Cultured human adult microglia from different donors display stable cytokine, chemokine and growth factor gene profiles but respond differently to a pro-inflammatory stimulus

NeuroImmunoModulation

Volumn 12, Issue 4, 2005, Pages 235-245

  Meeuwsen, Sonja ^a   Bsibsi, Malika ^a   Persoon Deen, Carla ^a   Ravid, Rivka ^b   Van Noort, Johannes M ^a  

^a TNO   (Netherlands)

^b NETHERLANDS BRAIN BANK   (Netherlands)

Author keywords

Chemokines; Cytokines; Gene expression profiling; Growth factor; Microglia

Indexed keywords

CHEMOKINE; COMPLEMENTARY DNA; CORTICOTROPIN RELEASING FACTOR RECEPTOR 1; CYTOKINE; ENDOTHELIN 2; FLT3 LIGAND; GAMMA INTERFERON; GROWTH FACTOR; MIGRATION INHIBITION FACTOR; NEUROMODULIN; THYMOSIN BETA10; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CELL CULTURE; COMPARATIVE STUDY; CONTROLLED STUDY; DNA MICROARRAY; GENE EXPRESSION; HUMAN; HUMAN CELL; MICROGLIA; PRIORITY JOURNAL; STIMULUS RESPONSE;

AGED; AGED, 80 AND OVER; CELLS, CULTURED; CHEMOKINES; CYTOKINES; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GROWTH SUBSTANCES; HUMANS; INFLAMMATION MEDIATORS; INTERFERON TYPE II; MALE; MICROGLIA; MIDDLE AGED; NEUROIMMUNOMODULATION; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RNA, MESSENGER; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION; VARIATION (GENETICS);

EID: 21344457222     PISSN: 10217401     EISSN: None     Source Type: Journal    
DOI: 10.1159/000085655     Document Type: Article

References (73)

1. Perry VH, Gordon S: Macrophages and microglia in the nervous system. Trends Neurosci 1988;11:273-277.
2. Perry VH, Gordon S: Macrophages and the nervous system. Int Rev Cytol 1991;125:203-244.
3. Santambrogio L, Belyanskaya SL, Fischer FR, Cipriani B, Brosnan CF, Ricciardi-Castagnoli P, Stern LJ, Strominger JL, Riese R: Developmental plasticity of CNS microglia. Proc Natl Acad Sci USA 2001;98:6295-6300.
4. Hayes GM, Woodroofe MN, Cuzner ML: Characterisation of microglia isolated from adult human and rat brain. J Neuroimmunol 1988;19:177-189.
5. Kreutzberg GW: Microglia, the first line of defence in brain pathologies. Arzneimittelforschung 1995;45:357-360.
6. Hickey WF, Kimura H: Perivascular microglial cells of the CNS are bone marrow-derived and present antigen in vivo. Science 1988;239:290-292.
7. Amat JA, Ishiguro H, Nakamura K, Norton WT: Phenotypic diversity and kinetics of proliferating microglia and astrocytes following cortical stab wounds. Glia 1996;16:368-382.
8. Streit WJ, Walter SA, Pennell NA: Reactive microgliosis. Prog Neurobiol 1999;57:563-581.
9. Streit WJ, Graeber MB: Heterogeneity of microglial and perivascular cell populations: Insights gained from the facial nucleus paradigm. Glia 1993;7:68-74.
10. Nelson PT, Soma LA, Lavi E: Microglia in diseases of the central nervous system. Ann Med 2002;34:491-500.
11. Akiyama H, Tooyama I, Kondo H, Ikeda K, Kimura H, McGeer EG, McGeer PL: Early response of brain resident microglia to kainic acid-induced hippocampal lesions. Brain Res 1994;635:257-268.
12. Peterson PK, Hu S, Salak-Johnson J, Molitor TW, Chao CC: Differential production of and migratory response to beta chemokines by human microglia and astrocytes. J Infect Dis 1997;175:478-481.
13. Hayes GM, Woodroofe MN, Cuzner ML: Microglia are the major cell type expressing MHC class II in human white matter. J Neurol Sci 1987;80:25-37.
14. Haga S, Akai K, Ishii T: Demonstration of microglial cells in and around senile (neuritic) plaques in the Alzheimer brain. An immunohistochemical study using a novel monoclonal antibody. Acta Neuropathol (Berl) 1989;77:569-575.
15. McGeer PL, Itagaki S, Boyes BE, McGeer EG: Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains. Neurology 1988;38:1285-1291.
16. Kolson DL, Lavi E, Gonzalez-Scarano F: The effects of human immunodeficiency virus in the central nervous system. Adv Virus Res 1998;50:1-47.
17. Kreutzberg GW: Microglia: A sensor for pathological events in the CNS. Trends Neurosci 1996;19:312-318.
18. Meeuwsen S, Persoon-Deen C, Bsibsi M, Ravid R, Noort JM: Cytokine, chemokine and growth factor gene profiling of cultured human astrocytes after exposure to proinflammatory stimuli. Glia 2003;43:243-253.
19. Bajramovic JJ, Bsibsi M, Geutskens SB, Hassankhan R, Verhulst KC, Stege GJ, De Groot CJ, van Noort JM: Differential expression of stress proteins in human adult astrocytes in response to cytokines. J Neuroimmunol 2000;106:14-22.
20. De Groot CJ, Langeveld CH, Jongenelen CA, Montagne L, van der Valk P, Dijkstra CD: Establishment of human adult astrocyte cultures derived from postmortem multiple sclerosis and control brain and spinal cord regions: Immunophenotypical and functional characterization. J Neurosci Res 1997;49:342-354.
21. Suzumura A, Sawada M, Yamamoto H, Marunouchi T: Effects of colony stimulating factors on isolated microglia in vitro. J Neuroimmunol 1990;30:111-120.
22. Lee SC, Liu W, Brosnan CF, Dickson DW: GM-CSF promotes proliferation of human fetal and adult microglia in primary cultures. Glia 1994;12:309-318.
23. Hulette CM, Downey BT, Burger PC: Macrophage markers in diagnostic neuropathology. Am J Surg Pathol 1992;16:493-499.
24. Schluesener HJ, Kremsner PG, Meyermann R: Widespread expression of MRP8 and MRP14 in human cerebral malaria by microglial cells. Acta Neuropathol (Berl) 1998;96:575-580.
25. Engel S, Schluesener H, Mittelbronn M, Seid K, Adjodah D, Wehner HD, Meyermann R: Dynamics of microglial activation after human traumatic brain injury are revealed by delayed expression of macrophage-related proteins MRP8 and MRP14. Acta Neuropathol (Berl) 2000;100:313-322.
26. Mehler MF, Mabie PC, Zhang D, Kessler JA: Bone morphogenetic proteins in the nervous system. Trends Neurosci 1997;20:309-317.
27. Li YS, Gurrieri M, Deuel TF: Pleiotrophin gene expression is highly restricted and is regulated by platelet-derived growth factor. Biochem Biophys Res Commun 1992;184:427-432.
28. Radulovic M, Spiess J: Immunomodulatory role of the corticotropin- releasing factor. Arch Immunol Ther Exp (Warsz) 2001;49:33-38.
29. Sameshima T, Nabeshima K, Toole BP, Yokogami K, Okada Y, Goya T, Koono M, Wakisaka S: Expression of emmprin (CD147), a cell surface inducer of matrix metalloproteinases, in normal human brain and gliomas. Int J Cancer 2000;88:21-27.
30. Giaid A, Gibson SJ, Herrero MT, Gentleman S, Legon S, Yanagisawa M, Masaki T, Ibrahim NB, Roberts GW, Rossi ML: Topographical localisation of endothelin mRNA and peptide immunoreactivity in neurones of the human brain. Histochemistry 1991;95:303-314.
31. Neve RL, Perrone-Bizzozero NI, Finklestein S, Zwiers H, Bird E, Kurnit DM, Benowitz LI: The neuronal growth-associated protein GAP43 (B-50, F1): Neuronal specificity, developmental regulation and regional distribution of the human and rat mRNAs. Brain Res 1987;388:177-183.
32. Li H, Cai Y, Xu J: Localization of a FLT3 ligand isoform in human tissues (in Chinese). Zhonghua Xue Ye Xue Za Zhi 1999;20:285-287.
33. Mansson R, Tsapogas P, Akerlund M, Lagergren A, Gisler R, Sigvardsson M: Pearson correlation analysis of microarray data allows for the identification of genetic targets for early B-cell factor. J Biol Chem 2004;279:17905-17913.
34. Mittelbronn M, Dietz K, Schluesener HJ, Meyermann R: Local distribution of microglia in the normal adult human central nervous system differs by up to one order of magnitude. Acta Neuropathol (Berl) 2001;101:249-255.
35. Abe M, Umehara F, Kubota R, Moritoyo T, Izumo S, Osame M: Activation of macrophages/microglia with the calcium-binding proteins MRP14 and MRP8 is related to the lesional activities in the spinal cord of HTLVI associated myelopathy. J Neurol 1999;246:358-364.
36. Broderick C, Hoek RM, Forrester JV, Liversidge J, Sedgwick JD, Dick AD: Constitutive retinal CD200 expression regulates resident microglia and activation state of inflammatory cells during experimental autoimmune uveoretinitis. Am J Pathol 2002;161:1669-1677.
37. Kohro T, Nakajima T, Wada Y, Sugiyama A, Ishii M, Tsutsumi S, Aburatani H, Imoto I, Inazawa J, Hamakubo T, Kodama T, Emi M: Genomic structure and mapping of human orphan receptor LXR alpha: Upregulation of LXRa mRNA during monocyte to macrophage differentiation. J Atheroscler Thromb 2000;7:145-151.
38. Re F, Belyanskaya SL, Riese RJ, Cipriani B, Fischer FR, Granucci F, Ricciardi-Castagnoli P, Brosnan C, Stern LJ, Strominger JL, Santambrogio L: Granulocyte-macrophage colony-stimulating factor induces an expression program in neonatal microglia that primes them for antigen presentation. J Immunol 2002;169:2264-2273.
39. Hua LL, Lee SC: Distinct patterns of stimulus-inducible chemokine mRNA accumulation in human fetal astrocytes and microglia. Glia 2000;30:74-81.
40. Paglinawan R, Malipiero U, Schlapbach R, Frei K, Reith W, Fontana A: TGFβ directs gene expression of activated microglia to an anti-inflammatory phenotype strongly focusing on chemokine genes and cell migratory genes. Glia 2003;44:219-231.
41. Carson MJ, Thrash JC, Lo D: Analysis of microglial gene expression: Identifying targets for CNS neurodegenerative and autoimmune disease. Am J Pharmacogenomics 2004;4:321-330.
42. Schmid CD, Sautkulis LN, Danielson PE, Cooper J, Hasel KW, Hilbush BS, Sutcliffe JG, Carson MJ: Heterogeneous expression of the triggering receptor expressed on myeloid cells-2 on adult murine microglia. J Neurochem 2002;83:1309-1320.
43. Walker DG, Lue LF, Beach TG: Gene expression profiling of amyloid beta peptide-stimulated human post-mortem brain microglia. Neurobiol Aging 2001;22:957-966.
44. Elkabes S, DiCicco-Bloom EM, Black IB: Brain microglia/macrophages express neurotrophins that selectively regulate microglial proliferation and function. J Neurosci 1996;16:2508-2521.
45. Wu CH, Chien HF, Chang CY, Ling EA: Heterogeneity of antigen expression and lectin labeling on microglial cells in the olfactory bulb of adult rats. Neurosci Res 1997;28:67-75.
46. Ren L, Lubrich B, Biber K, Gebicke-Haerter PJ: Differential expression of inflammatory mediators in rat microglia cultured from different brain regions. Brain Res Mol Brain Res 1999;65:198-205.
47. Giralt M, Carrasco J, Penkowa M, Morcillo MA, Santamaria J, Campbell IL, Hidalgo J: Astrocyte-targeted expression of interleukin-3 and interferon-alpha causes region-specific changes in metallothionein expression in the brain. Exp Neurol 2001;168:334-346.
48. Xie Z, Morgan TE, Rozovsky I, Finch CE: Aging and glial responses to lipopolysaccharide in vitro: Greater induction of IL-1 and IL-6, but smaller induction of neurotoxicity. Exp Neurol 2003;182:135-141.
49. Kim WG, Mohney RP, Wilson B, Jeohn GH, Liu B, Hong JS: Regional difference in susceptibility to lipopolysaccharide-induced neurotoxicity in the rat brain: Role of microglia. J Neurosci 2000;20:6309-6316.
50. Ma L, Morton AJ, Nicholson LF: Microglia density decreases with age in a mouse model of Huntington's disease. Glia 2003;43:274-280.
51. Dalmau I, Finsen B, Zimmer J, Gonzalez B, Castellano B: Development of microglia in the postnatal rat hippocampus. Hippocampus 1998;8:458-474.
52. Lacy M, Jones J, Whittemore SR, Haviland DL, Wetsel RA, Barnum SR: Expression of the receptors for the C5a anaphylatoxin, interleukin-8 and FMLP by human astrocytes and microglia. J Neuroimmunol 1995;61:71-78.
53. Flynn G, Maru S, Loughlin J, Romero IA, Male D: Regulation of chemokine receptor expression in human microglia and astrocytes. J Neuroimmunol 2003;136:84-93.
54. Albright AV, Shieh JT, Itoh T, Lee B, Pleasure D, O'Connor MJ, Doms RW, Gonzalez-Scarano F: Microglia express CCR5, CXCR4, and CCR3, but of these, CCR5 is the principal coreceptor for human immunodeficiency virus type 1 dementia isolates. J Virol 1999;73:205-213.
55. Rezaie P, Trillo-Pazos G, Everall IP, Male DK: Expression of beta-chemokines and chemokine receptors in human fetal astrocyte and microglial co-cultures: Potential role of chemokines in the developing CNS. Glia 2002;37:64-75.
56. De Groot CJ, Woodroofe MN: The role of chemokines and chemokine receptors in CNS inflammation. Prog Brain Res 2001;132:533-544.
57. Xia MQ, Qin SX, Wu LJ, Mackay CR, Hyman BT: Immunohistochemical study of the beta-chemokine receptors CCR3 and CCR5 and their ligands in normal and Alzheimer's disease brains. Am J Pathol 1998;153:31-37.
58. Lee SC, Liu W, Dickson DW, Brosnan CF, Berman JW: Cytokine production by human fetal microglia and astrocytes. Differential induction by lipopolysaccharide and IL-1 beta. J Immunol 1993;150:2659-2667.
59. Walker DG, Kim SU, McGeer PL: Complement and cytokine gene expression in cultured microglial derived from postmortem human brains. J Neurosci Res 1995;40:478-493.
60. 3 isoforms and TGF-β type I and type II receptors in multiple sclerosis lesions and human adult astrocyte cultures. J Neuropathol Exp Neurol 1999;58:174-187.
61. Griffin WS, Stanley LC, Ling C, White L, MacLeod V, Perrot LJ, White CL, Araoz C: Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease. Proc Natl Acad Sci USA 1989;86:7611-7615.
62. Matsuo A, Walker DG, Terai K, McGeer PL: Expression of CD43 in human microglia and its downregulation in Alzheimer's disease. J Neuroimmunol 1996;71:81-86.
63. Ehrlich LC, Hu S, Sheng WS, Sutton RL, Rockswold GL, Peterson PK, Chao CC: Cytokine regulation of human microglial cell IL-8 production. J Immunol 1998;160:1944-1948.
64. D'Aversa TG, Weidenheim KM, Berman JW: CD40-CD40L interactions induce chemokine expression by human microglia: Implications for human immunodeficiency virus encephalitis and multiple sclerosis. Am J Pathol 2002;160:559-567.
65. Peterson PK, Hu S, Salak-Johnson J, Molitor TW, Chao CC: Differential production of and migratory response to beta chemokines by human microglia and astrocytes. J Infect Dis 1997;175:478-481.
66. He J, Chen Y, Farzan M, Choe H, Ohagen A, Gartner S, Busciglio J, Yang X, Hofmann W, Newman W, Mackay CR, Sodroski J, Gabuzda D: CCR3 and CCR5 are co-receptors for HIV-1 infection of microglia. Nature 1997;385:645-649.
67. Hatori K, Nagai A, Heisel R, Ryu TK, Kim SU: Fractalkine and fractalkine receptors in human neurons and glial cells. J Neurosci Res 2002;69:418-426.
68. Lee SC, Liu W, Roth P, Dickson DW, Berman JW, Brosnan CF: Macrophage colony-stimulating factor in human fetal astrocytes and microglia. Differential regulation by cytokines and lipopolysaccharide, and modulation of class II MHC on microglia. J Immunol 1993;150:594-604.
69. Lee YB, Nagai A, Kim SU: Cytokines, chemokines, and cytokine receptors in human microglia. J Neurosci Res 2002;69:94-103.
70. Lee YB, Satoh J, Walker DG, Kim SU: Interleukin-15 gene expression in human astrocytes and microglia in culture. Neuroreport 1996;7:1062-1066.
71. Zhao ML, Si Q, Lee SC: IL-16 expression in lymphocytes and microglia in HIV-1 encephalitis. Neuropathol Appl Neurobiol 2004;30:233-242.
72. Janabi N, Mirshahi A, Wolfrom C, Mirshahi M, Tardieu M: Effect of interferon gamma and TNF alpha on the differentiation/activation of human glial cells: Implication for the TNF alpha receptor 1. Res Virol 1996;147:147-153.
73. Reali C, Curto M, Sogos V, Scintu F, Pauly S, Schwarz H, Gremo F: Expression of CD1 37 and its ligand in human neurons, astrocytes, and microglia: Modulation by FGF-2. J Neurosci Res 2003;74:67-73.