LRIG1 restricts growth factor signaling by enhancing receptor ubiquitylation and degradation

EMBO Journal

Volumn 23, Issue 16, 2004, Pages 3270-3281

  Gur, Gal ^a   Rubin, Chanan ^a   Katz, Menachem ^a   Amit, Ido ^a   Citri, Ami ^a   Nilsson, Jonas ^b   Amariglio, Ninette ^c   Henriksson, Roger ^b   Rechavi, Gideon ^c   Hedman, Håkan ^b   Wides, Ron ^d   Yarden, Yosef ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^b UMEÅ UNIVERSITY   (Sweden)

^c TEL AVIV UNIVERSITY   (Israel)

^d BAR ILAN UNIVERSITY   (Israel)

Author keywords

Cancer; Growth factor; Signal transduction; Tyrosine kinase; Ubiquitin ligase

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; GROWTH FACTOR RECEPTOR; MEMBRANE PROTEIN; PROTEIN; PROTEIN LRIG1; PROTEIN TYROSINE KINASE; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG;

ARTICLE; CELL FATE; CELL STIMULATION; DESENSITIZATION; HYPERPLASIA; NEGATIVE FEEDBACK; OOCYTE DEVELOPMENT; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; UBIQUITINATION;

BINDING SITES; CELL LINE; EPIDERMAL GROWTH FACTOR; EVOLUTION, MOLECULAR; HUMANS; LIGANDS; MEMBRANE GLYCOPROTEINS; ONCOGENE PROTEINS V-ERBB; PHOSPHOTYROSINE; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-CBL; RECEPTOR, EPIDERMAL GROWTH FACTOR; RNA, MESSENGER; SIGNAL TRANSDUCTION; SUBSTRATE SPECIFICITY; UBIQUITIN; UBIQUITIN-PROTEIN LIGASES;

MAMMALIA; RODENTIA;

EID: 20844462896     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.emboj.7600342     Document Type: Article

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