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Volumn 284, Issue 5 47-5, 2003, Pages

Potential mechanisms and consequences of cardiac triacylglycerol accumulation in insulin-resistant rats

Author keywords

Acetyl CoA carboxylase; AMP activated protein kinase; Glycerol 3 phosphate acyltransferase; Glycolysis

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; ADENYLATE KINASE; FATTY ACID; FATTY ACID BINDING PROTEIN; GLUCOSE; GLYCEROL 3 PHOSPHATE ACYLTRANSFERASE; INSULIN; MALONYL COENZYME A; TRIACYLGLYCEROL;

EID: 0037403420     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.00360.2002     Document Type: Article
Times cited : (97)

References (43)
  • 1
    • 0036319122 scopus 로고    scopus 로고
    • MEDICA 16 inhibits hepatic acetyl-CoA carboxylase and reduces plasma triacylglycerol levels in insulin-resistant JCR:LA-cp rats
    • Atkinson LL, Kelly SE, Russell JC, Bar-Tana J, and Lopaschuk GD. MEDICA 16 inhibits hepatic acetyl-CoA carboxylase and reduces plasma triacylglycerol levels in insulin-resistant JCR:LA-cp rats. Diabetes 51: 1548-1555, 2002.
    • (2002) Diabetes , vol.51 , pp. 1548-1555
    • Atkinson, L.L.1    Kelly, S.E.2    Russell, J.C.3    Bar-Tana, J.4    Lopaschuk, G.D.5
  • 2
    • 0027486343 scopus 로고
    • Malonyl-CoA metabolism in cardiac myocytes and its relevance to the control of fatty acid oxidation
    • Awan MM and Saggerson DE. Malonyl-CoA metabolism in cardiac myocytes and its relevance to the control of fatty acid oxidation. Biochem J 295: 61-65, 1993.
    • (1993) Biochem J , vol.295 , pp. 61-65
    • Awan, M.M.1    Saggerson, D.E.2
  • 3
    • 0035929337 scopus 로고    scopus 로고
    • Insulin antagonizes AMPactivated protein kinase activation by ischemia or anoxia in rat hearts, without affecting total adenine nucleotides
    • Beauloye C, Marsin AS, Bertrand L, Krause U, Hardie DG, Vanoverschelde JL, and Hue L. Insulin antagonizes AMPactivated protein kinase activation by ischemia or anoxia in rat hearts, without affecting total adenine nucleotides. FEBS Lett 505: 348-352, 2001.
    • (2001) FEBS Lett , vol.505 , pp. 348-352
    • Beauloye, C.1    Marsin, A.S.2    Bertrand, L.3    Krause, U.4    Hardie, D.G.5    Vanoverschelde, J.L.6    Hue, L.7
  • 4
    • 0033662461 scopus 로고    scopus 로고
    • Altered metabolism causes cardiac dysfunction in perfused hearts from diabetic (db/db) mice
    • Belke DD, Larsen TS, Gibbs EM, and Severson DL. Altered metabolism causes cardiac dysfunction in perfused hearts from diabetic (db/db) mice. Am J Physiol Endocrinol Metab 279: E1104-E1113, 2000.
    • (2000) Am J Physiol Endocrinol Metab , vol.279
    • Belke, D.D.1    Larsen, T.S.2    Gibbs, E.M.3    Severson, D.L.4
  • 5
    • 0030991677 scopus 로고    scopus 로고
    • Uptake of long chain free fatty acids is selectively up-regulated in adipocytes of Zucker rats with genetic obesity and non-insulin-dependent diabetes mellitus
    • Berk PD, Zhou SL, Kiang CL, Stump D, Bradbury M, and Isola LM. Uptake of long chain free fatty acids is selectively up-regulated in adipocytes of Zucker rats with genetic obesity and non-insulin-dependent diabetes mellitus. J Biol Chem 272: 8830-8835, 1997.
    • (1997) J Biol Chem , vol.272 , pp. 8830-8835
    • Berk, P.D.1    Zhou, S.L.2    Kiang, C.L.3    Stump, D.4    Bradbury, M.5    Isola, L.M.6
  • 7
    • 0024551414 scopus 로고
    • Prophylaxis of early ventricular fibrillation by inhibition of acylcarnitine accumulation
    • Corr PB, Creer MH, Yamada KA, Saffitz JE, and Sobel BE. Prophylaxis of early ventricular fibrillation by inhibition of acylcarnitine accumulation. J Clin Invest 83: 927-936, 1989.
    • (1989) J Clin Invest , vol.83 , pp. 927-936
    • Corr, P.B.1    Creer, M.H.2    Yamada, K.A.3    Saffitz, J.E.4    Sobel, B.E.5
  • 8
    • 0025191281 scopus 로고
    • Effect of age on serum lipids and lipoproteins of male and female JCR:LA-corpulent rats
    • Dolphin PJ, Amy RM, and Russell JC. Effect of age on serum lipids and lipoproteins of male and female JCR:LA-corpulent rats. Biochim Biophys Acta 1042: 99-106, 1990.
    • (1990) Biochim Biophys Acta , vol.1042 , pp. 99-106
    • Dolphin, P.J.1    Amy, R.M.2    Russell, J.C.3
  • 9
    • 0030869792 scopus 로고    scopus 로고
    • Insulin inhibition of 5′ adenosine monophosphate-activated protein kinase in the heart results in activation of acetyl coenzyme A carboxylase and inhibition of fatty acid oxidation
    • Gamble J and Lopaschuk GD. Insulin inhibition of 5′ adenosine monophosphate-activated protein kinase in the heart results in activation of acetyl coenzyme A carboxylase and inhibition of fatty acid oxidation. Metabolism 46: 1270-1274, 1997.
    • (1997) Metabolism , vol.46 , pp. 1270-1274
    • Gamble, J.1    Lopaschuk, G.D.2
  • 10
    • 0033860359 scopus 로고    scopus 로고
    • Insulin resistance and cardiovascular disease
    • Ginsberg HN. Insulin resistance and cardiovascular disease. J Clin Invest 106: 453-458, 2000.
    • (2000) J Clin Invest , vol.106 , pp. 453-458
    • Ginsberg, H.N.1
  • 11
    • 0031007065 scopus 로고    scopus 로고
    • The AMP-activated protein kinase: Fuel gauge of the manimalian cell?
    • Hardie DG and Carling D. The AMP-activated protein kinase: fuel gauge of the manimalian cell? Eur JBiochem 246: 259-273, 1997.
    • (1997) Eur JBiochem , vol.246 , pp. 259-273
    • Hardie, D.G.1    Carling, D.2
  • 12
    • 0036316341 scopus 로고    scopus 로고
    • Increased efficiency of fatty acid uptake contributes to lipid accumulation in skeletal muscle of high fat-fed insulin-resistant rats
    • Hegarty BD, Cooney GJ, Kraegen EW, and Furler SM. Increased efficiency of fatty acid uptake contributes to lipid accumulation in skeletal muscle of high fat-fed insulin-resistant rats. Diabetes 51: 1477-1484, 2002.
    • (2002) Diabetes , vol.51 , pp. 1477-1484
    • Hegarty, B.D.1    Cooney, G.J.2    Kraegen, E.W.3    Furler, S.M.4
  • 13
    • 0021961854 scopus 로고
    • Separation and measurement of short-chain coenzyme-A compounds in rat liver by reversed-phase high-performance liquid chromatography
    • King MT and Reiss PD. Separation and measurement of short-chain coenzyme-A compounds in rat liver by reversed-phase high-performance liquid chromatography. Anal Biochem 146: 173-179, 1985.
    • (1985) Anal Biochem , vol.146 , pp. 173-179
    • King, M.T.1    Reiss, P.D.2
  • 14
    • 0029093341 scopus 로고
    • High rates of fatty acid oxidation during reperfusion of ischemic hearts are associated with a decrease in malonyl-CoA levels due to an increase in 5′AMP-activated protein kinase inhibition of acetyl-CoA carboxylase
    • Kudo N, Barr AJ, Barr RL, Desai S, and Lopaschuk GD. High rates of fatty acid oxidation during reperfusion of ischemic hearts are associated with a decrease in malonyl-CoA levels due to an increase in 5′AMP-activated protein kinase inhibition of acetyl-CoA carboxylase. J Biol Chem 270: 17513-17520, 1995.
    • (1995) J Biol Chem , vol.270 , pp. 17513-17520
    • Kudo, N.1    Barr, A.J.2    Barr, R.L.3    Desai, S.4    Lopaschuk, G.D.5
  • 15
    • 0030015194 scopus 로고    scopus 로고
    • Characterization of 5′AMP-activated protein kinase activity in the heart and its role in inhibiting acetyl-CoA carboxylase during reperfusion following ischemia
    • Kudo N, Gillespie JG, Kung L, Witters LA, Schulz R, Clanachan AS, and Lopaschuk GD. Characterization of 5′AMP-activated protein kinase activity in the heart and its role in inhibiting acetyl-CoA carboxylase during reperfusion following ischemia. Biochim Biophys Acta 1301: 67-75, 1996.
    • (1996) Biochim Biophys Acta , vol.1301 , pp. 67-75
    • Kudo, N.1    Gillespie, J.G.2    Kung, L.3    Witters, L.A.4    Schulz, R.5    Clanachan, A.S.6    Lopaschuk, G.D.7
  • 16
    • 0036217052 scopus 로고    scopus 로고
    • Disordered fat storage and mobilization in the pathogenesis of insulin resistance and type 2 diabetes
    • Lewis GF, Carpentier A, Khosrow A, and Giacca A. Disordered fat storage and mobilization in the pathogenesis of insulin resistance and type 2 diabetes. Endocr Rev 23: 201-229, 2002.
    • (2002) Endocr Rev , vol.23 , pp. 201-229
    • Lewis, G.F.1    Carpentier, A.2    Khosrow, A.3    Giacca, A.4
  • 17
    • 0030858058 scopus 로고    scopus 로고
    • Measurements of fatty acid and carbohydrate metabolism in the isolated working rat heart
    • Lopaschuk GD and Barr RL. Measurements of fatty acid and carbohydrate metabolism in the isolated working rat heart. Mol Cell Biochem 172: 137-147, 1997.
    • (1997) Mol Cell Biochem , vol.172 , pp. 137-147
    • Lopaschuk, G.D.1    Barr, R.L.2
  • 18
    • 0026076713 scopus 로고
    • Myocardial function and energy substrate metabolism in the insulin-resistant JCR:LA corpulent rat
    • Lopaschuk GD and Russell JC. Myocardial function and energy substrate metabolism in the insulin-resistant JCR:LA corpulent rat. J Appl Physiol 71: 1302-1308, 1991.
    • (1991) J Appl Physiol , vol.71 , pp. 1302-1308
    • Lopaschuk, G.D.1    Russell, J.C.2
  • 21
    • 0017738601 scopus 로고
    • A possible role for malonyl-CoA in the regulation of hepatic fatty acid oxidation and ketogenesis
    • McGarry JD, Mannaerts GP, and Foster DW. A possible role for malonyl-CoA in the regulation of hepatic fatty acid oxidation and ketogenesis. J Clin Invest 60: 265-270, 1977.
    • (1977) J Clin Invest , vol.60 , pp. 265-270
    • McGarry, J.D.1    Mannaerts, G.P.2    Foster, D.W.3
  • 23
    • 0033559856 scopus 로고    scopus 로고
    • AMP-activated kinase reciprocally regulates triacylglycerol synthesis and fatty acid oxidation in liver and muscle: Evidence that sn-glycerol-3-phosphate acyltransferase is a novel target
    • Muoio DM, Seefeld K, Witters LA, and Coleman RA. AMP-activated kinase reciprocally regulates triacylglycerol synthesis and fatty acid oxidation in liver and muscle: evidence that sn-glycerol-3-phosphate acyltransferase is a novel target. Biochem J 338: 783-791, 1999.
    • (1999) Biochem J , vol.338 , pp. 783-791
    • Muoio, D.M.1    Seefeld, K.2    Witters, L.A.3    Coleman, R.A.4
  • 24
    • 1842389677 scopus 로고
    • Relationship between carbohydrate and lipid metabolism and the energy balance of the heart muscle
    • Neely JR and Morgan HE. Relationship between carbohydrate and lipid metabolism and the energy balance of the heart muscle. Ann Rev Physiol 36: 415-439, 1974.
    • (1974) Ann Rev Physiol , vol.36 , pp. 415-439
    • Neely, J.R.1    Morgan, H.E.2
  • 27
    • 0027512732 scopus 로고
    • Role of insulin resistance in human disease (syndrome X): An expanded definition
    • Reaven GM. Role of insulin resistance in human disease (syndrome X): an expanded definition. Annu Rev Med 44: 121-131, 1993.
    • (1993) Annu Rev Med , vol.44 , pp. 121-131
    • Reaven, G.M.1
  • 29
    • 0029016886 scopus 로고
    • Inhibition of atherosclerosis and myocardial lesions in the JCR:LA-cp rat by beta,beta′-tetramethylhexadecanedioic acid (MEDICA 16)
    • Russell JC, Amy RM, Graham SE, Dolphin PJ, Wood GO, and Bar-Tana J. Inhibition of atherosclerosis and myocardial lesions in the JCR:LA-cp rat by beta,beta′-tetramethylhexadecanedioic acid (MEDICA 16). Artierioscler Thromb Vasc Biol 15: 918-923, 1995.
    • (1995) Artierioscler Thromb Vasc Biol , vol.15 , pp. 918-923
    • Russell, J.C.1    Amy, R.M.2    Graham, S.E.3    Dolphin, P.J.4    Wood, G.O.5    Bar-Tana, J.6
  • 30
    • 0030960457 scopus 로고    scopus 로고
    • Cardioprotective and hypolipidemic effects of nisoldipine in the JCR: LA-cp rat
    • Russell JC, Dolphin PJ, Graham SE, and Amy RM. Cardioprotective and hypolipidemic effects of nisoldipine in the JCR: LA-cp rat. J Cardiovasc Pharmacol 29: 586-592, 1997.
    • (1997) J Cardiovasc Pharmacol , vol.29 , pp. 586-592
    • Russell, J.C.1    Dolphin, P.J.2    Graham, S.E.3    Amy, R.M.4
  • 31
    • 0025354137 scopus 로고
    • Prevention of myocardial lesions in JCR:LA-cp corpulent rats by nifedipine
    • Russell JC, Koeslag DG, Dolphin PJ, and Amy RM. Prevention of myocardial lesions in JCR:LA-cp corpulent rats by nifedipine. Arteriosclerosis 10: 658-664, 1990.
    • (1990) Arteriosclerosis , vol.10 , pp. 658-664
    • Russell, J.C.1    Koeslag, D.G.2    Dolphin, P.J.3    Amy, R.M.4
  • 33
    • 0027453493 scopus 로고
    • Acetyl-CoA carboxylase regulation of fatty acid oxidation in the heart
    • Saddik M, Gamble J, Witters LA, and Lopaschuk GD. Acetyl-CoA carboxylase regulation of fatty acid oxidation in the heart. J Biol Chem 268: 25836-25845, 1993.
    • (1993) J Biol Chem , vol.268 , pp. 25836-25845
    • Saddik, M.1    Gamble, J.2    Witters, L.A.3    Lopaschuk, G.D.4
  • 34
    • 0032213768 scopus 로고    scopus 로고
    • AMP-activated protein kinase is activated by low glucose in cell lines derived from pancreatic beta cells, and may regulate insulin release
    • Salt IP, Johnson G, Ashcroft SJ, and Hardie DG. AMP-activated protein kinase is activated by low glucose in cell lines derived from pancreatic beta cells, and may regulate insulin release. Biochem J 335: 533-539, 1998.
    • (1998) Biochem J , vol.335 , pp. 533-539
    • Salt, I.P.1    Johnson, G.2    Ashcroft, S.J.3    Hardie, D.G.4
  • 35
    • 0342506484 scopus 로고    scopus 로고
    • Regulation of energy substrate metabolism in the diabetic heart
    • Stanley WC, Lopaschuk GD, and McCormack JG. Regulation of energy substrate metabolism in the diabetic heart. Cardiovasc Res 34: 25-33, 1997.
    • (1997) Cardiovasc Res , vol.34 , pp. 25-33
    • Stanley, W.C.1    Lopaschuk, G.D.2    McCormack, J.G.3
  • 36
    • 0031576031 scopus 로고    scopus 로고
    • Glycerolipid metabolizing enzymes in rat ventricle and in cardiac myocytes
    • Swanton EMS and Saggerson ED. Glycerolipid metabolizing enzymes in rat ventricle and in cardiac myocytes. Biochim Biophys Acta 1346: 93-102, 1997.
    • (1997) Biochim Biophys Acta , vol.1346 , pp. 93-102
    • Swanton, E.M.S.1    Saggerson, E.D.2
  • 38
    • 0032792665 scopus 로고    scopus 로고
    • AMP-activated protein kinase, a metabolic master switch: Possible roles in type 2 diabetes
    • Winder WW and Hardie DG. AMP-activated protein kinase, a metabolic master switch: possible roles in type 2 diabetes. Am J Physiol Endocrinol Metab 277: E1-E10, 1999.
    • (1999) Am J Physiol Endocrinol Metab , vol.277
    • Winder, W.W.1    Hardie, D.G.2
  • 39
    • 0026782061 scopus 로고
    • Insulin activation of acetyl-CoA carboxylase accompanied by inhibition of the 5′-AMP-activated protein kinase
    • Witters LA and Kemp BE. Insulin activation of acetyl-CoA carboxylase accompanied by inhibition of the 5′-AMP-activated protein kinase. J Biol Chem 267: 2864-2867, 1992.
    • (1992) J Biol Chem , vol.267 , pp. 2864-2867
    • Witters, L.A.1    Kemp, B.E.2
  • 40
    • 0031046730 scopus 로고    scopus 로고
    • Phenotype of the obese Koletsky (f) rat due to Tyr763Stop mutation in the extracellular domain of the leptin receptor (Lepr)
    • Wu-Peng WS, Chua SC Jr, Okada N, Liu SM, Nicolson M, and Leibel RL. Phenotype of the obese Koletsky (f) rat due to Tyr763Stop mutation in the extracellular domain of the leptin receptor (Lepr). Diabetes 46: 513-518, 1997.
    • (1997) Diabetes , vol.46 , pp. 513-518
    • Wu-Peng, W.S.1    Chua S.C., Jr.2    Okada, N.3    Liu, S.M.4    Nicolson, M.5    Leibel, R.L.6
  • 43
    • 0027383771 scopus 로고
    • Diabetes and the heart: State of the art in the 1990s
    • Zoneraich S and Mollura JL. Diabetes and the heart: state of the art in the 1990s. Can J Cardiol 9: 293-299, 1993.
    • (1993) Can J Cardiol , vol.9 , pp. 293-299
    • Zoneraich, S.1    Mollura, J.L.2


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