Mechanism of LIGHT/interferon-γ-induced cell death in HT-29 cells

Journal of Cellular Biochemistry

Volumn 93, Issue 6, 2004, Pages 1188-1202

  Chang, Ying Hsin ^a   Chao, Yee ^b   Hsieh, Shie Liang ^c   Lin, Wan Wan ^a  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

^c NATIONAL YANG MING UNIVERSITY   (Taiwan)

Author keywords

Caspase; IFN ; LIGHT; Mitochondrial; NF B; p38 MARK

Indexed keywords

AMITROLE; CASPASE 3; CASPASE 9; CATHEPSIN B; DNA FRAGMENT; ENDONUCLEASE; FAS ANTIGEN; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LACTATE DEHYDROGENASE; MITOGEN ACTIVATED PROTEIN KINASE P38; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; PROTEIN BAK; PROTEIN INHIBITOR; PROTEIN LIGHT; PROTEIN MCL 1; STAT1 PROTEIN; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; CELL SURFACE RECEPTOR; DECOY RECEPTOR 3; DNA BINDING PROTEIN; HERPESVIRUS ENTRY MEDIATOR LIGAND; LTBR PROTEIN, HUMAN; LYMPHOTOXIN BETA RECEPTOR; MEMBRANE PROTEIN; PROTEIN BCL 2; RECOMBINANT GAMMA INTERFERON; STAT1 PROTEIN, HUMAN; TNFRSF6B PROTEIN, HUMAN; TNFSF14 PROTEIN, HUMAN; TRANSACTIVATOR PROTEIN; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR;

ARTICLE; CELL DEATH; CELL SURVIVAL; DOWN REGULATION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; APOPTOSIS; CELL CYCLE; CELL MEMBRANE POTENTIAL; CELL STRAIN HT29; DRUG EFFECT; METABOLISM; MITOCHONDRION; SIGNAL TRANSDUCTION;

APOPTOSIS; CELL CYCLE; DNA-BINDING PROTEINS; HT29 CELLS; HUMANS; INTERFERON-GAMMA, RECOMBINANT; LYMPHOTOXIN BETA RECEPTOR; MEMBRANE GLYCOPROTEINS; MEMBRANE POTENTIALS; MEMBRANE PROTEINS; MITOCHONDRIA; NF-KAPPA B; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTO-ONCOGENE PROTEINS C-BCL-2; RECEPTORS, CELL SURFACE; RECEPTORS, TUMOR NECROSIS FACTOR; RECEPTORS, TUMOR NECROSIS FACTOR, MEMBER 6B; SIGNAL TRANSDUCTION; STAT1 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS; TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 14; TUMOR NECROSIS FACTOR-ALPHA;

EID: 21244458106     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.20282     Document Type: Article

References (58)

1. Adams JM, Cory S. 1998. The Bcl-2 protein family: Arbiters of cell survival. Science 281:1322-1326.
2. Ashkenazi A, Dixit VM. 1998. Death receptors: Signaling and modulation. Science 281:1305-1308.
3. Baker SJ, Reddy EP. 1998. Modulation of life and death by the TNF receptor superfamily. Oncogene 17:3261-3270.
4. Benchokroun Y, Couprie J, Larsen AK. 1995. Aurintricarboxylic acid, a putative inhibitor of apoptosis, is a potent inhibitor of DNA topoisomerase II in vitro and in Chinese hamster fibrosarcoma cells. Biochem Pharmacol 49:305-313.
5. Chang YH, Hsieh SL, Chen MC, Lin WW. 2002. Lymphotoxin beta receptor induces interleukin 8 gene expression via NF-kappaB and AP-1 activation. Exp Cell Res 278:166-174.
6. Chen MC, Hsu TL, Luh TY, Hsieh SL. 2000. Overexpression of bcl-2 enhances LIGHT- and interferon-gamma-mediated apoptosis in Hep3BT2 cells. J Biol Chem 275:38794-38801.
7. Chen CW, Chao Y, Chang YH, Hsu MJ, Lin WW. 2002. Inhibition of cytokine-induced JAK-STAT signaling pathways by an endonuclease inhibitor aurintricarboxylic acid. Br J Pharmacol 137:1011-1020.
8. Chen MC, Hwang MJ, Chou YC, Chen WH, Cheng G, Nakano H, Luh TY, Mai SC, Hsieh SL. 2003. The role of apoptosis signal-regulating kinase 1 in lymphotoxin-beta receptor-mediated cell death. J Biol Chem 278:16073-16081.
9. Chicheportiche Y, Bourdon PR, Xu H, Hsu YM, Scott H, Hession C, Garcia I, Browning JL. 1997. TWEAK, a new secreted ligand in the tumor necrosis factor family that weakly induces apoptosis. J Biol Chem 272:32401-32410.
10. Cuadrado A, Garcia-Fernandez LF, Gonzalez L, Suarez Y, Losada A, Alcaide V, Martinez T, Fernandez-Sousa JM, Sanchez-Puelles JM, Munoz A. 2003. Aplidin induces apoptosis in human cancer cells via glutathione depletion and sustained activation of the epidermal growth factor receptor, Src, JNK, and p38 MAPK. J Biol Chem 278:241-250.
11. Eby MT, Jasmin A, Kumar A, Sharma K, Chaudhary PM. 2000. TAJ, a novel member of the tumor necrosis factor receptor family, activates the c-Jun N-terminal kinase pathway and mediates caspase-independent cell death. J Biol Chem 275:15336-15342.
12. Fiers W, Beyaert R, Declercq W, Vandenabeele P. 1999. More than one way to die: Apoptosis, necrosis, and reactive oxygen damage. Oncogene 18:7719-7730.
13. Force WR, Cheung TC, Ware CF. 1997. Dominant negative mutants of TRAF3 reveal an important role for the coiled coil domains in cell death signaling by the lymphotoxin-beta receptor. J Biol Chem 272:30835-30840.
14. Garcia-Fernandez LF, Losada A, Alcaide V, Alvarez AM, Cuadrado A, Gonzalez L, Nakayama K, Nakayama KI, Fernandez-Sousa JM, Munoz A, Sanchez-Puelles JM. 2002. Aplidin induces the mitochondrial apoptotic pathway via oxidative stress-mediated JNK and p38 activation and protein kinase C delta. Oncogene 21:7533-7544.
15. Harrop JA, McDonnell PC, Brigham-Burke M, Lyn SD, Minton J, Tan KB, Dede K. 1998. Herpesvirus entry mediator ligand (HVEM-L), a novel ligand for HVEM/TR2, stimulates proliferation of T cells and inhibits HT29 cell growth. J Biol Chem 273:27548-27556.
16. Holler N, Zaru R, Micheau O, Thome M, Attinger A, Valitutti S, Bodmer JL, Schneider P, Seed B, Tschopp J. 2000. Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule. Nat Immunol 1:489-495.
17. Hong SJ, Dawson TM, Dawson VL. 2004. Nuclear and mitochondrial conversations in cell death: PARP-1 and AIF signaling. Trends Pharmacol Sci 25:259-264.
18. Hsu TL, Chang YC, Chen SJ, Liu YJ, Chiu AW, Chio CC, Chen L, Hsieh SL. 2002. Modulation of dendritic cell differentiation and maturation by decoy receptor 3. J Immunol 168:4846-4853.
19. Jeremias I, Kupatt C, Baumann B, Herr I, Wirth T, Debatin KM. 1998. Inhibition of nuclear factor kappa B activation attenuates apoptosis resistance in lymphoid cells. Blood 91:4624-4631.
20. Kano A, Haruyama T, Akaike T, Watanabe Y. 1999. IRF-1 is an essential mediator in IFN-gamma-induced cell cycle arrest and apoptosis in primary cultured hepatocytes. Biochem Biophys Res Commun 257:672-677.
21. Khwaja A, Tatton L. 1999. Resistance to the cytotoxic effects of tumor necrosis factor alpha can be overcome by inhibition of a FADD/caspase-dependent signaling pathway. J Biol Chem 274:36817-36823.
22. Kuo ML, Shen SC, Yang CH, Chuang SE, Cheng AL, Huang TS. 1998. Bcl-2 prevents topoisomerase II inhibitor GL331-induced apoptosis is mediated by down-regulation of poly(ADP-ribose)polymerase activity. Oncogene 17:2225-2234.
23. Li LY, Luo X, Wang X. 2001. Endonuclease G is an apoptotic DNase when released from mitochondria. Nature 412:95-99.
24. Lorenzo HK, Susin SA, Penninger J, Kroemer G. 1999. Apoptosis inducing factor (AIF): A phylogenetically old, caspase-independent effector of cell death. Cell Death Differ 6:516-524.
25. Matsumura H, Shimizu Y, Ohsawa Y, Kawahara A, Uchiyama Y, Nagata S. 2000. Necrotic death pathway in Fas receptor signaling. J Cell Biol 151:1247-1356.
26. Mauri DN, Ebner R, Montgomery RI, Kochel KD, Cheung TC, Yu GL, Ruben S, Murphy M, Eisenberg RJ, Cohen GH, Spear PG, Ware CF. 1998. LIGHT, a new member of the TNF superfamily, and lymphotoxin alpha are ligands for herpesvirus entry mediator. Immunity 8:21-30.
27. Maziere C, Conte MA, Maziere JC. 2001. Activation of the JAK/STAT pathway by ceramide in cultured human fibroblasts. FEBS Lett 507:163-168.
28. McCarthy NJ, Whyte MK, Gilbert CS, Evan GI. 1997. Inhibition of Ced-3/ICE-related proteases does not prevent cell death induced by oncogenes, DNA damage, or the Bcl-2 homologue Bak. J Cell Biol 136:215-227.
29. Nagata S. 1997. Apoptosis by death factor. Cell 88:355-365.
30. Nakano H, Oshima H, Chung W, Williams-Abbott L, Ware CF, Yagita H, Okumura K. 1996. TRAF5, an activator of NF-kappaB and putative signal transducer for the lymphotoxin-beta receptor. J Biol Chem 271:14661-14664.
31. Nakayama M, Ishidoh K, Kayagaki N, Kojima Y, Yamaguchi N, Nakano H, Kominami E, Okumura K, Yagita H. 2002. Multiple pathways of TWEAK-induced cell death. J Immunol 168:734-743.
32. Perkins ND. 2000. The Rel/NF-kappa B family: Friend and foe. Trends Biochem Sci 25:434-440.
33. Rooney IA, Butrovich KD, Glass AA, Borboroglu S, Benedict CA, Whitbeck JC, Cohen GH, Eisenberg RJ, Ware CF. 2000. The lymphotoxin-beta receptor is necessary and sufficient for LIGHT-mediated apoptosis of tumor cells. J Biol Chem 275:14307-14315.
34. Sah NK, Munshi A, Kurland JF, McDonnell TJ, Su B, Meyn RE. 2003. Translation inhibitors sensitize prostate cancer cells to apoptosis induced by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) by activating c-Jun N-terminal kinase. J Biol Chem 278:20593-20602.
35. Stephanou A, Scarabelli TM, Brar BK, Nakanishi Y, Matsumura M, Knight RA, Latchman DS. 2001. Induction of apoptosis and Fas receptor/Fas ligand expression by ischemia/reperfusion in cardiac myocytes requires serine 727 of the STAT-1 transcription factor but not tyrosine 701. J Biol Chem 276:28340-28347.
36. Sugarman BJ, Aggarwal BB, Hass PE, Figari IS, Palladino MA, Jr., Shepard HM. 1985. Recombinant human tumor necrosis factor-alpha: Effects on proliferation of normal and transformed cells in vitro. Science 230:943-945.
37. Suk K, Kim S, Kim YH, Kim KA, Chang I, Yagita H, Shong M, Lee MS. 2001. IFN-gamma/TNF-alpha synergism as the final effector in autoimmune diabetes: A key role for STAT1/IFN regulatory factor-1 pathway in pancreatic beta cell death. J Immunol 166:4481-4489.
38. Tamada K, Shimozaki K, Chapoval AI, Zhai Y, Su J, Chen SF, Hsieh SL, Nagata S, Ni J, Chen L. 2000a. LIGHT, a TNF-like molecule, costimulates T cell proliferation and is required for dendritic cell-mediated allogeneic T cell response. J Immunol 164:4105-4110.
39. Tamada K, Shimozaki K, Chapoval AI, Zhu G, Sica G, Flies D, Boone T, Hsu H, Fu YX, Nagata S, Ni J, Chen L. 2000b. Modulation of T-cell mediated immunity in tumor and graft-versus-host disease models through the LIGHT co-stimulatory pathway. Nat Med 6:283-289.
40. Tamura T, Ishihara M, Lamphier MS, Tanaka N, Oishi I, Aizawa S, Matsuyama T, Mak TW, Taki S, Taniguchi T. 1995. An IRF-1-dependent pathway of DNA damage-induced apoptosis in mitogen-activated T lymphocytes. Nature 376:596-599.
41. Tanaka N, Ishihara M, Kitagawa M, Harada H, Kimura T, Matsuyama T, Lamphier MS, Aizawa S, Mak TW, Taniguchi T. 1994. Cellular commitment to oncogene-induced transformation or apoptosis is dependent on the transcriptional factor IRF-1. Cell 77:829-839.
42. Thorburn A. 2004. Death receptor-induced cell killing. Cell Signal 16:139-144.
43. Tobiume K, Matsuzawa A, Takahashi T, Nishitoh H, Morita K, Takeda K, Minowa O, Miyazono K, Noda T, Ichijo H. 2001. ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis. EMBO 2:222-228.
44. Torriglia A, Perani P, Brossas JY, Altairac S, Zeggai S, Martin E, Treton J, Courtois Y, Counis MF. 2000. A caspase-independent cell clearance program: The LEI/L-DNase II pathway. Ann NY Acad Sci 926:192-203.
45. Walczak H, Krammer PH. 2000. The CD95 (APO-1/Fas) and the TRAIL (APO-2L) apoptosis systems. Exp Cell Res 256:58-66.
46. Wallach D, Varfolomeev EE, Malinin NL, Goltsev YV, Kovalenko AV, Boldin MP. 1999. Tumor necrosis factor receptor and Fas signaling mechanisms. Annu Rev Immunol 17:331-367.
47. Wang X. 2002. The expanding role of mitochondria in apoptosis. Genes Dev 15:2922-2933.
48. Wang Y, Wu TR, Cai S, Welte T, Chin YE. 2000. Stat1 as a component of tumor necrosis factor alpha receptor 1-TRADD signaling complex to inhibit NF-kappaB activation. Mol Cell Biol 20:4505-4512.
49. Wesemann DR, Benveniste EN. 2003. STAT-1 alpha and IFN-gamma as modulators of TNF-alpha signaling in macrophages: Regulation and functional implications of the TNF receptor 1:STAT-1 alpha complex. J Immunol 171:5313-5319.
50. Wiley SR, Schooley K, Smolak PJ, Din WS, Huang CP, Nicholl JK, Sutherland GR, Smith TD, Rauch C, Smith CA. 1995. Identification and characterization of a new memher of the TNF family that induces apoptosis. Immunity 3:673-682.
51. Wilson CA, Browning JL. 2002. Death of HT29 adenocarcinoma cells induced by TNF family receptor activation is caspase-independent and displays features of both apoptosis and necrosis. Cell Death Differ 12:1321-1333.
52. Wu MY, Hsu TL, Lin WW, Campbell RD, Hsieh SL. 1997. Serine/threonine kinase activity associated with the cytoplasmic domain of the lymphotoxin-beta receptor in HepG2 cells. J Biol Chem 272:17154-17159.
53. Wu MY, Wang PY, Han SH, Hsieh SL. 1999. The cytoplasmic domain of the lymphotoxin-beta receptor mediates cell death in HeLa cells. J Biol Chem 274:11868-11873.
54. Xiang J, Chao DT, Korsmeyer SJ. 1996. BAX-induced cell death may not require interleukin 1 beta-converting enzyme-like proteases. Proc Natl Acad Sci USA 93:14559-14563.
55. Xu X, Fu XY, Plate J, Chong AS. 1998. IFN-gamma induces cell growth inhibition by Fas-mediated apoptosis: Requirement of STAT1 protein for up-regulation of Fas and FasL expression. Cancer Res 58:2832-2837.
56. Yu KY, Kwon B, Ni J, Zhai Y, Ebner R, Kwon BS. 1999. A newly identified member of tumor necrosis factor receptor superfamily (TR6) suppresses LIGHT-mediated apoptosis. J Biol Chem 274:13733-13736.
57. Zhai Y, Guo R, Hsu TL, Yu GL, Ni J, Kwon BS, Jiang GW, Lu J, Tan J, Ugustus M, Carter K, Rojas L, Zhu F, Lincoln C, Endress G, Xing L, Wang S, Oh KO, Gentz R, Ruben S, Lippman ME, Hsieh SL, Yang D. 1998. LIGHT, a novel ligand for lymphotoxin beta receptor and TR2/HVEM induces apoptosis and suppresses in vivo tumor formation via gene transfer. J Clin Invest 102:1142-1151.
58. Zhang M, Guo R, Zhai Y, Yang D. 2003. LIGHT sensitizes IFNgamma-mediated apoptosis of MDA-MB-231 breast cancer cells leading to down-regulation of anti-apoptosis Bcl-2 family members. Cancer Lett 195:201-210.