Mesangial Iga1 in IgA nephropathy exhibits aberrant O-glycosylation: Observations in three patients

Kidney International

Volumn 60, Issue 3, 2001, Pages 969-973

  Allen, Alice C ^a,b   Bailey, Elaine M ^a,b   Brenchley, Paul E C ^a,b   Buck, Katharine S ^a,b   Barratt, Jonathan ^a,b   Feehally, John ^a,b  

^a LEICESTER GENERAL HOSPITAL   (United Kingdom)

^b MANCHESTER ROYAL INFIRMARY   (United Kingdom)

Author keywords

Glomerulonephritis; Helix aspersa lectin; Lectin binding; Sialylation; Vicia villosa lectin

Indexed keywords

IMMUNOGLOBULIN A1;

ADULT; ARTICLE; AUTOPSY; CLINICAL ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; DISEASE COURSE; ENZYME LINKED IMMUNOSORBENT ASSAY; GLOMERULUS; GLYCOSYLATION; HUMAN; HUMAN TISSUE; IMMUNOGLOBULIN A NEPHROPATHY; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOHISTOCHEMISTRY; KIDNEY; KIDNEY BIOPSY; LECTIN BINDING; MALE; MESANGIUM CELL; NEPHRECTOMY; PRIORITY JOURNAL;

EID: 0035723058     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1755.2001.060003969.x     Document Type: Article

References (16)

1. Defective galactosylation and clearance of IgA1 molecules as a possible etiopathogenic factor in IgA nephropathy
2. Structural features of IgA molecules which contribute to IgA nephropathy
3. The structure and function of human IgA
4. O-linked oligosaccharide from human serum immunoglobulin A 1
5. Galactosylation of N- and O-linked carbohydrate moieties of IgA1 and IgG in IgA nephropathy
6. Galactose-deficient IgA 1 in sera of IgA nephropathy patients is present in complexes with IgG
7. Association of asialo-galactosylβ1-3 N-acetyl galactosamine on the hinge with a conformational instability of jacalin reactive immunoglobulin A1 in immunoglobulin A nephropathy
8. Analyses of IgA1 hinge glycopeptides in IgA nephropathy by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry
9. Analysis of IgA1 O-glycans in IgA nephropathy by fluorophore assisted carbohydrate electrophoresis
10. Charge and size of mesangial IgA in IgA nephropathy
11. Abnormal IgA glycosylation in Henoch-Schönlein purpura restricted to patients with clinical nephritis
12. Evidence for involvement of IgA1 hinge glycopeptide in the IgA1-IgA 1 interaction in IgA nephropathy
13. Circulating immune complexes in IgA nephropathy consist of IgA1 with galactose-deficient hinge region and antiglycan antibodies
14. Protective role of IgA1 glycans against IgA1 self-aggregation and adhesion to extracellular matrix proteins
15. Serum IgA and macromolecular IgA reacting with mesangial matrix components
16. Underglycosylation of IgA 1 hinge plays a certain role for its glomerular deposition in IgA nephropathy