Substantial regional variation in substitution rates in the human genome: Importance of GC content, gene density, and telomere-specific effects

Journal of Molecular Evolution

Volumn 60, Issue 6, 2005, Pages 748-763

  Arndt, Peter F ^a   Hwa, Terence ^b   Petrov, Dmitri A ^c  

^a MAX PLANCK INSTITUTE FOR MOLECULAR GENETICS   (Germany)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c STANFORD UNIVERSITY   (United States)

Author keywords

Genome evolution; Genomic isochores; Nucleotide substitution; Short interspersed elements

Indexed keywords

ADENINE NUCLEOTIDE; GUANOSINE; PYRIMIDINE NUCLEOTIDE;

AMINO ACID SUBSTITUTION; ARTICLE; COMPARATIVE GENE MAPPING; CYTOGENETICS; DENSITY; EXON; GENE CLUSTER; GENE CONVERSION; GENE MUTATION; GENE STRUCTURE; GENETIC VARIABILITY; GENOME ANALYSIS; HUMAN; HUMAN GENOME; ISOCHORE; MOLECULAR EVOLUTION; MUTATION RATE; PREDICTION; SHORT INTERSPERSED REPEAT; TELOMERE; CHROMOSOME; DNA BASE COMPOSITION; GC RICH SEQUENCE; GENOME; MUTATION; STATISTICAL MODEL; THEORETICAL MODEL; ULTRASTRUCTURE;

MAMMALIA;

BASE COMPOSITION; CHROMOSOMES; EVOLUTION, MOLECULAR; EXONS; GC RICH SEQUENCE; GENOME; GENOME, HUMAN; HUMANS; MODELS, STATISTICAL; MODELS, THEORETICAL; MUTATION; SHORT INTERSPERSED NUCLEOTIDE ELEMENTS; TELOMERE; VARIATION (GENETICS);

EID: 21244454414     PISSN: 00222844     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00239-004-0222-5     Document Type: Article

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