메뉴 건너뛰기




Volumn 3, Issue 11, 2005, Pages 2150-2154

Synthesis and biological evaluation of novel fumagillin and ovalicin analogues

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; ENZYME INHIBITION; ONCOLOGY; REACTION KINETICS; REDUCTION; SYNTHESIS (CHEMICAL); TOXIC MATERIALS; TUMORS;

EID: 20844459615     PISSN: 14770520     EISSN: None     Source Type: Journal    
DOI: 10.1039/b503163j     Document Type: Article
Times cited : (24)

References (53)
  • 5
    • 0000791295 scopus 로고    scopus 로고
    • ed. A. S. Fauci, E. Braunwald, K. J. Isselbacher, J. D. Wilson, J. B. Martin, D. L. Kasper, S. L. Hauser and D. L. Longo, McGraw Hill, New York
    • D. W. Foster, in Harrison's Principles of Internal Medicine, 14th ed., ed. A. S. Fauci, E. Braunwald, K. J. Isselbacher, J. D. Wilson, J. B. Martin, D. L. Kasper, S. L. Hauser and D. L. Longo, McGraw Hill, New York, 1998, p. 2075.
    • (1998) Harrison's Principles of Internal Medicine, 14th Ed. , pp. 2075
    • Foster, D.W.1
  • 43
    • 20844439960 scopus 로고    scopus 로고
    • note
    • 6-nBuLi.
  • 46
    • 2742601468 scopus 로고    scopus 로고
    • Whereas employing methyl lithium in lieu of Grignard reagents yields a mixture of both diastereomers. We assume that the complexation of the aldehyde, apart from steric factors and its spatial fixation is crucial for the excellent stereoselectivity. The configuration of the newly generated stereocenter was assigned by transformation of compound 10 into a dioxydecaline derivative and comparison of the chemical shifts to literature data; see: K. Pihlaja, J. Mattinen and J. Czombos, J. Prakt. Chem./ Chem.-Ztg.. 1997, 339, 77-78.
    • (1997) J. Prakt. Chem./ Chem.-ztg.. , vol.339 , pp. 77-78
    • Pihlaja, K.1    Mattinen, J.2    Czombos, J.3
  • 51
    • 20844442543 scopus 로고    scopus 로고
    • note
    • Depending on reaction time, conditions and number of equivalents of ylide, the major side products were either the a,β-unsaturated ketone or the cyclopropylated consecutive product.
  • 52
    • 20844443552 scopus 로고    scopus 로고
    • note
    • The relative configuration of both epoxides was assigned by NOE.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.