Complexes of IgA with FcαRI/CD89 are not specific for primary IgA nephropathy

Kidney International

Volumn 63, Issue 2, 2003, Pages 514-521

  Van Der Boog, Paul J M ^a   De Fijter, Johan W ^a   Van Kooten, Cees ^a   Van Der Holst, Rutger ^a   Van Seggelen, Anneke ^a   Van Es, Leendert A ^a   Daha, Mohamed R ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

CD89; Cytokines; Glomerulonephritis; Glycosylation; IgA nephropathy; Macromolecular IgA; Mesangial deposits

Indexed keywords

ANTIGEN; CD89 ANTIGEN; FC RECEPTOR; IMMUNOGLOBULIN A; MONOCLONAL ANTIBODY; POLYCLONAL ANTIBODY; UNCLASSIFIED DRUG; FC(ALPHA) RECEPTOR; LEUKOCYTE ANTIGEN;

ADULT; AGED; ANALYTIC METHOD; ANTIBODY DETECTION; ANTIGEN DETECTION; ARTICLE; BLOOD LEVEL; CLINICAL ARTICLE; COMPARATIVE STUDY; COMPLEX FORMATION; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE ASSOCIATION; DISEASE COURSE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FRACTIONATION; HUMAN; IMMUNOGLOBULIN A NEPHROPATHY; MALE; MOLECULAR WEIGHT; NEPHRITIS; PARAMETER; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN PURIFICATION; QUANTITATIVE ANALYSIS; BLOOD; CASE CONTROL STUDY; CHEMISTRY; ISOLATION AND PURIFICATION; METHODOLOGY; MIDDLE AGED;

ADULT; ANTIGENS, CD; CASE-CONTROL STUDIES; CHEMICAL FRACTIONATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; GLOMERULONEPHRITIS, IGA; HUMANS; IMMUNOGLOBULIN A; MALE; MIDDLE AGED; MOLECULAR WEIGHT; RECEPTORS, FC;

EID: 0037246047     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1755.2003.00756.x     Document Type: Article

References (32)

1. D'AMICO G: The commonest glomerulonephritis in the world: IgA nephropathy. Q J Med 64:709-727, 1987
2. SCHENA FP: A retrospective analysis of the natural history of primary IgA nephropathy worldwide. Am J Med 89:209-215, 1990
3. CONLEY ME, COOPER MD, MICHAEL AF: Selective deposition of immunoglobulin A1 in immunoglobulin A nephropathy, anaphylactoid purpura nephritis, and systemic lupus erythematosus. J Clin Invest 66:1432-1436, 1980
4. VALENTIJN RM, RADL J, HAAIJMAN JJ, et al: Circulating and mesangial secretory component-binding IgA-1 in primary IgA nephropathy. Kidney Int 26:760-766, 1984
5. DE FIJTER JW, EIJGENRAAM JW, BRAAM CA, et al: Deficient IgA1 immune response to nasal cholera toxin subunit B in primary IgA nephropathy. Kidney Int 50:952-961, 1996
6. ALLEN AC, HARPER SJ, FEEHALLY J: Galactosylation of N- and O-linked carbohydrate moieties of IgA1 and IgG in IgA nephropathy. Clin Exp Immunol 100:470-474, 1995
7. ALLEN AC, BAILEY EM, BRENCHLEY PE, et al: Mesangial IgA1 in IgA nephropathy exhibits aberrant O-glycosylation: Observations in three patients. Kidney Int 60:969-973, 2001
8. HIKI Y, ODANI H, TAKAHASHI M, et al: Mass spectrometry proves under-O-glycosylation of glomerular IgA1 in IgA nephropathy. Kidney Int 59:1077-1085, 2001
9. TOMANA M, NOVAK J, JULIAN BA, et al: Circulating immune complexes in IgA nephropathy consist of IgA1 with galactose-deficient hinge region and antiglycan antibodies. J Clin Invest 104:73-81, 1999
10. RIFAI A, FADDEN K, MORRISON SL, CHINTALACHARUVU KR: The N-glycans determine the differential blood clearance and hepatic uptake of human immunoglobulin (Ig)A1 and IgA2 isotypes. J Exp Med 191:2171-2182, 2000
11. MALISZEWSKI CR, MARCH CJ, SCHOENBORN MA, et al: Expression cloning of a human Fc receptor for IgA. J Exp Med 172:1665-1672, 1990
12. MOURA IC, CENTELLES MN, ARCOS-FAJARDO M, et al: Identification of the transferrin receptor as a novel immunoglobulin (Ig)A1 receptor and its enhanced expression on mesangial cells in IgA ne-phropathy. J Exp Med 194:417-425, 2001
13. MOSTOV KE: Transepithelial transport of immunoglobulins. Annu Rev Immunol 12:63-84, 1994
14. SHIBUYA A, SAKAMOTO N, SHIMIZU Y, et al: Fc alpha/mu receptor mediates endocytosis of IgM-coated microbes. Nat Immunol 1:441-446, 2000
15. STOCKERT RJ, KRESSNER MS, COLLINS JC, et al: IgA interaction with the asialoglycoprotein receptor. Proc Natl Acad Sci USA 79:6229-6231, 1982
16. BARRATT J, GREER MR, PAWLUCZYK IZ, et al: Identification of a novel Fcalpha receptor expressed by human mesangial cells. Kidney Int 57:1936-1948, 2000
17. KITAMURA T, GAROFALO RP, KAMIJO A, et al: Human intestinal epithelial cells express a novel receptor for IgA. J Immunol 164:5029-5034, 2000
18. MILLET I, BRIERE F, VINCENT C, et al: Spontaneous expression of a low affinity Fc receptor for IgA (Fc alpha R) on human B cell lines. Clin Exp Immunol 76:268-273, 1989
19. WESTERHUIS R,VAN ZANDBERGEN G, VERHAGEN NA, et al: Human mesangial cells in culture and in kidney sections fail to express Fc alpha receptor (CD89). J Am Soc Nephrol 10:770-778, 1999
20. ROCCATELLO D, PICCIOTTO G, TORCHIO M: Removal systems of immunoglobulin A and immunoglobulin A containing complexes in IgA nephropathy and cirrhosis patients. The role of asialoglycoprotein receptors. Lab Invest 69:714-723, 1993
21. GROSSETETE B, LAUNAY P, LEHUEN A, et al: Down-regulation of Fc alpha receptors on blood cells of IgA nephropathy patients: Evidence for a negative regulatory role of serum IgA. Kidney Int 53:1321-1335, 1998
22. RETERINK TJ, VAN ZANDBERGEN G, VAN EGMOND M, et al: Size-dependent effect of IgA on the IgA Fc receptor (CD89). Eur J Immunol 27:2219-2224, 1997
23. VAN ZANDBERGEN G,VAN KOOTEN C, MOHAMAD NK, et al: Reduced binding of immunoglobulin A (IgA) from patients with primary IgA nephropathy to the myeloid IgA Fc-receptor, CD89. Nephrol Dial Transplant 13:3058-3064, 1998
24. DIVEN SC, CAFLISCH CR, HAMMOND DK, et al: IgA induced activation of human mesangial cells: Independent of FcalphaR1 (CD89). Kidney Int 54:837-847, 1998
25. GOMEZ-GUERRERO C, GONZALEZ E, EGIDO J: Evidence for a specific IgA receptor in rat and human mesangial cells. J Immunol 151:7172-7181, 1993
26. LAI KN, TO WY, LI PK, LEUNG JC: Increased binding of polymeric lambda-IgA to cultured human mesangial cells in IgA nephropathy. Kidney Int 49:839-845, 1996
27. LEUNG JC, TSANG AW, CHAN DT, LAI KN: Absence of CD89, polymeric immunoglobulin receptor, and asialoglycoprotein receptor on human mesangial cells. J Am Soc Nephrol 11:241-249, 2000
28. LAUNAY P, GROSSETETE B, ARCOS-FAJARDO M, et al: Fcalpha receptor (CD89) mediates the development of immunoglobulin A (IgA) nephropathy (Berger's disease). Evidence for pathogenic soluble receptor-Iga complexes in patients and CD89 transgenic mice. J Exp Med 191:1999-2009, 2000
29. VAN ZANDBERGEN G, WESTERHUIS R, MOHAMAD NK, et al: Cross-linking of the human Fc receptor for IgA (FcalphaRI/CD89) triggers FcR gamma-chain-dependent shedding of soluble CD89. J Immunol 163:5806-5812, 1999
30. VAN DER BOOG PJ, VAN ZANDBERGEN G, DE FIJTER JW, et al: Fc-alphaRI/CD89 circulates in human serum covalently linked to IgA in a polymeric state. J Immunol 168:1252-1258, 2002
31. MORTON HC,VAN ZANDBERGEN G,VAN KOOTEN C, et al: Immuno-globulin-binding sites of human FcalphaRI (CD89) and bovine Fcgamma2R are located in their membrane-distal extracellular domains. J Exp Med 189:1715-1722, 1999
32. DE FIJTER JW, VAN DEN WALL BAKE AW, BRAAM CA, et al: Immunoglobulin A subclass measurement in serum and saliva: Sensitivity of detection of dimeric IgA2 in ELISA depends on the antibody used. J Immunol Methods 187:221-232, 1995