The evolutionary history of the CCR5-Δ32 HIV-resistance mutation

Microbes and Infection

Volumn 7, Issue 2, 2005, Pages 302-309

  Galvani, Alison P ^a   Novembre, John ^b  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

CCR5; Evolution; HIV; Population genetics

Indexed keywords

CHEMOKINE RECEPTOR CCR5;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ALLELE; DNA POLYMORPHISM; DRUG DESIGN; GENE FREQUENCY; GENE LOCUS; GENE MUTATION; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC RESISTANCE; GENETIC SELECTION; GENETIC VARIABILITY; GEOGRAPHIC DISTRIBUTION; HOST PATHOGEN INTERACTION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE RESPONSE; INFLAMMATION; MOLECULAR EVOLUTION; MOLECULAR MODEL; NONHUMAN; POPULATION GENETICS; PRIMATE; PRIORITY JOURNAL; REVIEW; SIMIAN IMMUNODEFICIENCY VIRUS; VIRUS RESISTANCE; GENE DELETION; GENETICS; MUTATION;

EVOLUTION, MOLECULAR; GENE DELETION; HIV INFECTIONS; HIV-1; HUMANS; MUTATION; RECEPTORS, CCR5;

EID: 21244484209     PISSN: 12864579     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.micinf.2004.12.006     Document Type: Short Survey

References (75)

1. + cells is mediated by the chemokine receptor CC-CkR5 Nature 381 1996 667 673
2. S.J. O'Brien, and J.P. Moore The effect of genetic variation in chemokines and their receptors on HIV transmission and progression to AIDS Immunol. Rev. 177 2000 99 111
3. T. Dragic A binding pocket for a small molecule inhibitor of HIV-1 entry within the transmembrane helices of CCR Proc. Natl. Acad. Sci. USA 97 2000 5639 5644
4. M. Dean Genetic restriction of HIV-1 infection and progression to AIDS by a deletion allele of the CCR5 structural gene Science 73 1996 856 1862
5. L.X. Liu, C.N. Serhan, and P.F. Weller Intravascular filarial parasites elaborates cyclooxygenase-derived eicosanoids J. Exp. Med. 172 1990 993 996
6. M. Samson Resistance to HIV-1 infection in Caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene Nature 382 1996 722 725
7. R. Liu Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection Cell 86 1996 367 377
8. N.L. Michael The role of viral phenotype and CCR-5 gene defects in HIV-1 transmission and disease progression Nat. Med. 3 1997 338 340
9. T. O'Brien HIV-1 infection in a man homozygous for CCR5-D32 Lancet 349 1997 1219
10. P.A. Zimmerman Inherited resistance to HIV-1 conferred by an inactivating mutation in CC chemokine receptor 5-studies in populations with contrasting clinical phenotypes, defined racial background, and qualified risk Mol. Med. 3 1997 23 26
11. P. Schliekelman, C. Garner, and M. Slatkin Natural selection and resistance to HIV Nature 411 2001 545 546
12. J.J. Martinson Global distributon of the CCR5 gene 32-bp deletion Nat. Genet. 16 1997 100 102
13. J.C. Stephens Dating the origin of the CCR5-D32 AIDS-resistance allele by the coalescence of haplotypes Am. J. Hum. Genet. 62 1998 1507 1515
14. S.J. O'Brien, and M. Dean In search of AIDS-resistance genes Sci. Am. 277 1997 44 51
15. M. Slatkin, and R.R. Hudson Pairwise comparisons of mitochondrial DNA sequences in stable and exponentionally growing populations Genetics 129 1991 555 562
16. F. Libert The deltaCCR5 mutation conferring protection against HIV-1 in Caucasian populations has a single and recent origin in Northeastern Europe Hum. Mol. Genet. 7 1998 399 406
17. J. Hastbacka Linkage disequilibrium mapping in isolated founder populations: disastrophic dysplasia in Finland Nat. Genet. 2 1992 204 211
18. G. Lucotte Distribution of the CCR5 gene 32-bp deletion in West Europe. A hypothesis about the possible dispersion of the mutation by the Vikings in historical times Hum. Immunol. 62 2001 933 936
19. J. Hatcher Plague, Population and the English Economy 1348-1530 1977 The MacMillan Press Ltd. London
20. C. McEvedy The bubonic plague Sci. Am. 258 1988 118 123
21. J.M.W. Bean Plague, population and economic decline in England The Later Middle Ages, second series 1963 E.H.R. xv
22. R.S. Gottfried The Black Death: Natural and Human Disaster in Medieval Europe 1983 The Free Press New York
23. J.C. Giblin When Plague Strikes: The Black Death, Smallpox 1995 AIDS Harper Trophy, New York
24. A.P. Galvani, and M.W. Slatkin Intense selection in an age-structured population Proc. R. Soc. Lond. B. Biol. Sci. 271 2004 171 176
25. A.P. Galvani, and M.W. Slatkin Evaluating plague and smallpox as historical selective pressures for the CCR5-delta32 HIV-resistance allele Proc. Natl. Acad. Sci. USA 100 2003 15276 15279
26. C. Galley The Demography of Early Modern Towns: York in the Sixteenth and Seventeenth Centuries 1998 Liverpool University Press Liverpool
27. D.R. Hopkins The Greatest Killer in History: Smallpox 2002 The University of Chicago Press Chicago and London
28. R.M. Anderson, and R.M. May Infectious Diseases of Humans: Dynamics and Control 1991 Oxford University Press Oxford
29. F. Fenner Smallpox and its Eradication 1988 World Health Organization Geneva
30. A.S. Lalani Use of Chemokine Receptors by Poxviruses Science 286 1999 1968 1971
31. A. Carfi Structure of a soluble secreted chemokine inhibitor vCCI (p35) from cowpox virus Proc. Natl. Acad. Sci. USA 96 1999 12379 12383
32. B.T. Seet Poxviruses and immune evasion Annu. Rev. Immunol. 21 2003 377 423
33. P.C. Reading, J.A. Symons, and G.L. Smith A soluble chemokine-binding protein from vaccinia virus reduces virus virulence and the inflammatory response to infection J. Immunol. 170 2003 1435 1442
34. J. Mecsas Ambiguous role of CCR5 in Y. pestis infection Nature 427 2004 606
35. S.J. Elvin Evolutionary genetics: ambiguous role of CCR5 in Y. pestis infection Nature 430 2004 418
36. L. Wu CCR5 levels and expression pattern correlate with infectability by macrophage-tropic HIV-1, in vitro J. Exp. Med. 185 1997 1681 1691
37. M. Benkirane Mechanism of transdominant inhibition of CCR5-mediated HIV-1 infection by CCR5-d32 J. Biol. Chem. 272 1997 30603 30606
38. M. Slatkin Simulating genealogies of selected alleles in a population of variable size Genet. Res. 78 2001 49 57
39. F. Vogel, and A.G. Motulsky Human Genetics: Problems and Approaches. Third Emerging Disease 1997 Springer Berlin
40. K. Kurashima Elevated chemokine levels in bronchoalveolar lavage fluid of tuberculosis patients Am. J. Respir. Crit. Care Med. 155 1997 1474 1477
41. D.N. Cook Requirement of MIP-1 alpha for an inflammatory response to viral infection Science 269 1995 1583 1585
42. G.B. Huffnagle Role of C-C chemokine receptor 5 in organ specific and innate immunity to Cryptococcus neoformans J. Immunol. 163 1999 4642 4646
43. N. Sato Defects in the generation of IFN are overcome to control infection with Leishmania donovani in C-C chemokine receptor (CCR) 5-, macrophage inflammatory protein-1 alpha-, or CCR2-deficient mice J. Immunol. 163 1999 5519 5525
44. J. Aliberti CCR5 provides a signal for microbial induced production of IL-12 by CD8a+ dendritic cells Nat. Immunol. 1 2000 83 87
45. Y.-W. Zhang, O.A. Ryder, and Y.-P. Zhang Intra- and interspecific variation of the CCR5 gene in higher primates Mol. Biol. Evol. 20 2003 1722 1729
46. M.B.A. Oldstone Viruses 1998 Plagues and History, Oxford University Press Oxford
47. D. Nolan Impact of host genetics on HIV disease progression and treatment: new conflicts on an ancient battleground AIDS 18 2004 1231 1240
48. M.J. Silverberg Fraction of cases of acquired immunodeficiency syndrome prevented by the interactions of identified restriction gene variants Am. J. Epidemiol. 159 2004 232 241
49. M. Carrington, and S.J. O'Brien The influence of HLA genotype on AIDS Am. Rev. Med. 54 2003 535 551
50. M.P. Martin Genetic acceleration of AIDS progression by a promoter variant of CCR5 Science 282 1998 1907 1911
51. P. An Influence of CCR5 promoter haplotypes on AIDS progression in African-Americans AIDS 14 2000 2117 2122
52. M.J. Bamshad A strong signature of balancing selection in the 5′ cis-regulatory region of CCR5 Proc. Natl. Acad. Sci. USA 99 2002 10539 10544
53. C. Winkler Genetic restriction of AIDS pathogenesis by an SDF-1 chemokine gene variant Science 279 1998 389 393
54. A.O. Anzala CCR2-641 allele and genotype association with delayed AIDS progression in African women Lancet 351 1998 1632 1633
55. R. Veazey Decreased CCR5 expression on CD4+ T cells of SIV-infected sooty mangabeys AIDS Res. Hum. Retroviruses 19 2003 227 233
56. L.A. Chakrabarti Normal T-cell turnover in sooty mangabeys harboring active simian immunodeficiency virus infection J. Virol. 74 2000 1209 1223
57. P. Fultz Isolation of a T-lymphotrophic retrovirus from naturally infected sooty mangabey monkeys (Cercocebus atys) Proc. Natl. Acad. Sci. USA 83 1986 5286 5290
58. Z. Chen Natural infection of a homozygous delta24 CCR5 red-capped mangabey with an R2b-tropic simian immunodeficiency virus J. Exp. Med. 188 1998 2057 2065
59. E. Palacios Parallel evolution of CCR5-null phenotypes in humans and in a natural host of simian immunodeficiency virus Curr. Biol 8 1998 943 946 and S1-S3
60. D. Finzi Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy Nat. Med. 5 1999 512 517
61. G.M. Lucas, R.E. Chaisson, and R.D. Moore Highly active antiretroviral therapy in a large urban clinic: risk factors for virologic failure and adverse drug reactions Ann. Intern. Med. 131 1999 81 87
62. S. Yerly Transmission of antiretroviral-drug-resistant HIV-1 variants Lancet 354 1999 729 733
63. Z. Chen Genetically divergent strains of simian immunodeficiency virus use CCR5 as a coreceptor for entry J. Virol. 71 1997 2705 2714
64. N. Michael Host genetic influences on HIV-1 pathogenesis Curr. Opin. Immunol. 11 1999 466 474
65. J.S. Cairns, and M.P. D'Souza Chemokines and HIV-1 second receptors: the connection Nat. Med. 4 1998 563 568
66. S.A. Limborska Analysis of CCr5delta32 geographic distribution and its correlation with some climatic and geographic factors Hum. Hered. 53 2002 49 54
67. I. Kalev High frequency of the HIV-1 protective CCR5 delta 32 deletion in native Estonians Eur. J. Edpidemiol. 16 2000 1107 1109
68. F. Struyf Prevalaence of CCR5 and CCR2 HIV-coreceptor gene polymorphisms in Belgium Hum. Hered. 50 2000 304 307
69. G. Lucotte, and G. Mercier Distribution of the CCR5 gene 32-bp deletion in Europe J. Acquir. Immune Defic. Syndr. 19 1998 174 177
70. G. Lucotte, and G. Mercier Delta 32 mutation frequencies of the CCR5 coreceptor in different French regions Comptes Rendus De L'Academie Des Science Serie Iii-Sciences De La Vie-Life Sciences 321 1998 409 413
71. R. Zamarachi Frequency of a mutated CCR-5 allele (delta32) among Italian healthy donors and individuals at risk of parenteral HIV infection AIDS Res. Hum. Retroviruses 15 1999 337 344
72. M. Magierowska Distribution of the CCR5 gene 32:bp deletion and sdf1-3′ a variant in healthy individuals from different populations Immunogenetics 48 1998 417 419
73. A. Voevodin, E. Samilchuk, and S. Dashti A survey for 32 nucleotide deletion in the CCR-5 chemokine receptor gene conferring resistance to human immunodeficiency virus type 1 in different ethnic groups and in chimpanzees J. Med. Virol. 55 1998 147 151
74. E. Elharti Frequency of the CCR5 delta 32 allele in the Moroccan population AIDS Res. Hum. Retroviruses 16 2000 87 89
75. R. Barbouche Contrasting frequencies of CCR5-delta32 and CCR2-64i allele in Tunisian populations J. Acquir. Immune Defic. Syndr. 26 2001 298 299