Polymorphisms in the SLC2A2 (GLUT2) gene are associated with the conversion from impaired glucose tolerance to type 2 diabetes: The Finnish Diabetes Prevention Study

Diabetes

Volumn 54, Issue 7, 2005, Pages 2256-2260

  Laukkanen, Olli ^a   Lindström, Jaana ^b   Eriksson, Johan ^b   Valle, Timo T ^b   Hämäläinen, Helena ^c   Ilanne Parikka, Pirjo ^d   Keinänen Kiukaanniemi, Sirkka ^e,f   Tuomilehto, Jaakko ^b,g   Uusitupa, Matti ^a   Laakso, Markku ^a  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^c SOCIAL INSURANCE INSTITUTION   (Finland)

^d TAMPERE UNIVERSITY HOSPITAL   (Finland)

^e UNIVERSITY OF OULU   (Finland)

^f OULU DEACONESS INSTITUTE   (Finland)

^g UNIVERSITY OF HELSINKI   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE TRANSPORTER 2;

ADULT; ALLELISM; ARTICLE; CONTROLLED STUDY; DISEASE ACTIVITY; DISEASE COURSE; FINLAND; GCK GENE; GENE; GENETIC ASSOCIATION; GENETIC CODE; GENETIC EPIDEMIOLOGY; GENETIC POLYMORPHISM; GENETIC RISK; GENOTYPE; HETEROZYGOTE; HUMAN; IMPAIRED GLUCOSE TOLERANCE; INSULIN RELEASE; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; PROMOTER REGION; RISK ASSESSMENT; SINGLE NUCLEOTIDE POLYMORPHISM; SLC2A2 GENE; TCF1 GENE;

ANALYSIS OF VARIANCE; DIABETES MELLITUS, TYPE 2; DISEASE PROGRESSION; FINLAND; GENOTYPE; GLUCOSE INTOLERANCE; GLUCOSE TRANSPORTER TYPE 2; HUMANS; MONOSACCHARIDE TRANSPORT PROTEINS; MULTIVARIATE ANALYSIS; OBESITY; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS;

EID: 21344437030     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.54.7.2256     Document Type: Article

References (24)

1. Mueckler M: Facultative glucose transporters. Eur J Biochem 219:713-725, 1994
2. Barroso I, Luan J, Middelberg RP, Harding AH, Franks PW, Jakes RW, Clayton D, Schafer AJ, O'Rahilly S, Wareham NJ: Candidate gene association study in type 2 diabetes indicates a role for genes involved in beta-cell function as well as insulin action. PLoS Biol 1:41-55, 2003
3. Alcolado JC, Baroni MG, Li SR: Association between a restriction fragment length polymorphism at the liver/islet cell (GluT 2) glucose transporter and familial type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia 34:734-736, 1991
4. Matsutani A, Koranyi L, Cox N, Permutt MA: Polymorphisms of GLUT2 and GLUT4 genes: use in evaluation of genetic susceptibility to NIDDM in blacks. Diabetes 39:1534-1542, 1990
5. Patel P, Bell GI, Cook JT, Turner RC, Wainscoat JS: Multiple restriction fragment length polymorphisms at the GLUT2 locus: GLUT2 haplotypes for genetic analysis of type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia 34:817-821, 1991
6. Li SR, Alcolado JC, Stocks J, Baroni MG, Oelbaum RS, Galton DJ: Genetic polymorphisms at the human liver/islet glucose transporter (GLUT2) gene locus in Caucasian and West Indian subjects with type 2 (non-insulin-dependent) diabetes mellitus. Biochim Biophys Acta 1097:293-298, 1991
7. Baroni MG, Alcolado JC, Pozzilli P, Cavallo MG, Li SR, Galton DJ: Polymorphisms at the GLUT2 (beta-cell/liver) glucose transporter gene and non-insulin-dependent diabetes mellitus (NIDDM): analysis in affected pedigree members. Clin Genet 41:229-234, 1992
8. Tanizawa Y, Riggs AC, Chiu KC, Janssen RC, Bell DS, Go RP, Roseman JM, Acton RT, Permutt MA: Variability of the pancreatic islet beta cell/liver (GLUT 2) glucose transporter gene in NIDDM patients. Diabetologia 37:420-427, 1994
9. Shimada F, Makino H, Iwaoka H, Miyamoto S, Hashimoto N, Kanatsuka A, Bell GI, Yoshida S: Identification of two novel amino acid polymorphisms in beta-cell/liver (GLUT2) glucose transporter in Japanese subjects. Diabetologia 38:211-215, 1995
10. Matsubara A, Tanizawa Y, Matsutani A, Kaneko T, Kaku K: Sequence variations of the pancreatic islet/liver glucose transporter (GLUT2) gene in Japanese subjects with noninsulin dependent diabetes mellitus. J Clin Endocrinol Metab 80:3131-3135, 1995
11. Møller AM, Jensen NM, Pildal J, Drivsholm T, Borch-Johnsen K, Urhammer SA, Hansen T, Pedersen O: Studies of genetic variability of the glucose transporter 2 promoter in patients with type 2 diabetes mellitus. J Clin Endocrinol Metab 86:2181-2186, 2001
12. Matschinsky F, Liang Y, Kesavan P, Wang L, Froguel P, Velho G, Cohen D, Permutt MA, Tanizawa Y, Jetton TL, et al: Glucokinase as pancreatic beta cell glucose sensor and diabetes gene (Review). J Clin Invest 92:2092-2098, 1993
13. Stone LM, Kahn SE, Fujimoto WY, Deeb SS, Porte D Jr: A variation at position-30 of the β-cell glucokinase gene promoter is associated with reduced β-cell function in middle-aged Japanese-American men. Diabetes 45:422-428, 1996
14. Yamada K, Yuan X, Ishiyama S, Ichikawa F, Koyama KI, Koyanagi A, Koyama W, Nonaka K: Clinical characteristics of Japanese men with glucokinase gene β-cell promoter variant. Diabetes Care 20:1159-1161, 1997
15. März W, Nauck M, Hoffmann MM, Nagel D, Boehm BO, Koenig W, Rothenbacher D, Winkelmann BR: G(-30)A polymorphism in the pancreatic promoter of the glucokinase gene associated with angiographic coronary artery disease and type 2 diabetes mellitus. Circulation 109:2844-2849, 2004
16. Hegele RA, Zinman B, Hanley AJ, Harris SB, Barrett PH, Cao H: Genes, environment and Qji-Cree type 2 diabetes. Clin Biochem 36:163-170, 2003
17. Silander K, Mohlke KL, Scott LJ, Peck EC, Hollstein P, Skol AD, Jackson AU, Deloukas P, Hunt S, Stavrides G, Chines PS, Erdos MR, Narisu N, Conneely KN, Li C, Fingerlin TE, Dhanjal SK, Valle TT, Bergman RN, Tuomilehto J, Watanabe RM, Boehnke M, Collins FS: Genetic variation near the hepatocyte nuclear factor-4 alpha gene predicts susceptibility to type 2 diabetes. Diabetes 53:1141-1149, 2004
18. Love-Gregory LD, Wasson J, Ma J, Jin CH, Glaser B, Suarez BK, Permutt MA: A common polymorphism in the upstream promoter region of the hepatocyte nuclear factor-4 α gene on chromosome 20q is associated with type 2 diabetes and appears to contribute to the evidence for linkage in an Ashkenazi Jewish population. Diabetes 53:1134-1140, 2004
19. Weedon MN, Owen KR, Shields B, Hitman G, Walker M, McCarthy MI, Love-Gregory LD, Permutt MA, Hattersley AT, Frayling TM: Common variants of the hepatocyte nuclear factor-4α P2 promoter are associated with type 2 diabetes in the U.K. population. Diabetes 53:3002-3006, 2004
20. Vilsbøll T, Holst JJ: Incretins, insulin secretion and type 2 diabetes mellitus. Diabetologia 47:357-366, 2004
21. Tuomilehto J, Lindström J, Eriksson JG, Valle TT, Hämäläinen H, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Laakso M, Louheranta A, Rastas M, Salminen V, Uusitupa M: Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med 344:1343-1350, 2001
22. World Health Organization: Diabetes Mellitus: Report of a WHO Study Group. Geneva, World Health Org., 1985 (Tech. Rep. Ser. no. 727)
23. Laukkanen O, Pihlajamäki J, Lindström J, Eriksson J, Valle TT, Hämäläinen H, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Tuomilehto J, Uusitupa M, Laakso M: Polymorphisms of the SUR2 (ABCC8) and Kir6.2 (KCNJ11) genes predict the conversion from impaired glucose tolerance to type 2 diabetes: The Finnish Diabetes Prevention Study. J Clin Endocrinol Metab 89:6286-6290, 2004
24. Uusitupa M, Lindi V, Louheranta A, Salopuro T, Lindstrom J, Tuomilehto J for the Finnish Diabetes Prevention Study Group: Long-term improvement in insulin sensitivity by changing lifestyles of people with impaired glucose tolerance: 4-year results from the Finnish Diabetes Prevention Study. Diabetes 52:2532-2538, 2003