peptide motif defined by an anti-idiotypic monoclonal antibody. Localization of phosphatidylserine-specific binding sites on protein kinase C and phosphatidylserine decarboxylase
34. Placental anticoagulant proteins: Isolation and comparative characterization four members of the lipocortin family
35. Primary structure of human placental anticoagulant protein
36. Human placental anticoagulant protein: Isolation and characterization
37. Clustering of lipid-bound annexin V may explain its anticoagulant effect
38. Binding of vascular anticoagulant alpha (VAC alpha) to planar phospholipid bilayers
39. Isolation and partial purification of a novel anticoagulant from arteries of human umbilical cord
40. Phospholipid binding of annexin V: Effects of calcium and membrane phosphatidylserine content
41. Interaction of placental anticoagulant protein-I (lipocortin V) with model membranes
42. Phospholipid binding properties of human placental anticoagulant protein-l, a member of the lipocortin family
43. Membrane and lipid involvement in blood coagulation
44. Interaction between terminal complement proteins C5b-7 and anionic phospholipids
45. Characterization of the ligand binding activities of vitronectin: Interaction of vitronectin with lipids and identification of the binding domains for various ligands using recombinant domains
46. Activation of the alternative pathway of complement by calcium-loaded erythrocytes resulting from loss of membrane phospholipid asymmetry
47. Recognition and clearance of liposomes containing phosphatidylserine are mediated by serum opsonin
48. Activation of the alternative complement pathway by exposure of phosphatidylethanolamine and phosphatidylserine on erythrocytes from sickle cell disease patients
49. Phagocytosis of apoptotic neutrophils does not induce macrophage release of thromboxane B2
50. Human monocyte-derived macrophage phagocytosis of senescent eosinophils undergoing apoptosis. Mediation by alpha v beta 3/CD36/thrombospondin recognition mechanism and lack of phlogistic response
51. Human glomerular mesangial cell phagocytosis of apoptotic neutrophils: Mediation by a novel CD36-independent vitronectin receptor/thrombospondin recognition that is uncoupled from chemokine secretion
52. Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF
53. Transcriptional and translational regulation of inflammatory mediator production by endogenous TGFb in macrophages that have ingested apoptotic cells
54. Immunosuppressive effects of apoptotic cells
55. Phosphatidylserine exposure by apoptotic cells is phylogenetically conserved
56. Candidate adaptor protein CED-6 promotes the engulfment of apoptotic cells in C. elegans
57. Human CED-6 encodes a functional homologue of the Caenorhabditis elegans engulfment protein CED-6
58. The C. elegans cell corpse engulfment gene ced-7 encodes a protein similar to ABC transporters
59. C. elegans phagocytosis and cell-migration protein CED-5 is similar to human DOCK 180
60. CED-2/Crkll and CED-10/Rac control phagocytosis and cell migration in Caenorhabditis elegans
61. ABC1 promotes engulfment of apoptotic cells and transbilayer redistribution of phosphatidylserine
62. Engulfment of apoptotic cells involves the redistribution of membrane phosphatidylserine on phagocyte and prey
63. The ATP binding cassette transporter ABC1, is required for the engulfment of corpses generated by apoptotic cell death
64. Identification and characterization of a dimerization domain in CED-6, an adapter protein involved in engulfment of apoptotic cells
65. The human homologue of Caenorthabditis elegans CED-6 specifically promotes phagocytosis of apoptotic cells
66. Alphavbeta5 integrin recruits the Crkll-Dock180-rac1 complex for phagocytosis of apoptotic cells
67. The molecular mechanism of programmed cell death in C. elegans
68. Cell death in C. elegans: Molecular insights into mechanisms conserved between nematodes and mammals
69. Genes required for the engulfment of cell corpses during programmed cell death in Caenorhabditis elegans
70. Croquemort, a novel Drosophila hemocyte/macrophage receptor that recognizes apoptotic cells
71. Requirement for croquemort in phagocytosis of apoptotic cells in Drosophila
72. CED-1 is a transmembrane receptor that mediates cell corpse engulfment in C. elegans