Molecular determinants of cardiac KATP channel activation by epoxyeicosatrienoic acids

Journal of Biological Chemistry

Volumn 280, Issue 19, 2005, Pages 19097-19104

  Lu, Tong ^a   Hong, Min Pyo ^a   Lee, Hon Chi ^a  

^a MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ENERGY; ALCOHOLS; ENZYMES; METABOLITES; ORGANIC ACIDS;

CHANNEL SENSITIVITY; EPOXYEICOSATRIENOIC ACIDS (EET); EPOXYGENAASE METABOLITES; MOLECULAR DETERMINANTS;

CARDIOLOGY;

11,12 EPOXY 5,8,14 ICOSATRIENOIC ACID; 14,15 EPOXY 5,8,11 ICOSATRIENOIC ACID; 8,9 EPOXYICOSATRIENOIC ACID; ADENOSINE TRIPHOSPHATE; ALANINE; ARGININE; CYTOCHROME P450 EPOXYGENASE; CYTOCHROME P450 ISOENZYME; EPOXYICOSATRIENOIC ACID; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR6.2; LYSINE; MUTANT PROTEIN; POTASSIUM CHANNEL; PROTEIN SUBUNIT; SULFONYLUREA DERIVATIVE; UNCLASSIFIED DRUG; 11,12 EPOXY 5,8,14 EICOSATRIENOIC ACID; 11,12-EPOXY-5,8,14-EICOSATRIENOIC ACID; 8,9-EPOXYEICOSATRIENOIC ACID; ABC TRANSPORTER; ARACHIDONIC ACID; DIHOMO GAMMA LINOLENIC ACID; DRUG DERIVATIVE; DRUG RECEPTOR; INWARDLY RECTIFYING POTASSIUM CHANNEL; SULFONYLUREA RECEPTOR; VASODILATOR AGENT;

ALLOSTERISM; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CELL STRAIN HEK293; CHANNEL GATING; COMPUTER MODEL; HUMAN; HUMAN CELL; IC 50; MOLECULAR INTERACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; STEREOSPECIFICITY; ANIMAL; CELL LINE; CHEMICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; COMPUTER PROGRAM; ELECTROPHYSIOLOGY; GENE DELETION; METABOLISM; MOUSE; MUTATION; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; SITE DIRECTED MUTAGENESIS;

8,11,14-EICOSATRIENOIC ACID; ADENOSINE TRIPHOSPHATE; ALLOSTERIC SITE; ANIMALS; ARACHIDONIC ACID; ATP-BINDING CASSETTE TRANSPORTERS; BINDING SITES; CELL LINE; ELECTROPHYSIOLOGY; GENE DELETION; HUMANS; INHIBITORY CONCENTRATION 50; MICE; MODELS, CHEMICAL; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; MUTATION; POTASSIUM CHANNELS; POTASSIUM CHANNELS, INWARDLY RECTIFYING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, DRUG; SOFTWARE; VASODILATOR AGENTS;

EID: 21444460965     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M414065200     Document Type: Article

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