Lamotrigine has an anxiolytic-like profile in the rat conditioned emotional response test of anxiety: A potential role for sodium channels?

Psychopharmacology

Volumn 180, Issue 1, 2005, Pages 159-168

  Mirza, N R ^a,b   Bright, J L ^a   Stanhope, K J ^a   Wyatt, A ^a   Harrington, N R ^a  

^a Vernalis PLC   (United Kingdom)

^b NEUROSEARCH A S   (Denmark)

Author keywords

Anxiety; Carbamazepine; Chlordiazepoxide; Conditioned fear; Diazepam; Lamotrigine; Na+ channels; Rat; Riluzole; Veratrine

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR STIMULATING AGENT; ANTICONVULSIVE AGENT; BAYK 8644; BENZODIAZEPINE DERIVATIVE; BENZODIAZEPINE RECEPTOR STIMULATING AGENT; CALCIUM CHANNEL BLOCKING AGENT; CARBAMAZEPINE; CEVADINE; CHLORDIAZEPOXIDE; DIAZEPAM; DIZOCILPINE; LAMOTRIGINE; MEMANTINE; METERGOLINE; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; NIFEDIPINE; PAROXETINE; PROPOFOL; RILUZOLE; SEROTONIN 1 ANTAGONIST; SEROTONIN 1A ANTAGONIST; SEROTONIN 2 ANTAGONIST; SEROTONIN UPTAKE INHIBITOR; SODIUM CHANNEL; UNCLASSIFIED DRUG; VALPROIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANXIETY; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; EMOTION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; TRANQUILIZING ACTIVITY;

ANIMALS; ANTI-ANXIETY AGENTS; ANTICONVULSANTS; ANXIETY; CALCIUM CHANNEL AGONISTS; CALCIUM CHANNEL BLOCKERS; CONDITIONING, CLASSICAL; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; EMOTIONS; MALE; RATS; RECEPTORS, GABA-A; RECEPTORS, N-METHYL-D-ASPARTATE; SEROTONIN UPTAKE INHIBITORS; SODIUM CHANNEL BLOCKERS; SYNAPTIC TRANSMISSION; TRIAZINES;

EID: 21244501728     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00213-005-2146-1     Document Type: Article

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