Regulation of AUF1 expression via conserved alternatively spliced elements in the 3' untranslated region

Molecular and Cellular Biology

Volumn 19, Issue 6, 1999, Pages 4056-4064

  Wilson, Gerald M ^a   Sun, Yue ^a   Sellers, Jeremy ^a   Lu, Haiping ^a   Penkar, Nameeta ^a   Dillard, Gwynn ^a   Brewer, Gary ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALTERNATIVE RNA SPLICING; ARTICLE; BINDING SITE; DOWN REGULATION; ERYTHROLEUKEMIA CELL; EXON; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE MAPPING; HUMAN; HUMAN CELL; INTRON; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RNA BINDING; STRUCTURE ANALYSIS;

EID: 0033012032     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.19.6.4056     Document Type: Article

References (51)

1. Aharon, T., and R. J. Schneider. 1993. Selective destabilization of short-lived mRNAs with the granulocyte-macrophage colony-stimulating factor AU-rich 3′ noncoding region is mediated by a cotranslational mechanism. Mol. Cell. Biol. 13:1971-1980.
2. Alfonso-Pizzaro, A., D. P. Carlson, and J. Ross. 1984, Subcellular localization of RNAs in transfected cells: role of sequences at the 5′ terminus. Nucleic Acids Res. 12:8363-8380.
3. Altschul, S. F., T. L. Madden, A. A. Schäfer, J. Zhang, Z. Zhang, W. Miller, and D. J. Lipman. 1997. Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res. 25:3389-3402.
4. Atwater, J. A., R. Wisdom, and I. M. Verma. 1990. Regulated mRNA stability. Annu. Rev. Genet. 24:519-541.
5. Brewer, G. 1991. An A+U-rich element RNA-binding factor regulates c-myc mRNA stability in vitro. Mol. Cell. Biol. 11:2460-2466.
6. Brewer, G. 1994. Post-transcriptional considerations of gene expression: translation, mRNA stability, and poly(A) processing, p. 40-59. In J. A. Wolff (ed.), Gene therapeutics. Birkhäuser Boston, Cambridge, Mass.
7. Brewer, G., and J. Ross. 1990. Messenger RNA turnover in cell-free extracts. Methods Enzymol. 181:202-209.
8. Brown, C. Y., C. A. Lagnado, and G. J. Goodall. 1996. A cytokine mRNA-destabilizing element that is structurally and functionally distinct from A+U-rich elements. Proc. Natl. Acad. Sci. USA 93:13721-13725.
9. Buzby, J. S., S. Lee, P. van Winkle, C. T. DeMaria, G. Brewer, and M. S. Cairo. 1996. Increased granulocyte-macrophage colony-stimulating factor mRNA instability in cord versus adult mononuclear cells is translation-dependent and associated with increased levels of A+U-rich element binding factor. Blood 88:2889-2897.
10. Chen, C.-Y. A., and A.-B. Shyu. 1995. AU-rich elements: characterization and importance in mRNA degradation. Trends Biochem. Sci. 20:465-470.
11. Cui, Y., K. W. Hagan, S. Zhang, and S. W. Peltz. 1995. Identification and characterization of genes that are required for the accelerated degradation of mRNAs containing a premature translational termination codon. Genes Dev. 9:423-436.
12. Curatola, A. M., M. S. Nadal, and R. J. Schneider. 1995. Rapid degradation of AU-rich element (ARE) mRNAs is activated by ribosome transit and blocked by secondary structure at any position 5′ to the ARE. Mol. Cell. Biol. 15:6331-6340.
13. Decker, C. J., and R. Parker. 1995. Diversity of cytoplasmic functions for the 3′ region of eukaryotic transcripts. Curr. Opin. Cell Biol. 7:386-392.
14. DeMaria, C. T., and G. Brewer. 1996. AUF1 binding affinity to A+U-rich elements correlates with rapid mRNA degradation. J. Biol. Chem. 271: 12179-12184.
15. DeMaria. C. T., Y. Sun, L. Long, B. J. Wagner, and G. Brewer. 1997. Structural determinants in AUF1 required for high affinity binding to A+U-rich elements. J. Biol. Chem. 272:27635-27643.
16. Dempsey, L. A., M. Li, A. DePace, P. Bray-Ward, and N. Maizels. 1998. The human HNRPD locus maps to 4q21 and encodes a highly conserved protein. Genomics 49:378-384.
17. Ehrenman, K., L. Long, B. J. Wagner, and G. Brewer. 1994. Characterization of cDNAs encoding the murine A+U-rich RNA-binding protein AUF1. Gene 149:315-319.
18. Geraghty, D. E., B. H. Koller, and H. T. Orr. 1987. A human major histocompatibility complex class I gene that encodes a protein with a shortened cytoplasmic segment. Proc. Natl. Acad. Sci. USA 84:9145-9149.
19. He, F., and A. Jacobson. 1995. Identification of a novel component of the nonsense-mediated mRNA decay pathway by use of an interacting protein screen. Genes Dev. 9:437-454.
20. Hesketh, J. E., and L F. Pryme. 1991. Interaction between mRNA, ribosomes and the cytoskeleton. Biochem. J. 277:1-10.
21. Hillier, L., N. Clark, T. Dubuque, K. Elliston, M. Hawkins, M. Holman, M. Hultman, T. Kucaba, M. Le, G. Lennon, M. Marra, J. Parsons, L. Rifkin, T. Rohlfing, F. Tan, E. Trevaskis, R. Waterston, A. Williamson, P. Wohldmann, and R. Wilson. 1995. GenBank accession no. H49797.
22. Howe, J. G., and J. W. B. Hershey. 1984. Translational initiation factor and ribosome association with the cytoskeletal framework fraction from HeLa cells. Cell 37:85-93.
23. Knezevic, V., M. Ranson, and S. Mackem. 1995. The organizer-associated chick homeobox gene, Gnot1, is expressed before gastrulation and regulated synergistically by activin and retinoic acid. Dev. Biol. 171:458-470.
24. Lafon, I., F. Carballes, G. Brewer, M. Poiret, and D. Morello. 1998. Developmental expression of AUF1 and HuR, two c-myc mRNA binding proteins. Oncogene 16:3413-3421.
25. Marra, M., L. Hillier, M. Allen, M. Bowles, N. Dietrich, T. Dubuque, S. Geisel, T. Kucaba, M. Lacy, M. Le, J. Martin, M. Morris, K. Schellenberg, M. Steptoe, F. Tan, K. Underwood, B. Moore, B. Theising, T. Wylie, G. Lennon, B. Soares, R. Wilson, and R. Waterston. 1996. GenBank accession no. AA250225.
26. Marra, M., L. Hillier, M. Allen, M. Bowles, N. Dietrich, T. Dubuque, S. Geisel, T. Kucaba, M. Lacy, M. Le, J. Martin, M. Morris, K. Schellenberg, M. Steptoe, F. Tan, K. Underwood, B. Moore, B. Theising, T. Wylie, G. Lennon, B. Soares, R. Wilson, and R. Waterston. 1996. GenBank accession no. AA645815.
27. Nagy, E., and L. E. Maquat. 1998. A rule for termination-codon position within intron-containing genes: when nonsense affects RNA abundance. Trends Biochem. Sci. 23:198-199.
28. Nielsen, F. C., S. Gammeltoft, and J. Christiansen. 1990. Translational discrimination of mRNAs coding for insulin-like growth factor II. J. Biol. Chem. 265:13431-13434.
29. Ouelette, A. J., M. B. Silverberg, and R. A. Malt. 1981. Association of poly(adenylate)-deficient messenger ribonucleic acid with membranes in mouse kidney. Biochemistry 20:3561-3567.
30. Peltz, S. W., A. H. Brown, and A. Jacobson. 1993. mRNA destabilization triggered by premature translational termination depends on at least three cis-acting sequence elements and one trans-acting factor. Genes Dev. 7:1737-1754.
31. Pende, A., K. D. Tremmel, C. T. DeMaria, B. C. Blaxall, W. A. Minobe, J. A. Sherman, J. D. Bisognano, M. R. Bristow, G. Brewer, and J. D. Port. 1996. Regulation of the mRNA-binding protein AUF1 by activation of the β-adrenergic receptor signal transduction pathway. J. Biol. Chem. 271:8493-8501.
32. Piechaczyk, M., J. Yang, J. Blanchard, P. Jeanteur, and K. B. Marcu. 1985. Posttranscriptional mechanisms are responsible for accumulation of truncated c-myc RNAs in murine plasma cell tumors. Cell 42:589-597.
33. Ranson, M., C. Tickle, K. A. Mahon, and S. Mackem. 1995. Gnot1, a member of a new homeobox gene subfamily, is expressed in a dynamic, region-specific domain along the proximodistal axis of the developing limb. Mech. Dev. 51:17-30.
34. Raymond, V., J. A. Atwater, and I. M. Verma. 1989. Removal of an mRNA destabilizing element correlates with increased oncogenicity of proto-oncogene c-fos. Oncogene Res. 4:861-865.
35. Ross, H., N. Sato, Y. Ueyama, and H. Koeffler. 1991. Cytokine messenger RNA stability is enhanced in tumor cells. Blood 77:1787-1795.
36. Ross, J. 1995. mRNA stability in mammalian cells. Microbiol. Rev. 59:423-450.
37. Ruiz-Echevarria, M. J., C. I. González, and S. W. Peltz. 1998. Identifying the right stop: determining how the surveillance complex recognizes and degrades an aberrant mRNA. EMBO J. 17:575-589.
38. Sachs, A. B. 1993. Messenger RNA degradation in eukaryotes. Cell 74:413-421.
39. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
40. Savant-Bhonsale, S., and D. W. Cleveland. 1992. Evidence for instability of mRNAs containing AUUUA motifs mediated through translation-depen-dent assembly of a >20S degradation complex. Genes Dev. 6:1927-1939.
41. Shukla, H., A. Swaroop, R. Srivastava, and S. M. Weissman. 1990. The mRNA of a human class I gene HLA G/HLA 6.0 exhibits a restricted pattern of expression. Nucleic Acids Res. 18:2189.
42. Sirenko, O. I., A. K. Lofquist, C. T. DeMaria, J. S. Morris, G. Brewer, and J. S. Haskill. 1997. Adhesion-dependent regulation of an A+U-rich element-binding activity associated with AUF1. Mol. Cell. Biol. 17:3898-3906.
43. Thermann, R., G. Neu-Yilik, A. Deters, U. Frede, K. Wehr, C. Hagemeier, M. W. Hentze, and A E. Kulozik. 1998. Binary specification of nonsense codons by splicing and cytoplasmic translation. EMBO J. 17:3484-3494.
44. Wagner, B. J., C. T. DeMaria, Y. Sun, G. M. Wilson, and G. Brewer. 1998. Structure and genomic organization of the human AUF1 gene: alternative pre-RNA splicing generates four protein isoforms. Genomics 48:195-202.
45. Wagner, B. J., L. Long, P. N. Rao, M. J. Pettenati, and G. Brewer. 1996. Localization and physical mapping of genes encoding the A+U-rich element RNA-binding protein AUF1 to human chromosomes 4 and X. Genomics 34:219-222.
46. Wilson, G. M., and G. Brewer. Unpublished observations.
47. Wilson, G. M., and G. Brewer. 1999. The search for trans-acting factors controlling messenger RNA decay. Prog. Nucleic Acid Res. Mol. Biol. 62: 257-291.
48. Wilson, G. M., E. A. Roberts, and R. G. Deeley. 1997. Modulation of LDL receptor mRNA stability by phorbol esters in human liver cell culture models. J. Lipid Res. 38:437-446.
49. Zhang, J., X. Sun, Y. Qian, J. P. LaDuca, and L. E. Maquat. 1998. At least one intron is required for the nonsense-mediated decay of triosephosphate isomerase mRNA: a possible link between nuclear splicing and cytoplasmic translation. Mol. Cell. Biol. 18:5272-5283.
50. Zhang, J., X. Sun, Y. Qian, and L. E. Maquat. 1998. Intron function in the nonsense-mediated decay of β-globin mRNA: indications that pre-mRNA splicing in the nucleus can influence mRNA translation in the cytoplasm. RNA 4:801-815.
51. Zhang, W., B. J. Wagner, K. Ehrenman, A. W. Schaefer, C. T. DeMaria, D. Crater, K. DeHaven, L. Long, and G. Brewer. 1993. Purification, characterization, and cDNA cloning of an AU-rich element RNA-binding protein, AUF1. Mol. Cell. Biol. 13:7652-7665.