Mechanisms involved in increased iron uptake across rat duodenal brush-border membrane during hypoxia

Journal of Physiology

Volumn 500, Issue 2, 1997, Pages 379-384

  O'Riordan, Donagh K ^a   Debnam, Edward S ^a   Sharp, Paul A ^a   Simpson, Robert J ^b   Taylor, Eve M ^b   Srai, Surjit K S ^a  

^a ROYAL FREE HOSPITAL   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

IRON; SODIUM ION;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; CELL MATURATION; CELL MEMBRANE POTENTIAL; CONTROLLED STUDY; DEPOLARIZATION; DUODENUM; HYPERPOLARIZATION; HYPOXIA; INTESTINE BRUSH BORDER MEMBRANE; INTESTINE CELL; INTESTINE VILLUS; IRON TRANSPORT; MALE; MEMBRANE PERMEABILITY; MICROELECTRODE; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0030900009     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1113/jphysiol.1997.sp022028     Document Type: Article

References (21)

1. CHOWRIMOOTOO, G., DEBNAM, E. S., SRAI, S. K. S. & EPSTEIN, O. (1992a). Regional characteristics of intestinal iron absorption in the guinea pig. Experimental Physiology 77, 177-183.
2. CHOWRIMOOTOO, G., GILLETT, M., DEBNAM, E. S., SRAI, S. K. & EPSTEIN, O. (1992b). Iron-transferrin binding to isolated guinea pig enterocytes and the regional localisation of intestinal iron transfer during ontogeny. Biochimica et Biophysica Acta 1116, 256-260.
3. CONRAD, M. E., UMBREIT, J. N. & MOORE, E. G. (1993). Rat duodenal iron-binding protein mobilferrin is a homologue of calreticulin. Gastroenterology 104, 1700-1704.
4. COX, T. M. & O'DONNELL, M. W. (1981). Studies on the binding of iron by rabbit intestinal microvillus membranes. Biochemical Journal 194, 753-759.
5. COX, T. M. & PETERS, T. J. (1980). In vitro studies of duodenal iron uptake in patients with primary and secondary iron storage disease. Quarterly Journal of Medicine 49, 249-257.
6. DEBNAM, E. S., SRAI, S. K. S., CHOWRIMOOTOO, G. & EPSTEIN, O. (1991). Ontogeny of iron uptake across brush border membrane of guinea pig duodenum and its autoradiographic localisation. Biology of the Neonate 59, 30-36.
7. DEBNAM, E. S. & THOMPSON, C. S. (1984). The effect of fasting on the potential difference across the brush border membrane of enterocytes in rat small intestine. Journal of Physiology 355, 449-456.
8. +-dependent sugar transport by isolated intestinal cells: evidence for a major role for membrane potentials. American Journal of Physiology 233, E357-362.
9. KOZMA, M. M., CHOWRIMOOTOO, G., DEBNAM, E. S., EPSTEIN, O. & SRAI, S. K. S. (1994). Developmental changes in enterocyte iron binding proteins in the guinea pig. Expression of transferrin, H and L ferritin and binding of iron to a low molecular weight protein. Biochimica et Biophysica Acta 1201, 229-234.
10. OKADA, Y., IRIMAJIRI, A. & INOUYE, A. (1976). Permeability properties and intracellular ion concentrations of epithelial cells in rat duodenum. Biochimica et Biophysica Acta 436, 15-24.
11. OKADA, Y., SATO, T. & INOUYE, A. (1975). Effects of potassium ions and sodium ions on membrane potential of epithelial cells in rat duodenum. Biochimica et Biophysica Acta 413, 104-115.
12. O'RIORDAN, D. K., SHARP, P. A., EPSTEIN, O., SRAI, S. K. S. & DEBNAM, E. S. (1995a). Rats fed an iron deficient diet have enhanced intestinal iron transfer and hyperpolarization of the duodenal brush-border membrane. Journal of Physiology 482.P, 29-30P.
13. O'RIORDAN, D. K., SHARP, P. A., SYKES, R. M., SRAI, S. K., EPSTEIN, O. & DEBNAM, E. S. (1995b). Cellular mechanisms underlying the increased duodenal iron absorption in rats in response to phenylhydrazine-induced haemolytic anaemia. European Journal of Clinical Investigation 25, 722-727.
14. O'RIORDAN, D. K., SIMPSON, R. J., SHARP, P. A., DEBNAM, E. S. & SRAI, S. K. S. (1996). Positional changes in iron transport across brush border of isolated rat duodenum following 3 days hypoxia. Journal of Physiology 494.P, 56-57P.
15. O'RIORDAN, D. K., SIMPSON, R. J., TAYLOR, E., SHARP, P. A., DEBNAM, E. S. & SRAI, S. K. S. (1995c). Hypoxia causes hyperpolarization of isolated rat duodenal brush-border membrane and increased iron absorption. Journal of Physiology 489.P, 124P.
16. OSTERLOH, K. R., SIMPSON, R. J., SNAPE, S. & PETERS, T. J. (1987). Intestinal iron absorption and mucosal transferrin in rats subjected to hypoxia. Blut 55, 421-431.
17. RAJA, K. B., SIMPSON, R. J. & PETERS, T. J. (1989). Membrane potential dependence of Fe(III) uptake by mouse duodenum. Biochimica et Biophysica Acta 984, 262-266.
18. REYNAFARJE, C. & RAMOS, J. (1961). Influence of altitude changes on intestinal iron absorption. Journal of Laboratory and Clinical Medicine 57, 848-855.
19. SMITH, M. W. (1985). Expression of digestive and absorptive function in differentiating enterocytes. Annual Review of Physiology 47, 247-260.
20. SNAPE, S., SIMPSON, R. J. & PETERS, T. J. (1990). Subcellular localisation of recently absorbed iron in mouse duodenal enterocytes: identification of a basolateral membrane iron-binding site. Cell Biochemistry and Function 8, 107-115.
21. TAYLOR, E. M., RAJA, K. B., SIMPSON, R. J. & PETERS, T. J. (1997). Modulation of duodenal iron uptake by hypoxia and fasting in the rat. British Journal of Nutrition (in the Press).