Effects of Y132H and F145L substitutions on the activity, azole resistance and spectral properties of Candida albicans sterol 14-demethylase P450 (CYP51): A live example showing the selection of altered P450 through interaction with environmental compounds

Journal of Biochemistry

Volumn 137, Issue 5, 2005, Pages 625-632

  Kudo, Makiko ^a   Ohi, Miwa ^a   Aoyama, Yuri ^b   Nitahara, Yuko ^b   Chung, Sung Kee ^c   Yoshida, Yuzo ^a  

^a MUKOGAWA WOMEN'S UNIVERSITY   (Japan)

^b SOKA UNIVERSITY   (Japan)

^c Pohang University of Science and Technology (POSTECH)   (South Korea)

Author keywords

Azole antifungal agent; Azole resistance; Biodiversity; CYP51; CYP51 variant; Cytochrome P450; Fungus; Mutation; Site directed mutagenesis; Sterol 14 demethylase

Indexed keywords

ANTIFUNGAL AGENT; CYTOCHROME P450; FLUCONAZOLE; PYRROLE; STEROL 14ALPHA DEMETHYLASE;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BIODIVERSITY; CANDIDA ALBICANS; CATALYSIS; CELL INTERACTION; CELL SELECTION; ENZYME ACTIVITY; ENZYME PURIFICATION; ENZYME SPECIFICITY; GENE DUPLICATION; GENETIC ANALYSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PHYLOGENY; PROTEIN PROTEIN INTERACTION; SITE DIRECTED MUTAGENESIS; SPECTROSCOPY;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANTIFUNGAL AGENTS; AZOLES; CANDIDA ALBICANS; CYTOCHROME P-450 ENZYME SYSTEM; DITHIONITE; DRUG RESISTANCE, MICROBIAL; ESCHERICHIA COLI; FLUCONAZOLE; FUNGAL PROTEINS; HEME; OXIDOREDUCTASES; SPECTRUM ANALYSIS;

CANDIDA ALBICANS; FUNGI;

EID: 21044452931     PISSN: 0021924X     EISSN: None     Source Type: Journal    
DOI: 10.1093/jb/mvi073     Document Type: Article

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