Rat duodenal IRPI activity and iron absorption in iron deficiency and after H2O2 perfusion

European Journal of Clinical Investigation

Volumn 34, Issue 4, 2004, Pages 275-282

  Schumann K ^a,e   Brennan, K ^b   Weiss, M ^d   Pantopoulos, K ^c   Hentze, M W ^b  

^a Lehrst F Ernahrungsphysiologie TUM   (Germany)

^b EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^c MCGILL UNIVERSITY   (Canada)

^d UNIVERSITY OF MUNICH   (Germany)

^e TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

Absorption; Duodenum; Iron; IRP1; Oxidative stress

Indexed keywords

GLUCOSE; HYDROGEN PEROXIDE; IRON; IRON 59; IRON REGULATORY PROTEIN 1; WATER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DUODENUM; DUODENUM MUCOSA; EX VIVO STUDY; GEL MOBILITY SHIFT ASSAY; GLUCOSE TRANSPORT; IN VIVO STUDY; INJURY; INTESTINE PERFUSION; INTESTINE VILLUS; IRON ABSORPTION; IRON DEFICIENCY; IRON TRANSPORT; LIGATION; MALE; MEASUREMENT; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; RAT; STIMULATION; TIME; WATER TRANSPORT; ABSORPTION; ANIMAL; DOSE RESPONSE; DRUG EFFECT; INTESTINE MUCOSA; METABOLISM; METHODOLOGY; OXIDATIVE STRESS; PATHOLOGY; PERFUSION; PHYSIOLOGY; SPRAGUE DAWLEY RAT; STOMACH; STOMACH LAVAGE;

ABSORPTION; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; DUODENUM; GASTRIC LAVAGE; HYDROGEN PEROXIDE; INTESTINAL MUCOSA; IRON; IRON REGULATORY PROTEIN 1; MALE; OXIDATIVE STRESS; PERFUSION; RATS; RATS, SPRAGUE-DAWLEY; STOMACH;

EID: 2142717374     PISSN: 00142972     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2362.2004.01335.x     Document Type: Article

References (34)

1. Ponka P, Beaumont C, Richardson DR. Function and regulation of transferrin and ferritin. Seminars Hematol 1998;35:35-54.
2. Hentze MW, Kühn LC. Molecular control of vertebrate iron metabolism: mRNA-based regulatory circuits operated by iron, nitric oxide and ozidative stress. Proc Natl Acad Sci USA 1996;93:8175-82.
3. Eisenstein RS. Iron regulatory proteins and the molecular control of mammalian iron metabolism. Annu Rev Nutr 2000;20:627-62.
4. Johansson HE, Theil EC. Iron-response element (IRE) structure and combinatorial RNA regulation. In: Templeton DM, editor. Molecular and Cellular Iron Transport. New York, Basel: Marcel Dekker Inc;2002,pp. 237-53.
5. Pantopoulos K, Hentze MW. Nitric oxide, oxygen radicals and iron metabolism. In: Ignarro L, editor. Nitric Oxide. San Diego, CA: Academic Press;2000,pp. 293-313.
6. Cairo G, Pietrangelo A. Iron regulatory proteins in pathobiology. Biochem J 2000;352:241-50.
7. Martins EA, Robalinho RL, Meneghini R. Oxidative stress induces activation of a cytosolic protein responsible for control of iron uptake. Arch Biochem Biophys 1995;316:128-34.
8. Pantopoulos K, Hentze MW. Rapid responses to oxidative stress mediated by iron regulatory protein. EMBO J 1995;14:2917-24.
9. 2) control mammalian iron metabolism by different pathways. Mol Cell Biol 1996;16:3781-8.
10. Pantopoulos K, Mueller S, Atzberger A, Ansorge W, Stremmel W, Hentze MW. Differences in the regulation of iron regulatory protein 1 (IRP1) by extra- and intracellular oxidative stress. J Biol Chem 1997;272:9802-8.
11. Pantopoulos K, Hentze MW. Activation of iron regulatory protein-1 by oxidative stress in vitro. Proc Natl Acad Sci USA 1998;95:10559-63.
12. 2 on the expression and function of iron-responsive element-containing mRNAs in B6 fibroblasts. J Biol Chem 2001;76:19738-45.
13. Mueller S, Pantopoulos K, Hübner C, Stremmel W, Hentze MW. IRP1 activation by extracellular oxidative stress in the perfused rat liver. J Biol Chem 2001;276:23192-6.
14. Fleming MD, Trenor CCI, Su MA, Foernzler D, Beier DR, Dietrich WF et al. Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene. Nature Genet 1997;16:383-6.
15. Gunshin H, Mackenzie B, Berger UV, Gunshin Y, Romero MF, Boron WF et al. Cloning and characterization of a mammalian protein-coupled metal-ion transporter. Nature 1997;388:482-8.
16. Donovan A, Brownlie A, Zhou Y, Shepard J, Pratt SJ, Moynihan J et al. Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter. Nature 2000;403:776-81.
17. McKie AT, Marciani P, Rolfs A, Brennan K, Wehr K, Barrow D et al. A novel duodenal iron-regulated transporter IREG1, implicated in the basolateral transfer of iron to the circulation. Mol Cell 2000;5:299-309.
18. Abboud S, Haile DJ. A novel mammalian iron-regulated protein involved in intracellular iron metabolism. J Biol Chem 2000;275:19906-12.
19. Schümann K, Moret R, Künzle H, Kühn LC. Iron regulatory protein as an endogenous sensor of iron in rat intestinal mucosa. Possible implications for the regulation of iron absorption. Eur J Biochem 1999;260:362-72.
20. Roy CN, Enns CA. Iron homeostasis: new tales from the crypt. Blood 2000;96:4020-7.
21. Anderson GJ, Powell LW, Halliday JW. The endocytosis of transferrin by rat intestinal epithelial cells. Gastroenterology 1994;106:414-22.
22. Oates PS, Morgan EH. Effects of dietary iron loading with carbonyl iron and of iron depletion on intestinal growth, morphology, and expression of transferrin receptor in the rat. Anat Rec 1996;246:364-71.
23. Schümann K, Elsenhans B, Hunder G, Strugala G, Forth W. Increase of the intestinal iron absorption in growing rats and mice after 8 days of iron-deficient feeding. Z Versuchstierkd 1989;32:261-7.
24. Hentze MW, Rouault TA, Harford JB, Klausner RD. Oxidation-reduction and the molecular mechanism of a regulatory RNA-protein interaction. Science 1989;244:357-9.
25. Bahram S, Gilfillan S, Kühn LC, Moret R, Schulze JB, Lebeau A et al. Experimental hemochromatosis due to MHC class I HFE deficiency: immune status and iron metabolism. Proc Natl Acad Sci USA 1999;96:13312-7.
26. Schümann K, Elsenhans B, Ehtechami C, Forth W. Rat intestinal iron transfer capacity and the longitudinal distribution of its adaptation to iron deficiency. Digestion 1990;46:35-45.
27. 59Fe movement across the intestinal wall in duodenal rat segments ex vivo. Am J Physiol 1999;276:G431-G440.
28. Zoller H, Theurl I, Koch R, Kaser A, Weiss G. Mechanisms of iron mediated regulation of the duodenal iron transporters divalent metal transporter 1 and ferroportin 1. Blood Cells Mol Dis 2002;29:488-97.
29. Tchernitchko D, Bourgeois M, Martin ME, Beaumont C. Expression of the two mRNA isoforms of the iron transporter Nramp2/DMT1 in mice and function of the iron responsive element. Biochem J 2002;363:449-55.
30. Brazzolotto X, Gaillard J, Pantopoulos K, Hentze MW, Moulis J-M. Human cytoplasmic aconitase (iron regulatory protein 1) is converted into its [3Fe-4S] form by hydrogen peroxide in vitro, but is not activated for iron responsive element-binding. J Biol Chem 1999;274:21625-30.
31. King IS, Paterson JY, Peacock MA, Smith MW, Syme G. Effect of diet upon enterocyte differentiation in the rat jejunum. J Physiol 1983;344:465-81.
32. O'Riordan DK, Debnam ES, Sharp PA, Simpson RJ, Taylor EM, Srai SK. Mechanisms involved in increased iron uptake across rat duodenal brush-border membrane during hypoxia. J Physiol 1997;500:379-84.
33. Eastwood GL. Gastrointestinal epithelial renewal. Gastroenterology 1977;72:962-75.
34. LaVaute T, Smith S, Cooperman S, Iwai K, Land W, Meyron-Holtz E et al. Targeted deletion of the gene encoding iron regulatory protein-2 causes disregulation of iron metabolism and neurodegenerative disease in mice. Nat Genet;27:209-14.