The isoforms of phospholipase C-γ are differentially used by distinct human NK activating receptors

Journal of Immunology

Volumn 175, Issue 1, 2005, Pages 213-218

  Upshaw, Jadee L ^a   Schoon, Renee A ^a   Dick, Christopher J ^a   Billadeau, Daniel D ^b   Leibson, Paul J ^a  

^a MAYO GRADUATE SCHOOL   (United States)

^b Mayo Clinic   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL SURFACE RECEPTOR; MEMBRANE PROTEIN; NATURAL KILLER CELL RECEPTOR NKG2D; PHOSPHOLIPASE C GAMMA; PROTEIN DAP10; PROTEIN KINASE C; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIGEN RECOGNITION; ARTICLE; CELL ACTIVATION; CELL FUNCTION; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; CYTOTOXICITY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNORECEPTOR TYROSINE BASED ACTIVATION MOTIF; NATURAL KILLER CELL; NONHUMAN; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN MOTIF;

EID: 21244488551     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.175.1.213     Document Type: Article

References (19)

1. Vivier, E., J. A. Nunes, and F. Vely. 2004. Natural killer cell signaling pathways. Science 306: 1517-1519.
2. Bauer, S., V. Groh, J. Wu, A. Steinle, J. H. Phillips, L. L. Lanier, and T. Spies. 1999. Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA. Science 285: 727-729.
3. Wu, J., Y, Song, A. B. Bakker, S. Bauer, T. Spies, L. L. Lanier, and J. H. Phillips. 1999. An activating immunoreceptor complex formed by NKG2D and DAP10. Science 285: 730-732.
4. Wilde, J. I., and S. P. Watson. 2001. Regulation of phospholipase Cγ isoforms in haematopoietic cells: why one, not the other? Cell. Signal. 13: 691-701.
5. Wang, D., J. Feng, R. Wen, J. C. Marine, M. Y. Sangster, E, Parganas, A. Hoffmeyer, C. W. Jackson, J. L. Cleveland, P. J. Murray, and J. N. Ihle. 2000. Phospholipase Cγ2 is essential in the functions of B cell and several Fc receptors. Immunity 13: 25-35.
6. Hashimoto, A., K. Takeda, M. Inaba, M. Sekimata, T. Kaisho, S. Ikehara, Y. Homma, S. Akira, and T. Kurosaki. 2000. Cutting edge: essential role of phospholipase C-γ2 in B cell development and function. J. Immunol. 165: 1738-1742.
7. Ting, A. T., L. M. Karnitz, R. A. Schoon, R. T. Abraham, and P. J. Leibson. 1992. Fcγ receptor activation induces the tyrosine phosphorylation of both phospholipase C (PLC)-γ1 and PLC-γ2 in natural killer cells. J. Exp. Med. 176: 1751-1755.
8. Windebank, K. P., R. T. Abraham, G. Powis, R. A. Olsen, T. J. Barna, and P. J. Leibson. 1988. Signal transduction during human natural killer cell activation: inositol phosphate generation and regulation by cyclic AMP. J. Immunol. 141: 3951-3957.
9. Billadeau, D. D., J. L. Upshaw, R. A. Schoon, C. J. Dick, and P. J. Leibson. 2003. NKG2D-DAP10 triggers human NK cell-mediated killing via a Syk-independent regulatory pathway. Nat. Immunol. 4: 557-564.
10. Billadeau, D. D., K. M. Brumbaugh, C. J. Dick, R. A. Schoon, X. R. Bustelo, and P. J. Leibson. 1998. The Vav-Rac1 pathway in cytotoxic lymphocytes regulates the generation of cell-mediated killing. J. Exp. Med. 188: 549-559.
11. Billadeau, D. D., S. M. Mackie, R. A. Schoon, and P. J. Leibson. 2000. Specific subdomains of Vav differentially affect T cell and NK cell activation. J. Immunol. 164: 3971-3981.
12. Irvin, B. J., B. L. Williams, A. E. Nilson, H. O. Maynor, and R. T. Abraham. 2000. Pleiotropic contributions of phospholipase C-γ1 (PLC-γ1) to T-cell antigen receptor-mediated signaling: reconstitution studies of a PLC-γ1-deficient Jurkat T-cell line. Mol. Cell. Biol. 20: 9149-9161.
13. Jamieson, A. M., A. Diefenbach, C. W. McMahon, N. Xiong, J. R. Carlyle, and D. H. Raulet. 2002. The role of the NKG2D immunoreceptor in immune cell activation and natural killing. Immunity 17: 19-29.
14. Meresse, B., Z. Chen, C. Ciszewski, M. Tretiakova, G. Bhagat, T. N. Krausz, D. H. Raulet, L. L. Lanier, V. Groh, T. Spies, et al. 2004. Coordinated induction by IL15 of a TCR-independent NKG2D signaling pathway converts CTL into lymphokine-activated killer cells in celiac disease. Immunity 21: 357-366.
15. Colucci, F., E. Schweighoffer, E. Tomasello, M. Turner, J. R. Ortaldo, E. Vivier, V. L. Tybulewicz, and J. P. Di Santo. 2002. Natural cytotoxicity uncoupled from the Syk and ZAP-70 intracellular kinases. Nat. Immunol. 3: 288-294.
16. Zompi, S., J. A. Hamerman, K. Ogasawara, E. Schweighoffer, V. L. Tybulewicz, J. P. Di Santo, L. L. Lanier, and F. Colucci. 2003. NKG2D triggers cytotoxicity in mouse NK cells lacking DAP12 or Syk family kinases. Nat. Immunol. 4: 565-572.
17. Colucci, F., E. Rosmaraki, S. Bregenholt, S. I. Samson, V. Di Bartolo, M. Turner, L. Vanes, V. Tybulewicz, and J. P. Di Santo. 2001. Functional dichotomy in natural killer cell signaling: Vav1-dependent and -independent mechanisms. J. Exp. Med. 193: 1413-1424.
18. Cella, M., K. Fujikawa, I. Tassi, S. Kim, K. Latinis, S. Nishi, W. Yokoyama, M. Colonna, and W. Swat. 2004. Differential requirements for Vav proteins in DAP10- and ITAM-mediated NK cell cytotoxicity. J. Exp. Med. 200: 817-823.
19. Roberts, A. I., L. Lee, E. Schwarz, V. Groh, T. Spies, E. C. Ebert, and B. Jabri. 2001. NKG2D receptors induced by IL-15 costimulate CD28-negative effector CTL in the tissue microenvironment. J. Immunol. 167: 5527-5530.