Are antimicrobial peptides an alternative for conventional antibiotics?

Nuclear Medicine Review

Volumn 8, Issue 1, 2005, Pages 78-86

  Kamysz, Wojciech ^a  

^a MEDICAL UNIVERSITY OF GDANSK   (Poland)

Author keywords

Antimicrobial peptides; Peptide antibiotics

Indexed keywords

ANTIBIOTIC AGENT; BACITRACIN; BACTENECIN; BACTERIOCIN; BOMBININ; CATHELICIDIN; CECROPIN; CIPROFLOXACIN; COLICIN; DAPTOMYCIN; DEFENSIN; HELIOMYCIN; IB 367; INDOLICIDIN; ISEGANAN; LACTOFERRICIN B; LACTOFERRIN; LANTIBIOTIC; MAGAININ DERIVATIVE; MELITTIN; NISIN; PEXIGANAN ACETATE; POLYMYXIN B; POLYPEPTIDE ANTIBIOTIC AGENT; PR 39; PROTEGRIN; RECOMBINANT BACTERICIDAL PERMEABILITY INCREASING PROTEIN; SARALASIN; TECHNETIUM 99M; VANCOMYCIN;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ANTIFUNGAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIPROTOZOAL ACTIVITY; ANTIVIRAL ACTIVITY; BACTERIAL INFECTION; CELL PROLIFERATION; CLINICAL TRIAL; DRUG ACCUMULATION; DRUG EFFICACY; DRUG HALF LIFE; DRUG ISOLATION; DRUG RETENTION; DRUG SELECTIVITY; DRUG STRUCTURE; EPIDEMIC MENINGITIS; EUKARYOTE; GRAM NEGATIVE INFECTION; HUMAN; IMMUNOSTIMULATION; INNATE IMMUNITY; ISOTOPE LABELING; MUCOSA INFLAMMATION; NONHUMAN; PEPTIDE SYNTHESIS; REVIEW; SCINTIGRAPHY; SEPSIS; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTI-BACTERIAL AGENTS; ANTI-INFECTIVE AGENTS; ANTIMICROBIAL CATIONIC PEPTIDES; BACTERIOCINS; DRUG DESIGN; DRUG INDUSTRY; HUMANS; MODELS, CHEMICAL; PATENTS; PEPTIDES;

EID: 21444454572     PISSN: 15069680     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (93)

1. Weidenmaier C, Kristian SA, Peschel A. Bacterial resistance to antimicrobial host defenses - an emerging target for novel antiinfective strategies? Curr Drug Targets 2003; 4: 643-649.
2. Ganz T, Lehrer RI. Antimicrobial peptides of vertebrates. Curr Opin Immunol 1998; 10: 41-44.
3. Tossi A, Sandri L. Molecular diversity in gene-encoded, cationic anti-microbial polypeptides. Curr Pharm Des 2002; 8: 743-761.
4. Riley MA, Wertz JE. Bacteriocin diversity: ecological and evolutionary perspectives. Biochimie 2002; 84: 357-364.
5. Moll GN, Konings WN, Driessen AJ. Bacteriocins: mechanism of membrane insertion and pore formation. Antonie Van Leeuwenhoek 1999; 76: 185-198.
6. Braun V, Patzer SI, Hantke K. Ton-dependent colicins and microcins: modular design and evolution. Biochimie 2002; 84: 365-380.
7. Cleveland J, Montville TJ, Nes IF, Chikindas ML. Bacteriocins: safe, natural antimicrobials for food preservation. Int J Food Microbiol 2001; 71: 1-20.
8. http://www.bbcm.univ.trieste.it/~tossi/pag1.htm.
9. http://aps.unmc.edu/AP/main.html.
10. Csordas A, Michl H. Isolation and structural resolution of a haemolytically active polypeptide from the immune secretion of a European toad. Monatsh Chem 1970: 101: 182-189.
11. Habermann E. Bee and wasp venoms. Science 1972; 177: 314-322.
12. Asthana N, Yadav SP, Ghosh JK. Dissection of antibacterial and toxic activity of melittin: A leucine zipper motif plays crucial role in determining its hemolytic activity but not antibacterial activity. J Biol Chem 2004 (paper in press).
13. Steiner H, Hultmark D, Engstrom A, Bennich H, Boman HG. Sequence and specificity of two antibacterial proteins involved in insect immunity. Nature 1981; 292: 246-248.
14. Zasloff M. Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor. Proc Natl Acad Sci USA 1987; 84: 5449-5453.
15. Jacob L, Zasloff M. Potential therapeutic applications of magainins and other antimicrobial agents of animal origin. Ciba Found Symp 1994; 186: 197-216.
16. Otvos L Jr. Antibacterial peptides isolated from insects. J Pept Sci 2000; 6: 497-511.
17. Conlon JM, Kolodziejek J, Nowotny N. Antimicrobial peptides from ranid frogs: taxonomic and phylogenetic markers and a potential source of new therapeutic agents. Biochim Biophys Acta 2004; 1696: 1-14.
18. Sugiarto H, Yu PL. Avian antimicrobial peptides: the defense role of β-defensins. Biochem Biophys Res Commun. 2004; 323: 721-727.
19. Noga EJ, Silphaduang U. Piscidins: a novel family of peptide antibiotics from fish. Drug News Perspect 2003; 16: 87-92.
20. Sima P, Trebichavsky I, Sigler K. Mammalian antibiotic peptides Folia Microbiol (Praha). 2003; 48: 123-137.
21. Hoffmann JA, Hetru C, Reichhart JM. The humoral antibacterial response of Drosophila. FEBS Lett 1993; 325: 63-66.
22. Meister M, Lemaitre B, Hoffmann JA. Antimicrobial peptide defense in Drosophila. Bioessays. 1997; 19: 1019-1026.
23. Ganz T. Defensins: antimicrobial peptides of innate immunity. Nat Rev Immunol 2003; 3: 710-720.
24. Kamysz W, Okrój M, Łukasiak J. Novel properties of antimicrobial peptides. Acta Biochim Pol 2003; 50: 461-469.
25. Faurschou M, Sorensen OE, Johnsen AH, Askaa J, Borregaard N. Defensin-rich granules of human neutrophils: characterization of secretory properties. Biochim Biophys Acta 2002; 1591: 29-35.
26. Ayabe T, Ashida T, Kohgo Y, Kono T. The role of Paneth cells and their antimicrobial peptides in innate host defense. Trends Microbiol 2004; 12: 394-398.
27. Selsted ME, Tang YQ, Morris WL et al. Purification, primary structures, and antibacterial activities of beta-defensins, a new family of antimicrobial peptides from bovine neutrophils. J Biol Chem 1993; 268: 6641-6648.
28. Cole AM, Waring AJ. The role of defensins in lung biology and therapy. Am J Respir Med 2002; 1: 249-259.
29. Evans EW, Beach GG, Wunderlich J, Harmon BG. Isolation of antimicrobial peptides from avian heterophils. J Leukoc Biol 1994; 56: 661-665.
30. Ramanathan B, Davis EG, Ross CR, Blecha F. Cathelicidins: microbicidal activity, mechanisms of action, and roles in innate immunity. Microbes Infect 2002; 4: 361-372.
31. Gudmundsson GH. Agerberth B. Neutrophil antibacterial peptides, multifunctional effector molecules in the mammalian immune system. J Immunol Methods 1999; 232: 45-54.
32. Nagaoka I, Hirota S, Niyonsaba F et al. Cathelicidin family of antibacterial peptides CAP18 and CAP11 inhibit the expression of TNF-α by blocking the binding of LPS to CD14 (+) cells. J Immunol 2001; 167: 3329-3338.
33. Bellm L, Lehrer RI, Ganz T. Protegrins: new antibiotics of mammalian origin. Expert Opin Investig Drugs 2000; 9: 1731-1742.
34. Gennaro R, Skerlavaj B, Romeo D. Purification, composition, and activity of two bactenecins, antibacterial peptides of bovine neutrophils. Infect Immun 1989; 57: 3142-3146.
35. Selsted ME, Novotny MJ, Morris WL et al. Indolicidin, a novel bactericidal tridecapeptide amide from neutrophils. J Biol Chem 1992; 267: 4292-4295.
36. Zanetti M, Litteri L, Gennaro R, Horstmann H, Romeo D. Bactenecins, defense polypeptides of bovine neutrophils, are generated from precursor molecules stored in the large granules. J Cell Biol 1990; 111: 1363-1371.
37. Panyutich A, Shi J, Boutz PL, Zhao C, Ganz T. Porcine polymorphonuclear leukocytes generate extracellular microbicidal activity by elastase-mediated activation of secreted proprotegrins. Infect Immun 1997; 65: 978-985.
38. Koradi R, Billeter M, Wuthrich K. MOLMOL: a program for display and analysis of macromolecular structures. J Mol Graph 1996; 14: 51-55.
39. Simmaco M, Mignogna G, Barra D, Bossa F. Antimicrobial peptides from skin secretions of Rana esculenta. Molecular cloning of cDNAs encoding esculentin and brevinins and isolation of new active peptides. J Biol Chem 1994; 269: 11956-11961.
40. Zhang XL, Selsted ME, Pardi A. NMR studies of defensin antimicrobial peptides. 1. Resonance assignment and secondary structure determination of rabbit NP-2 and human HNP-1. Biochemistry 1992; 31: 11348-11356.
41. Oppenheim FG, Xu T, McMillian FM. Histatins, a novel family of histidine-rich proteins in human parotid secretion. Isolation, characterization, primary structure, and fungistatic effects on Candida albicans. J Biol Chem 1998; 263: 7472-7477.
42. Simmaco M, Mignogna G, Canofeni S et al. Temporins, antimicrobial peptides from the European red frog Rana temporaria. Eur J Biochem 1996; 242: 788-792.
43. Hwang PM, ZhouN, Shan X, Arrowsmith CH, Vogel HJ. Three-dimensional solution structure of lactoferricin B, an antimicrobial peptide derived from bovine lactoferrin. Biochemistry 1998; 37: 4288-4298.
44. Bobek LA, Situ H MUC7 20-Mer: Investigation of Antimicrobial Activity, Secondary Structure, and Possible Mechanism of Antifungal Action. Antimicrob Agents Chemother 2003; 47: 643-652.
45. Leuschner C, Hansel W. Membrane disrupting lytic peptides for cancer treatments. Curr Pharm Des 2004; 10: 2299-2310.
46. Huang HW. Action of antimicrobial peptides: two-state model. Biochemistry 2000; 39: 8347-8352.
47. Ding L, Yang L, Weiss TM et al. Interaction of antimicrobial peptides with lipopolysaccharides. Biochemistry 2003; 42: 12251-1229.
48. Park CB, Kim HS, Kim SC. Mechanism of action of the antimicrobial peptide buforin II: buforin II kills microorganisms by penetrating the cell membrane and inhibiting cellular functions. Biochem Biophys Res Commun 1998; 244: 253-257.
49. Carlsson A, Nystrom T, de Cock H, Bennich H. Attacin - an insect immune protein - binds LPS and triggers the specific inhibition of bacterial outer-membrane protein synthesis. Microbiology 1998; 144: 2179-2188.
50. Boman HG, Agerberth B, Boman A. Mechanisms of action on Escherichia coli of cecropin P1 and PR-39, two antibacterial peptides from pig intestine. Infect Immun 1993; 61: 2978-2984.
51. Hamamoto K, Shimizu T, Kida Y, Kuwano K. Interactions of a small linear cationic peptide with lipopolysaccharide and lipoteichoic acid. Kurume Med J 2003; 50: 99-107.
52. Hack CE, Aarden LA, Thijs LG. Role of cytokines in sepsis. Adv Immunol 1997; 66: 101-195.
53. Lupetti A, Danesl R, van 't Wout JW et al. Antimicrobial peptides: therapeutic potential for the treatment of Candida infections. Expert Opin Investig Drugs 2002; 11: 309-318.
54. Edgerton M, Koshlukova SE, Araujo MW et al. Salivary histatin 5 and human neutrophil defensin 1 kill Candida albicans via shared pathways. Antimicrob Agents Chemother 2000; 44: 3310-3316.
55. Cole AM. Minidefensins and other antimicrobial peptides: candidate anti-HIV microbicides. Expert Opin Ther Targets 2003; 7: 329-341.
56. Yasin B, Pang M, Turner JS et al. Evaluation of the inactivation of infectious Herpes simplex virus by host-defense peptides. Eur J Clin Microbiol Infect Dis 2000; 19: 187-194.
57. Huang CM, Chen HC, Zierdt CH. Magainin analogs effective against pathogenic protozoa. Antimicrob Agents Chemother 1990; 34: 1824-1826.
58. Shin SY, Kang JH, Hahm KS. Structure-antibacterial, antitumor and hemolytic activity relationships of cecropin A-magainin 2 and cecropin A-melittin hybrid peptides. J Pept Res 1999; 53: 82-90.
59. Matsuzaki K, Sugishita K, Fujii N, Miyajima K. Molecular basis for membrane selectivity of an antimicrobial peptide, magainin 2. Biochemistry 1995; 34: 3423-3429.
60. Murphy CJ, Foster BA, Mannis MJ, Selsted ME, Reid TW. Defensins are mitogenic for epithelial cells and fibroblasts. J Cell Physiol 1993; 155: 408-413.
61. Charp PA, Rice WG, Raynor RL et al. Inhibition of protein kinase C by defensins, antibiotic peptides from human neutrophils. Biochem Pharmacol 1988; 37: 951-956.
62. Tanaka K, Fujimoto Y, Suzuki M et al. PI3-kinase p85alpha is a target molecule of proline-rich antimicrobial peptide to suppress proliferation of ras-transformed cells. Jpn J Cancer Res 2001; 92: 959-967.
63. Territo MC, Ganz T, Selsted ME, Lehrer R. Monocyte-chemotactic activity of defensins from human neutrophils. J Clin Invest 1989; 84: 2017-2020.
64. Chaly YV, Paleolog EM, Kolesnikova TS et al. Neutrophil alpha-defensin human neutrophil peptide modulates cytokine production in human monocytes and adhesion molecule expression in endothelial cells. Eur Cytokine Netw 2000; 11: 257-266.
65. Braunstein A, Papo N, Shai Y. In vitro activity and potency of an intravenously injected antimicrobial peptide and its DL amino acid analog in mice infected with bacteria. Antimicrob Agents Chemother 2004; 48: 3127-3129.
66. Ge Y, MacDonald D, Henry MM et al. In vitro susceptibility to pexiganan of bacteria isolated from infected diabetic foot ulcers. Diagn Microbiol Infect Dis 1999; 35: 45-53.
67. Rothstein DM, Spacciapoli P, Tran LT et al. Anticandida activity is retained in P-113, a 12-amino-acid fragment of histatin. Antimicrob Agents Chemother 2001; 45: 1367-1373.
68. Mosca DA, Hurst MA, So W et al. IB-367, a protegrin peptide with in vitro and in vivo activities against the microflora associated with oral mucositis. Antimicrob Agents Chemother 2000; 44: 1803-1808.
69. Mannis MJ. The use of antimicrobial peptides in ophthalmology: an experimental study in corneal preservation and the management of bacterial keratitis. Trans Am Ophthalmol Soc 2002; 100: 243-271.
70. Clara A, Manjramkar DD, Reddy VK. Preclinical evaluation of magainin-A as a contraceptive antimicrobial agent. Fertil Steril 2004; 81: 1357-1365.
71. Jerala R, Porro M. Endotoxin neutralizing peptides. Curr Top Med Chem 2004; 4: 1173-1184.
72. Riedl P, Reimann J, Schirmbeck R. Peptides containing antigenic and cationic domains have enhanced, multivalent immunogenicity when bound to DNA vaccines. J Mol Med 2004; 82: 144-152.
73. Balaban N, Gov Y, Giacometti A et al. A chimeric peptide composed of a dermaseptin derivative and an RNA III-inhibiting peptide prevents graft-associated infections by antibiotic-resistant staphylococci. Antimicrob Agents Chemother 2004; 48: 2544-2550.
74. Kamysz W, Greber K, Turecka K, Łukasiak J., Okrój. The effect of temporin A and their retro-analogue on aerobic bacteria. Polish J Cosm 2004; 3: 204-208.
75. Appendini P, Hotchkiss JH. Antimicrobial activity of a 14-residue synthetic peptide against foodborne microorganisms. J Food Prot 2000; 63: 889-893.
76. Gao AG, Hakimi SM, Mittanck CA et al. Fungal pathogen protection in potato by expression of a plant defensin peptide. Nat Biotechnol 2000; 18: 1307-1310.
77. Welling MM, Paulusma-Annema A, Balter HS, Pauwels EK, Nibbering PH. Technetium-99m labelled antimicrobial peptides discriminate between bacterial infections and sterile inflammations. Eur J Nucl Med 2000; 27: 292-301.
78. Lauta VM. Pharmacological elements in clinical application of synthetic peptides. Fundam Clin Pharmacol 2000; 14: 425-442.
79. Sader HS, Fedler KA, Rennie RP, Stevens S, Jones RN. Omiganan pentahydrochloride (MBI 226), a topical 12-amino-acid cationic peptide: spectrum of antimicrobial activity and measurements of bactericidal activity. Antimicrob Agents Chemother 2004; 48: 3112-3118.
80. Zasloff M. Antimicrobial peptides of multicellular organisms. Nature 2002; 415: 389-395.
81. Gratz S, Rennen HJ, Boerman OC et al. 99mTc-HMPAO-labeled autologous versus heterologous leukocytes for imaging infection. J Nucl Med 2002; 43: 918-924.
82. Annovazzi A, Biancone L, Caviglia R et al. 99mTc-interleukin-2 and (99m)Tc-HMPAO granulocyte scintigraphy in patients with inactive Crohn's disease. Eur J Nucl Med Mol Imaging 2003; 30: 374-382.
83. Rennen HJ, Boerman OC, Oyen WJ, van der Meer JW, Corstens FH. Specific and rapid scintigraphic detection of infection with 99mTc-labeled interleukin-8. J Nucl Med 2001; 42: 117-123.
84. Calame W, Welling M, Feitsma HI, Goedemans WT, Pauwels EK. Contribution of phagocytic cells and bacteria to the accumulation of technetium-99m labelled polyclonal human immunoglobulin at sites of inflammation. Eur J Nucl Med 1995; 22: 638-644.
85. Kinne RW, Becker W, Schwab J et al. Imaging rheumatoid arthritis joints with technetium-99m labelled specific anti-CD4- and non-specific monoclonal antibodies. Eur J Nucl Med 1994; 21: 176-180.
86. Sundram FX, Wong WY, Ang ES et al. Evaluation of technetium-99m ciprofloxacin (Infecton) in the imaging of infection. Ann Acad Med Singapore 2000; 29: 699-703.
87. Vallabhajosula S. Technetium-99m-labeled chemotactic peptides: specific for imaging infection? J Nucl Med 1997; 38: 1322-1326.
88. Welling MM, Nibbering PH, Paulusma-Annema A et al. Imaging of bacterial infections with 99mTc-labeled human neutrophil peptide-1. J Nucl Med 1999; 40: 2073-2080.
89. Bleeker-Rovers CP, Boerman OC, Rennen HJ, Corstens FH, Oyen WJ. Radiolabeled compounds in diagnosis of infectious and inflammatory disease. Curr Pharm Des 2004; 10: 2935-2950.
90. Welling MM, Lupetti A, Balter HS et al. 99mTc-labeled antimicrobial peptides for detection of bacterial and Candida albicans infections. J Nucl Med 2001; 42: 788-794.
91. Welling MM, Paulusma-Annema A, Balter HS, Pauwels EK, Nibbering PH. Technetium-99m labelled antimicrobial peptides discriminate between bacterial infections and sterile inflammations. Eur J Nucl Med 2000; 27: 292-301.
92. Nibbering PH, Ravensbergen E, Welling MM et al. Human lactoferrin and peptides derived from its N terminus are highly effective against infections with antibiotic-resistant bacteria. Infect Immun 2001; 69: 1469-1476.
93. Andersson L, Blomberg L, Flegel M et al. Large-scale synthesis of peptides. Biopolymers 2000; 55: 227-250.