Leucocyte β1,3 galactosyltransferase activity in IgA nephropathy

Nephrology Dialysis Transplantation

Volumn 12, Issue 4, 1997, Pages 701-706

  Allen, A C ^a   Topham, P S ^a   Harper, S J ^a   Feehally, J ^a  

^a LEICESTER GENERAL HOSPITAL   (United Kingdom)

Author keywords

1,3 galactosyltransferase; IgA glycosylation; IgA nephropathy; Vicia villosa lectin

Indexed keywords

GALACTOSYLTRANSFERASE; GLYCAN; IMMUNOGLOBULIN A1; LECTIN;

ADULT; ARTICLE; B LYMPHOCYTE; CARBOHYDRATE METABOLISM; CELL LYSATE; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; HUMAN; HUMAN CELL; IMMUNOGLOBULIN A NEPHROPATHY; MALE; MONOCYTE; PATHOGENESIS; PRIORITY JOURNAL; T LYMPHOCYTE;

ADULT; B-LYMPHOCYTES; CARBOHYDRATE CONFORMATION; CASE-CONTROL STUDIES; FEMALE; GALACTOSYLTRANSFERASES; GLOMERULONEPHRITIS, IGA; GLYCOSYLATION; HUMANS; IMMUNOGLOBULIN A; LEUKOCYTES; MALE; MIDDLE AGED; MOLECULAR STRUCTURE; MONOCYTES; T-LYMPHOCYTES;

EID: 0030894229     PISSN: 09310509     EISSN: None     Source Type: Journal    
DOI: 10.1093/ndt/12.4.701     Document Type: Article

References (30)

1. d'Amico G. The commonest glomerulonephritis in the world: IgA nephropathy. Q J Med 1987; 245: 709-727
2. Valentijn RM, Radl J, Haajiman JJ et al. Circulating and mesangial secretory component binding IgA1 in primary IgA nephropathy. Kidney Int 1984; 26: 760-766
3. Feehally J. Immune mechanisms in glomerular IgA deposition. Nephrol Dial Transplant 1988; 3: 361-378
4. Andre PM, le Pogamp P, Chevet D. Impairment of jacalin binding to serum IgA in IgA nephropathy. J Clin Lab Anal 1990; 4: 115-119
5. Mestecky J, Tomana M, Crowley-Nowick PA et al. Defective galactosylation and clearance of IgA1 molecules as a possible etiopathogenic factor in IgA nephropathy. Contrib Nephrol 1993; 104: 172-182
6. Hiki Y, Horii A, Iwase H et al. O-linked oligosaccharide on IgA1 hinge region in IgA nephropathy. Fundamental study for precise structure and possible role. Contrib Nephrol 1995; 111: 73-84
7. Allen AC, Harper SJ, Feehally J. Galactosylation of N- and O-linked carbohydrate moieties of IgA1 and IgG in IgA nephropathy. Clin Exp Immunol 1995; 100: 470-474
8. Kerr MA. The structure and function of human IgA. Biochem J 1990; 271: 285-296
9. Moldoveanu Z, Moro I, Radl J et al. Site of catabolism of autologous and heterologous IgA in non-human primates. Scand J Immunol 1990; 32: 577-583
10. Burton DR, Woof JM. Human antibody effector function. Adv Immunol 1992; 51: 1-84
11. Jefferis R. The glycosylation of antibody molecules: functional significance. Glycoconjugate J 1993; 10: 358-361
12. Baenziger J, Kornfeld S. Structure of the carbohydrate units of IgA1 immunoglobulin. II. Structure of the O-glycosidically linked oligosaccharide units. J Biol Chem 1974; 249: 7270-7281
13. Field MC, Dwek RA, Edge CJ, Rademacher TW. O-linked oligosaccharide from human serum immunoglobulin A1. Biochem Soc Trans 1989; 17: 1034-1035
14. Baenziger JU. Protein-specific glycosyltransferases: how and why they do it! FASEB J 1994; 8: 1019-125.
15. Tollefsen SE, Kornfeld R. Isolation and characterization of lectins from Vicia villosa. Two distinct carbohydrate binding activities are present in seed extracts. J Biol Chem 1983; 258: 5165-5171
16. Osawa T, Tsuji T. Fractionation and structural assessment of oligosaccharides and glycopeptides by use of immobilized lectins. Ann Rev Biochem 1987; 56: 21-42
17. Tomino Y, Ohmuro H, Takahashi Y et al. Binding capacity of serum IgA to jacalin inpatients with IgA nephropathy using jacalin-coated microplates. Nephron 1995; 70: 329-333
18. Hiki Y, Iwase H, Saitoh M et al. Reactivity of glomerular and serum IgA1 to jacalin in IgA nephropathy. Nephron 1996; 72: 429-435
19. Parekh RB, Dwek RA, Sutton BJ et al. Association of rheumatoid arthritis and primary osteoarthritis with changes in the glycosylation pattern of total serum IgG. Nature 1985; 316: 452-457
20. Axford JS, Sumar N, Alavi A et al. Changes in normal glycosylation mechanisms in autoimmune rheumatic disease. J Clin Invest 1992; 89: 1021-1031
21. Lee LT, Frank S, de Jongh DS, Howe C. Immunochemical studies on Tn erythrocyte glycoprotein. Blood 1981; 58: 1228-1231
22. Blumenfeld OO, Lalezari P, Khorshidi M, Puglia K, Fukuda M. O-linked oligosaccharides of glycophorins A and B in erythrocytes of two inidividuals with the Tn polyagglutinability syndrome. Blood 1992; 80: 2388-2395
23. Cartron J-P, Andreu G, Cartron J et al. Demonstration of T-transferase deficiency in Tn-polyagglutinable blood samples. Eur J Biochem 1978; 92: 111-119
24. Cartron J-P, Nurden AT. Galactosyltransferase and membrane glycoprotein abnormality in human platelets from Tn-syndrome donors. Nature 1979; 282: 621-623
25. Thurnher M, Rusconi S, Berger EG. Persistent repression of a functional allele can be responsible for galactosyltransferase deiciency in the Tn syndrome. J Clin Invest 1993; 91; 2103-2110
26. Gomez-Guerrero C, Lopez-Armada MJ, Gonzalez E, Egido J. Soluble IgA and IgG aggregates are catabolized by cultured rat mesangial cells and induce production of TNF- and IL-6, and proliferation. J Immunol 1993; 153: 5247-5255
27. Allen AC, Greer MR, Combe C et al. Binding of human IgA to human leucocytes and mesangial cells (abstract). J Am Soc Nephrol 1994; 5: 739
28. Egido J, Sancho J, Rivera F, Hernando L. The role of IgA and IgG immune complexes in IgA nephropathy. Nephron 1984; 36: 52-59
29. van Es LA, van den Wall Bake AWL, Valentijn RM, Daha MR. Composition of IgA-containing circulating immune complexes in IgA nephropathy. Am J Kidney Dis 1988; 12: 397-401
30. Layward L, Allen AC, Hattersley JM, Harper SJ, Feehally J. Low affinity antibody restricted to the IgA isotype in IgA nephropathy. Clin Exp Immunol 1994; 95: 35-41